Evidence for an age-dependent functional expression of α(1D)-adrenoceptors in the rat vasculature

European Journal of Pharmacology

Volumn 322, Issue 2-3, 1997, Pages 221-224

  Ibarra, Maximiliano ^a   Terrón, José A ^a   López Guerrero, Juan J ^a   Villalobos Molina, Rafael ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

1 Adrenoceptor, subtype; Aging; Blood pressure; BMY 7378; Pithed rat

Indexed keywords

5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1D ADRENERGIC RECEPTOR; CHLOROETHYLCLONIDINE; PHENYLEPHRINE; RECEPTOR SUBTYPE;

AGING; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESISTANCE BLOOD VESSEL;

ADRENERGIC ALPHA-ANTAGONISTS; AGING; ANIMALS; BLOOD PRESSURE; BLOOD VESSELS; CLONIDINE; MALE; PHENYLEPHRINE; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0030904326     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00092-7     Document Type: Article

References (15)

1. 1D subtype. Eur. J. Pharmacol. 297, 241-248.
2. Docherty, J.R., 1990. Cardiovascular responses in ageing: a review. Pharmacol. Rev. 42, 103-125.
3. 1c subtype. Mol. Pharmacol. 45, 703-708.
4. 1-adrenoceptors. Eur. J. Pharmacol. 272, R5-R6.
5. 1-Adrenoceptor responsiveness in the aging aorta. Eur. J. Pharmacol. 274, 117-123.
6. 1-adrenoceptor subtypes changes with age in the rat aorta. J. Pharmacol. Exp. Ther. 275, 1656-1662.
7. 1-adrenoceptors: consensus update. Pharmacol. Rev. 47, 267-270.
8. 1A subtype. Mol. Pharmacol. 46, 823-831.
9. 1-Adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat. Eur. J. Pharmacol. 186, 273-278.
10. Piascik, M.T., Smith, M.S., Barron, K.W., Soltis, E.E., 1993. The regulation of regional hemodynamics by alpha-1 adrenoceptor subtypes in the conscious rat. J. Pharmacol. Exp. Ther. 267, 1250-1255.
11. 1A,B-adrenoceptor subtypes in the pithed rat. J. Auton. Pharmacol. 12, 125-136.
12. Schwinn, D.A., Johnston, G.I., Page, S.O., Mosley, M.J., Wilson, K.H., Worman, N.P., Campbell, S., Fidock, M.D., Furness, L.M., Parry-Smith, D.J., Peter, B., Bailey, D.S., 1994. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J. Pharmacol. Exp. Ther. 272, 134-142.
13. Steel, R.G.D., Torrie, J.H., 1980. Principles and Procedures of Statistics, A Biomedical Approach. McGraw-Hill, Tokyo.
14. Tallarida, R.J., Murray, R.B., 1981. Manual of Pharmacological Calculations with Computer Programs. Springer, New York, NY.
15. 1D-adrenoceptors have a role in the presser response to phenylephrine in the pithed rat. Eur. J. Pharmacol. 305, 173-176.