Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935

European Journal of Pharmacology

Volumn 300, Issue 1-2, 1996, Pages 141-145

  Pauwels, Petrus J ^a   Colpaert, Francis C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

5 HT1B receptor antagonist; 5 HT1B receptor, human, cloned; 5 HT1D receptor antagonist; 5 HT1D receptor, human, cloned; cAMP formation; GR 127,935; Ketanserin; Transfected rat C6 glial cell line

Indexed keywords

5 CARBAMOYLTRYPTAMINE; CYCLIC AMP; FORSKOLIN; KETANSERIN; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NARATRIPTAN; RADIOLIGAND; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG SELECTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; GLIA CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; CELL LINE; CYCLIC AMP; DRUG INTERACTIONS; FORSKOLIN; HUMANS; KETANSERIN; NEUROGLIA; OXADIAZOLES; PIPERAZINES; RATS; SEROTONIN ANTAGONISTS; TRANSFECTION;

EID: 0029874729     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00011-8     Document Type: Article

References (15)

1. 1-like receptor in rabbit renal artery, Eur. J. Pharmacol. 231, 469.
2. 1D antagonists, J. Med. Chem. 37, 2253.
3. 1Dβ receptor subtype in human and bovine cerebral arteries, Mol. Pharmacol. 44, 242.
4. Kaumann, A.J., A.A. Parsons and A.M. Brown, 1993, Human arterial constrictor serotonin receptors, Cardiovasc. Res. 27, 2094.
5. 2 receptors in serotonin-induced contraction of human isolated coronary arteries, Circulation 90, 1141.
6. Martin, G.R. and S.J. Maclennan, 1990, Analysis of the 5-HT receptor in rabbit saphenous vein exemplifies the problems of using exclusion criteria for receptor classification, Naunyn-Schmied. Arch. Pharmacol. 342, 111.
7. 1Dα receptor sites, Neuropharmacology 34, 235.
8. 1B receptors, Eur. J. Pharmacol. Mol. Pharmacol. 290, 95.
9. 1B receptors, Naunyn-Schmied. Arch. Pharmacol. 351, 1.
10. 1D receptors, Biol. Signals 3, 217.
11. Razzaque, Z., J. Longmore and R.G. Hill, 1995, Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein, Eur. J. Pharmacol. 283, 199.
12. 1Dα serotonin receptor gene expression in trigeminal ganglia: implication for antimigraine drug development, Proc. Natl. Acad. Sci. USA 91, 3666.
13. 1-like receptors mediate 5-hydroxytryptamine-induced contraction of guinea-pig isolated iliac artery, Br. J. Pharmacol. 102, 386.
14. Tilford, N.S. and G.S. Baxter, 1994, The actions of ketanserin and ritanserin on contractile responses to sumatriptan in rabbit basilar artery, Br. J. Pharmacol. 112, 478P.
15. 1Dβ, Proc. Natl. Acad. Sci. USA 89, 3630.