Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation

Journal of Infectious Diseases

Volumn 193, Issue 7, 2006, Pages 1037-1046

  Li, Guo Qing ^a,b,d   Xia, Harry Hua Xiang ^a   Chen, Min Hu ^b   Gu, Qing ^a   Wang, Ji De ^a   Peng, Jun Zhong ^a   Chan, Annie O O ^a   Cho, Chi Hin ^a   So, Hau Leung ^a   Lam, Shiu Kum ^a   Hu, Pin Jin ^b   Liang, Ying Jie ^c   Lin, Han Liang ^c   Berg, Douglas E ^e   Feng, Zhe Hui ^f   Langenbach, Robert ^g   Wong, Benjamin Chun Yu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d THE SECOND AFFILIATED HOSPITAL OF UNIVERSITY OF SOUTH CHINA   (China)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^g NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; INTERLEUKIN 10; LEUKOTRIENE B4; LEUKOTRIENE C4; MESSENGER RNA; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; GASTRITIS; GENE DISRUPTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HETEROZYGOTE; HOMOZYGOTE; INOCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH EPITHELIUM; STOMACH MUCOSA; WILD TYPE;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTRIC MUCOSA; GASTRITIS; GENE EXPRESSION REGULATION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; INTERLEUKIN-10; LEUKOTRIENE B4; LEUKOTRIENE C4; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33645375383     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/500984     Document Type: Article

References (59)

1. Vane JR. Inhibition of prostaglandin biosynthesis as a mechanism of action of aspirin-like drugs. Nat New Biol 1971; 231:232-35.
2. Masferrer JL, Isakson PC, Seibert K. Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract. Gastroenterol Clin North Am 1996; 25:363-72.
3. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Schistosomes, liver flukes and Helicobacter pylori: Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum 1994; 61:1-241.
4. Fu S, Ramanujam KS, Wong A, et al. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori astritis. Gastroenterology 1999; 116:1319-29.
5. Gilroy DW, Tomlinson A, Willoughby DA. Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. Inflamm Res 1998; 47:79-85.
6. Tatsuguchi A, Sakamoto C, Wada K, et al. Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. Gut 2000; 46:782-9.
7. Feldman M, Cryer B, Mallat D, Go MF. Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial. Am J Gastroenterol 2001; 96:1751-7.
8. Publig W, Wustinger C, Zandl C. Non-steroidal anti-inflammatory drugs (NSAID) cause gastrointestinal ulcers mainly in Helicobacter pylori carriers. Wien Klin Wochenschr 1994; 106:276-9.
9. Santucci L, Fiorucci S, Patoia L, Di Matteo FM, Brunori PM, Morelli A. Severe gastric mucosal damage induced by NSAIDs in healthy subjects is associated with Helicobacter pylori infection and high levels of serum pepsinogens. Dig Dis Sci 1995; 40:2074-80.
10. Yoshida N, Sugimoto N, Hirayama F, et al. Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils. Gut 2002; 50:594-8.
11. Kim TI, Lee YC, Lee KH, et al. Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity. Infect Immun 2001; 69:5056-63.
12. Scheiman JM, Greenson JK, Lee J, Cryer B. Effect of cyclooxygenase-2 inhibition on human Helicobacter pylori gastritis: mechanisms underlying gastrointestinal safety and implications for cancer chemoprevention. Aliment Pharmacol Ther 2003; 17:1535-43.
13. Anti M, Armuzzi A, Gasbarrini A, Gasbarrini G. Importance of changes in epithelial cell turnover during Helicobacter pylori infection in gastric carcinogenesis. Gut 1998;43(Suppl 1):S27-32.
14. Correa P, Miller MJS. Carcinogenesis, apoptosis and cell proliferation. Br Med Bull 1998; 54:151-62.
15. Mannick EE, Bravo LE, Zarama G, et al. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res 1996; 56:3238-43.
16. Moss SF, Calam J, Agarwal B, Wang S, Holt PR. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut 1996; 38:498-501.
17. Ierardi E, Francavilla A, Balzano T, et al. Effect of Helicobacter pylori eradication on gastric epithelial proliferation, relationship with ras oncogene p21 expression. Ital J Gastroenterol Hepatol 1997; 29:214-9.
18. Que FG, Gores GJ. Cell death by apoptosis: basic concepts and disease relevance for the gastroenterologist. Gastroenterology 1996; 110:1238-43.
19. Moss SF. Cellular markers in the gastric precancerous process. Aliment Pharmacol Ther 1998; 12(Suppl 1):S91-109.
20. Karttunen R, Karttunen T, Ekre HP, MacDonald TT. Interferon-γ and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut 1995; 36:341-5.
21. D'Elios MM, Manghetti M, De Carli M, et al. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J Immunol 1997; 158:962-7.
22. Bamford KB, Fan X, Crowe SE, et al. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 1998; 114:482-92.
23. Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KT. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. J Immunol 2003; 171:3913-7.
24. Lehmann FS, Golodner EH, Wang J, et al. Mononuclear cells and cytokines stimulate gastrin release from canine antral cells in primary culture. Am J Physiol 1996; 270:G783-8.
25. Genta RM. The immunobiology of Helicobacter pylori gastritis. Semin Gastrointest Dis 1997; 8:2-11.
26. -/- mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol 2003; 170:3782-9.
27. Eaton KA, Mefford M, Thevenot T. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 2001; 166:7456-61.
28. 2. Am J Physiol Gastrointest Liver Physiol 2004; 286:G148-56.
29. Piazza GA, Alberts DS, Hlzson LJ, et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res 1997; 57:2909-15.
30. Zhu GH, Wong BC, Slosberg ED, et al. Overexpression of protein kinase C-beta1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology 2000; 118:507-14.
31. Wong BC, Jiang XH, Lin MC, et al. Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase. Gastroenterology 2004; 126:136-47.
32. Wong BC, Jiang X, Fan XM, et al. Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer. Oncogene 2003; 22:1189-97.
33. Elder DJ, Halton DE, Hague A, Paraskeva C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin Cancer Res 1997; 3:1679-83.
34. Langenbach R, Morham SG, Tiano HF, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995; 83:483-92.
35. Morham SG, Langenbach R, Loftin CD, et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995; 83:473-82.
36. Fukuda T, Kimura S, Arakawa T, Kobayashi K. Possible role of leukotrienes in gastritis associated with Campylobacter pylori. J Clin Gastroenterol 1990; 12(Suppl 1):S131-4.
37. Ahmed A, Holton J, Vaira D, Smith SK, Hoult JR. Eicosanoid synthesis and Helicobacter pylori associated gastritis: increase in leukotriene C4 generation associated with H. pylori colonization. Prostaglandins 1992; 44:75-86.
38. Huseyinov A, Kutukculer N, Aydogdu S, et al. Increased gastric production of platelet-activating factor, leukotriene-B4, and tumor necrosis factor-alpha in children with Helicobacter pylori infection. Dig Dis Sci 1999; 44:675-9.
39. Ballou LR, Bolting RM, Goorha S, Zhang J, Vane JR. Nociception in cyclooxygenase isozyme-deficient mice. Proc Natl Acad Sci USA 2000; 97:10272-6.
40. Xia HHX, Lam SK, Lin MCM, et al. Macrophage migration inhibitory factor stimulated by Helicobacter pylori increases proliferation of gastric epithelial cells. World J Gastroenterol 2005; 11:1946-50.
41. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998; 115:642-8.
42. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. Am J Surg Pathol 1996; 20:1161-81.
43. Futagami S, Hiratsuka T, Wada K, et al. Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils. Aliment Pharmacol Ther 2002; 16:847-55.
44. Takahashi S, Fujita T, Yamamoto A. Role of cyclooxygenase-2 in Helicobacter pylori-induced gastritis in Mongolian gerbils. Am J Physiol Gastrointest Liver Physiol 2000; 279:G791-8.
45. Fraser AG, Sim R, Sankey EA, Dhillon AP, Pounder RE. Effect of eradication of Helicobacter pylori on gastric epithelial cell proliferation. Aliment Pharmacol Ther 1994; 8:167-73.
46. Peek RM Jr, Wirth HP, Moss SF, et al. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology 2000; 118:48-59.
47. Peek RM Jr, Moss SF, Tham KT, et al. Helicobacter pylori cagA1 strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer Inst 1997; 89:863-8.
48. Xia HH, Talley NJ. Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis. Am J Gastroenterol 2001; 96:16-26.
49. Jones NL, Shannon PT, Cutz E, Yeger H, Sherman PM. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am J Pathol 1997; 151:1695-703.
50. Wang WH, Huang JQ, Zheng GF, Lam SK, Karlberg J, Wong BC. Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. J Natl Cancer Inst 2003; 95:1784-91.
51. Thun MJ, Namboodiri MM, Calle EE, Flanders WD, Heath CW Jr. Aspirin use and risk of fatal cancer. Cancer Res 1993; 53:1322-7.
52. Jones MK, Wang H, Peskar BM, et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 1999; 5:1418-23.
53. Shiff SJ, Qiao L, Tsai LL, Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Investig 1995; 96:491-503.
54. Zhu GH, Wong BC, Eggo MC, et al. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br J Cancer 1999; 79:393-400.
55. 1-dependent pathway. Oncogene 2002; 21:6113-22.
56. Zhou XM, Wong BC, Fan XM, et al. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis 2001; 22:1393-7.
57. Kirtikara K, Morham SG, Raghow R, et al. Compensatory prostaglandin E2 biosynthesis in cyclooxygenase 1 or 2 null cells. J Exp Med 1998; 187:517-23.
58. Yamaoka Y, Yamauchi K, Ota H, et al. Natural history of gastric mucosal cytokine expression in Helicobacter pylori gastritis in Mongolian gerbils. Infect Immun 2005; 73:2205-12.
59. Andersen LP, Holck S, Janulaityte-Gunther D, et al. Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. FEMS Immunol Med Microbiol 2005; 44:233-8.