Operational characteristics of the 5-HT1-like receptors mediating external carotid vasaconstriction in vagosympathectomized dogs. Close resemblance to the 5-HT(1D) receptor subtype

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 354, Issue 5, 1996, Pages 550-556

  Villalón, Carlos M ^a   Sánchez López, Araceli ^a   Centurión, David ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

5 HT(1D) receptors; 5 Hydroxytryptamine; Carotid blood flow; GR127935; Sumatriptan; Vasoconstriction

Indexed keywords

METHYSERGIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NORADRENALIN; OXYMETAZOLINE; RITANSERIN; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 1D RECEPTOR; SUMATRIPTAN;

ANIMAL EXPERIMENT; ARTICLE; CAROTID ARTERY FLOW; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; NONHUMAN; VASOCONSTRICTION;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; CAROTID ARTERY, COMMON; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; MALE; METHYSERGIDE; OXADIAZOLES; PIPERAZINES; RECEPTORS, SEROTONIN; REGIONAL BLOOD FLOW; RITANSERIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUMATRIPTAN; VASOCONSTRICTION;

EID: 0029857651     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. 1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci USA 90: 408-412
2. 1F receptor to multiple signal transduction pathways. Naunyn-Schmiedeberg's Arch Pharmacol 348: 566-575
3. 1D receptor antagonist. Br J Pharmacol 118: 85-92
4. 1D receptors of 5-hydroxytryptamine-induced contractions of rabbit middle and posterior cerebral arteries. Br J Pharmacol 112: 939-945
5. 1D receptors involved? Naunyn-Schmiedeberg's Arch Pharmacol 345: 509-515
6. 1Dβ T355N mutant receptors may involve formation of two hydrogen bonds to asparagine. Mol Pharmacol 49: 198-206
7. 1D binding sites. Br J Pharmacol 102: 227-233
8. 1Dβ receptor subtype in human and bovine cerebral arteries. Mol Pharmacol 44: 242-246
9. 1D receptor subtypes. Trends Pharmacol Sci 17: 103-105
10. 3H]5-HT binding site subtype in bovine brain membranes. J Neurosci 7: 894-903
11. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46: 157-203
12. Kaumann AJ, Parsons AA, Brown AM (1993) Human arterial constrictor serotonin receptors. Cardiovasc Res 27: 2094-2103
13. 1Dβ receptors. Circulation 90: 1141-1153
14. Martin GR (1994) Vascular receptors for 5-hydroxytryptamine: distribution, function and classification. Pharmacol Ther 62: 283-324
15. Müller-Schweinitzer E (1986) Serotonergic receptors in brain vessels. In: Owman C, Hardebo JE (eds) Neural regulation of brain circulation. Elsevier, Amsterdam, pp 219-234
16. Saxena PR (1972) The effects of antimigraine drugs on the vascular responses by 5-hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: Possible pharmacological implications to their antimigraine action. Headache 12: 44-54
17. Saxena PR (1974) Selective vasoconstriction in carotid vascular bed by methysergide: possible relevance to its antimigraine effect. Eur J Pharmacol 27: 99-105
18. Saxena PR, Villalón CM (1990) Cardiovascular effects of serotonin agonists and antagonists. J Cardiovasc Pharmacol 15 [Suppl 7]: S17-S34
19. Saxena PR, Villalón CM (1991) 5-Hydroxytryptamine, a chameleon in the heart. Trends Pharmacol Sci 12: 223-227
20. 1D receptors. Naunyn-Schmiedeberg's Arch Pharmacol: 340: 135-138
21. 1D receptor subtype. J Pharmacol Exp Ther 252: 387-395
22. 1D receptors. Eur J Pharmacol 196: 213-216
23. 1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra. Naunyn-Schmiedeberg's Arch Pharmacol 337: 602-608
24. 1D receptor antagonist. Behav Brain Res, 73: 157-161
25. Steel RGD, Torrie JH (1980) Principles and procedures of statistics, a biomedical approach, 2nd edn. McGraw-Hill Kogakusha, Tokyo
26. 1D binding sites in porcine brain can be sub-divided by GR43175. Br J Pharmacol 98: 29-31
27. Terrón JA, Hong E, López-Muñoz FJ, Villalón CM (1994) Inhibition of serotonin-induced increase in canine external carotid blood flow by drugs that decrease the sympathetic outflow. J Auton Pharmacol 14: 165-175
28. 1-adrenoceptors in the reduction of external carotid blood flow induced by buspirone and ipsapirone in the dog. Life Sci 58: 63-73
29. 1D subtype. Br J Pharmacol. 113: 13-20
30. Villalón CM, Terrón JA (1994b) Characterization of the mechanisms involved in the effects of catecholamines on the canine external carotid blood flow. Can J Physiol Pharmacol 72 [Suppl 1]: 165
31. 1-like receptors in the increase in external carotid blood flow induced by 5-HT in the dog. Eur J Pharmacol, 240: 9-20
32. 1-like receptors mediating the increase in external carotid blood flow in the dog. Drug Develop Res 29: 271-281
33. Villalón CM, Ramírez-San Juan E, Castillo C, Castillo E, Lopez-Muñoz FJ, Terrón JA (1995a) Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5-HT in vagosympathectomized dogs. Br J Pharmacol 116: 2778-2784
34. Villalón CM, Contreras J, Ramírez-San Juan E, Castillo C, Perusquía M, Terrón JA (1995b) Characterization of prejunctional 5-HT receptors mediating inhibition of sympathetic vasopressor responses in the pithed rat. Br J Pharmacol 116: 3330-3336
35. 1-like receptor-mediated external carotid vasoconstriction in vagosympathectomized dogs. Ann NY Acad Sci (in press)
36. Villalón CM, Sánchez-López A, Centurión D (1996b) 5-HT receptors mediating the increases in external carotid blood flow in vagosympathectomized dogs pretreated with GR127935. Br J Pharmacol 117:45 P
37. 1D recognition sites: Radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's Arch Pharmacol 337: 595-601