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Volumn 65, Issue 1, 2004, Pages 77-84

Salvinal, a Novel Microtubule Inhibitor Isolated from Salvia miltiorrhizae Bunge (Danshen), with Antimitotic Activity in Multidrug-Sensitive and -Resistant Human Tumor Cells

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTIMITOTIC AGENT; CASPASE 3; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25C; COLCHICINE; CYCLIN B1; DNA FRAGMENT; ETOPOSIDE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; PROTEIN BCL 2; PROTEIN KINASE; SALVINAL; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 1642495631     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.1.77     Document Type: Article
Times cited : (97)

References (40)
  • 5
    • 0031032294 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
    • Decaudin D, Geley S, Hirsch T, Castedo M, Marchetti P, Macho A, Kofler R, and Kroemer G (1997) Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57:62-67.
    • (1997) Cancer Res , vol.57 , pp. 62-67
    • Decaudin, D.1    Geley, S.2    Hirsch, T.3    Castedo, M.4    Marchetti, P.5    Macho, A.6    Kofler, R.7    Kroemer, G.8
  • 6
    • 0031026679 scopus 로고    scopus 로고
    • Cell cycle: Will the real Cdk-activating kinase please stand up
    • Draetta GF (1997) Cell cycle: will the real Cdk-activating kinase please stand up. Curr Biol 7:R50-R52.
    • (1997) Curr Biol , vol.7
    • Draetta, G.F.1
  • 7
    • 0033052777 scopus 로고    scopus 로고
    • Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport and cell death
    • Dumontet C and Sikic BI (1999) Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport and cell death. J Clin Oncol 17:1061-1070.
    • (1999) J Clin Oncol , vol.17 , pp. 1061-1070
    • Dumontet, C.1    Sikic, B.I.2
  • 9
    • 0021166371 scopus 로고
    • A semiautomated microculture method for investigating growth inhibitory effects of cytotoxic compounds on exponentially growing carcinoma cells
    • Finlay GJ, Baguley BC, and Wilson WR (1984) A semiautomated microculture method for investigating growth inhibitory effects of cytotoxic compounds on exponentially growing carcinoma cells. Anal Biochem 139:272-277.
    • (1984) Anal Biochem , vol.139 , pp. 272-277
    • Finlay, G.J.1    Baguley, B.C.2    Wilson, W.R.3
  • 10
    • 0029954843 scopus 로고    scopus 로고
    • P-Glycoprotein - A mediator of multidrug resistance in tumour cells
    • Germann UA (1996) P-Glycoprotein-a mediator of multidrug resistance in tumour cells. Eur J Cancer 32A:927-944.
    • (1996) Eur J Cancer , vol.32 A , pp. 927-944
    • Germann, U.A.1
  • 12
    • 0029965897 scopus 로고    scopus 로고
    • Antimitotic natural products and their interactions with tubulin
    • Hamel E (1996) Antimitotic natural products and their interactions with tubulin. Med Res Rev 16:207-231.
    • (1996) Med Res Rev , vol.16 , pp. 207-231
    • Hamel, E.1
  • 13
    • 0027244234 scopus 로고
    • Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
    • Heald R, McLoughlin M, and Mckeon F (1993) Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74:463-474.
    • (1993) Cell , vol.74 , pp. 463-474
    • Heald, R.1    McLoughlin, M.2    Mckeon, F.3
  • 14
    • 0027509501 scopus 로고
    • Phosphorylation and activation of human Cdc25-C by Cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
    • Hoffmann I, Clarke PR, Marcote MJ, Karsenti E, and Draetta G (1993) Phosphorylation and activation of human Cdc25-C by Cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO (Eur Mol Biol Organ) J 12:53-63.
    • (1993) EMBO (Eur Mol Biol Organ) J , vol.12 , pp. 53-63
    • Hoffmann, I.1    Clarke, P.R.2    Marcote, M.J.3    Karsenti, E.4    Draetta, G.5
  • 15
    • 0032523959 scopus 로고    scopus 로고
    • Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound
    • Jiang JD, Wang Y, Roboz J, Strauchen J, Holland JF, and Bekesi JG (1998) Inhibition of microtubule assembly in tumor cells by 3-bromoacetylamino benzoylurea, a new cancericidal compound. Cancer Res 58:2126-2133.
    • (1998) Cancer Res , vol.58 , pp. 2126-2133
    • Jiang, J.D.1    Wang, Y.2    Roboz, J.3    Strauchen, J.4    Holland, J.F.5    Bekesi, J.G.6
  • 16
    • 0031872051 scopus 로고    scopus 로고
    • Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
    • Jordan A, Hadfield JA, Lawrence NJ, and McGown AT (1998) Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev 18:259-296.
    • (1998) Med Res Rev , vol.18 , pp. 259-296
    • Jordan, A.1    Hadfield, J.A.2    Lawrence, N.J.3    McGown, A.T.4
  • 17
    • 0030931827 scopus 로고    scopus 로고
    • Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes
    • Kavallaris M, Kuo DY, Burkhart CA, Regl DL, Norris MD, Haber M, and Horwitz SB (1997) Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Investig 100:1282-1293.
    • (1997) J Clin Investig , vol.100 , pp. 1282-1293
    • Kavallaris, M.1    Kuo, D.Y.2    Burkhart, C.A.3    Regl, D.L.4    Norris, M.D.5    Haber, M.6    Horwitz, S.B.7
  • 18
    • 0035422780 scopus 로고    scopus 로고
    • Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells
    • Kavallaris M, Tait AS, Walsh BJ, He L, Horwitz SB, Norris MD, and Haber M (2001) Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells. Cancer Res 61:5803-5809.
    • (2001) Cancer Res , vol.61 , pp. 5803-5809
    • Kavallaris, M.1    Tait, A.S.2    Walsh, B.J.3    He, L.4    Horwitz, S.B.5    Norris, M.D.6    Haber, M.7
  • 19
    • 0028956550 scopus 로고
    • Regulators of cell death
    • Korsmeyer SJ (1995) Regulators of cell death. Trends Genet 11:101-105.
    • (1995) Trends Genet , vol.11 , pp. 101-105
    • Korsmeyer, S.J.1
  • 20
    • 0025980359 scopus 로고
    • The Cdc25 protein controls tyrosine dephosphorylation of the Cdc2 protein in a cell-free system
    • Kumagai A and Dunphy WG (1991) The Cdc25 protein controls tyrosine dephosphorylation of the Cdc2 protein in a cell-free system. Cell 64:903-914.
    • (1991) Cell , vol.64 , pp. 903-914
    • Kumagai, A.1    Dunphy, W.G.2
  • 21
    • 0029895941 scopus 로고    scopus 로고
    • Synthesis of 5-(3-hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′ -hydroxyphenyl)-3-benzo[b]furancarbaldehyde, a novel adenosine A1 receptor ligand from the root of Salvia miltiorrhizae
    • Kuo Y-H and Wu C-H (1996) Synthesis of 5-(3-hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′-hydroxyphenyl) -3-benzo[b]furancarbaldehyde, a novel adenosine A1 receptor ligand from the root of Salvia miltiorrhizae. J Nat Prod (Lloydia) 59:625-628.
    • (1996) J Nat Prod (Lloydia) , vol.59 , pp. 625-628
    • Kuo, Y.-H.1    Wu, C.-H.2
  • 22
    • 0034997538 scopus 로고    scopus 로고
    • Two new fatty diterpenoids from Salvia miltiorrhizae
    • Lin H-C, Ding H-Y, and Chang W-L (2001) Two new fatty diterpenoids from Salvia miltiorrhizae. J Nat Prod (Lloydia) 64:648-650.
    • (2001) J Nat Prod (Lloydia) , vol.64 , pp. 648-650
    • Lin, H.-C.1    Ding, H.-Y.2    Chang, W.-L.3
  • 23
    • 0026601262 scopus 로고
    • Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes
    • Liu GT, Zhang TM, Wang BE, and Wang YW (1992) Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43:147-152.
    • (1992) Biochem Pharmacol , vol.43 , pp. 147-152
    • Liu, G.T.1    Zhang, T.M.2    Wang, B.E.3    Wang, Y.W.4
  • 24
    • 0026752669 scopus 로고
    • Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data
    • Paull KD, Lin CM, Malspeis L, and Hamel E (1992) Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. Cancer Res 52:3892-3900.
    • (1992) Cancer Res , vol.52 , pp. 3892-3900
    • Paull, K.D.1    Lin, C.M.2    Malspeis, L.3    Hamel, E.4
  • 25
    • 0032783884 scopus 로고    scopus 로고
    • Multidrug resistance in human tumors-molecular diagnosis and clinical significance
    • Ramachandran C and Melnick SJ (1999) Multidrug resistance in human tumors-molecular diagnosis and clinical significance. Mol Diagn 4:81-94.
    • (1999) Mol Diagn , vol.4 , pp. 81-94
    • Ramachandran, C.1    Melnick, S.J.2
  • 26
    • 0029973041 scopus 로고    scopus 로고
    • Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance
    • Ranganathan S, Dexter DW, Benetatos CA, Chapman AE, Tew KD, and Hudes GR (1996) Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance. Cancer Res 56:2584-2589.
    • (1996) Cancer Res , vol.56 , pp. 2584-2589
    • Ranganathan, S.1    Dexter, D.W.2    Benetatos, C.A.3    Chapman, A.E.4    Tew, K.D.5    Hudes, G.R.6
  • 28
    • 0026345003 scopus 로고
    • The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics
    • Rowinsky EK and Donehower RC (1991) The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics. Pharmacol Ther 52:35-84.
    • (1991) Pharmacol Ther , vol.52 , pp. 35-84
    • Rowinsky, E.K.1    Donehower, R.C.2
  • 29
    • 0029767016 scopus 로고    scopus 로고
    • Structural basis of cyclin-dependent kinase activation by phosphorylation
    • Russo AA, Jeffrey PD, and Pavletich NP (1996) Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat Struct Biol 3:696-700.
    • (1996) Nat Struct Biol , vol.3 , pp. 696-700
    • Russo, A.A.1    Jeffrey, P.D.2    Pavletich, N.P.3
  • 31
    • 0032514914 scopus 로고    scopus 로고
    • Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and taxol-induced growth arrest
    • Scatena CD, Stewart ZA, Mays D, Tang LJ, Keefer CJ, Leach SD, and Pietenpol JA (1998) Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and taxol-induced growth arrest. J Biol Chem 273:30777-30784.
    • (1998) J Biol Chem , vol.273 , pp. 30777-30784
    • Scatena, C.D.1    Stewart, Z.A.2    Mays, D.3    Tang, L.J.4    Keefer, C.J.5    Leach, S.D.6    Pietenpol, J.A.7
  • 32
    • 0000297058 scopus 로고
    • Taxol stabilizes microtubules in mouse fibroblast cells
    • Schiff PB and Horwitz SB (1980) Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA 77:1561-1565.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 1561-1565
    • Schiff, P.B.1    Horwitz, S.B.2
  • 35
    • 0028047288 scopus 로고
    • Cloning of CDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope
    • Westendorf JM, Rao PN, and Gerace L (1994) Cloning of CDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Proc Natl Acad Sci USA 91:714-718.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 714-718
    • Westendorf, J.M.1    Rao, P.N.2    Gerace, L.3
  • 36
    • 0035146128 scopus 로고    scopus 로고
    • The spindle: A dynamic assembly of microtubules and motors
    • Wittmann T, Hyman A, and Desai A (2001) The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol 3:E28-E34.
    • (2001) Nat Cell Biol , vol.3
    • Wittmann, T.1    Hyman, A.2    Desai, A.3
  • 37
    • 0026309074 scopus 로고
    • Cytotoxic activities of tanshinones against human carcinoma cell lines
    • Wu WL, Chang WL, and Chen CF (1991) Cytotoxic activities of tanshinones against human carcinoma cell lines. Am J Chin Med 19:207-216.
    • (1991) Am J Chin Med , vol.19 , pp. 207-216
    • Wu, W.L.1    Chang, W.L.2    Chen, C.F.3
  • 38
    • 0024502823 scopus 로고
    • Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements
    • Yagi A, Fujimoto K, Tanonaka K, Hirai K, and Takeo S (1989) Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements. Planta Med 55:51-54.
    • (1989) Planta Med , vol.55 , pp. 51-54
    • Yagi, A.1    Fujimoto, K.2    Tanonaka, K.3    Hirai, K.4    Takeo, S.5
  • 40
    • 0027049774 scopus 로고
    • Compounds from Danshen. Part 7. Regioselective introduction of carbon-3 substituents to 5-alkyl-7-methoxy-2-phenylbenzo[b]furans: Synthesis of a novel adenosine Al receptor ligand and its derivatives
    • Yang Z, Liu HB, Lee CM, Chang HM, and Wong HNC (1992) Compounds From Danshen. Part 7. Regioselective introduction of carbon-3 substituents to 5-alkyl-7-methoxy-2-phenylbenzo[b]furans: synthesis of a novel adenosine Al receptor ligand and its derivatives. J Org Chem 57:7248-7257.
    • (1992) J Org Chem , vol.57 , pp. 7248-7257
    • Yang, Z.1    Liu, H.B.2    Lee, C.M.3    Chang, H.M.4    Wong, H.N.C.5


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