Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation

Inflammation Research

Volumn 47, Issue 2, 1998, Pages 79-85

  Gilroy, D W ^a   Tomlinson, A ^a   Willoughby, D A ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Chronic inflammation; Cyclooxygenase 1; Cyclooxygenase 2; Nonsteroidal anti inflammatory drugs

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FREUND ADJUVANT; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INHIBITION; FEMALE; GRANULOMA; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; VASCULARIZATION;

AIR; AIR SACS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CROTON OIL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; FREUND'S ADJUVANT; GRANULOMA; ISOENZYMES; MEMBRANE PROTEINS; MICE; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SULFONAMIDES;

EID: 0031881410     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050285     Document Type: Article

References (41)

1. Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsiveness gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6.
2. Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR. TIS10, a phorhol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 1991;266: 12866-72.
3. Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, et al. Inducible isoforms ofcyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA 1994;91:2046-50.
4. Tomlinson A, Appleton I, Moore AR, Gilroy DW, Willis D, Mitchell JA, et al. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br J Pharmacol 1994;113:693-8.
5. Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993;268:6610-4.
6. Bateman DN. NSAIDs: Time to re-evaluate gut toxicity [comment]. Lancet 1994;343:1051-2.
7. Edwards JC, Sedgwick AD, Willoughby DA. The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system. J Pathol 1981;134:147-56.
8. Sedgwick AD, Moore AR, Al-Duaij AY, Edwards JC, Willoughby DA. Studies into the influence of carrageenan-induced inflammation on articular cartilage degradation using implantation into air pouches. Br J Exp Pathol 1985;66:445-53.
9. Sedgwick AD, Moore AR, Al-Duaij AY, Edwards JC, Willoughby DA. The immune response to pertussis in the 6-day air pouch: A model of chronic synovitis. Br J Exp Pathol 1985;66:455-64.
10. De Brito FB, Moore AR, Adhya S, Al-Duaij AY, Willoughby DA. Adjuvant polyarthritis and the response of air pouch lining cells. Int J Tissue React 1986;8:289-94.
11. Kimura M, Suzuki J, Amemiya K. Mouse granuloma pouch induced by Freund's complete adjuvant with croton oil. J Pharmacobiodyn 1985;8:393-400.
12. Appleton I, Tomlinson A, Colville-Nash PR, Willoughby DA, Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes. Lab Invest 1993;69:405-14.
13. Appleton I, Tomlinson A, Mitchell JA, Willoughby DA. Distribution of cyclooxygenase isoforms in murine chronic granulomatous inflammation. Implications for future anti-inflammatory therapy. J Pathol 1995;176:413-20.
14. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 1993;90:11693-7.
15. Grossman CJ, Wiseman J, Lucas FS, Trevethick MA, Birch PJ. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and COX-2 inhibitors. Inflamm Res 1995;44:253-7.
16. Futaki N, Takahashi S, Yokoyama M, Aral I, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994;47:55-9.
17. Battistini B, Botting R, Bakhle YS, COX-1 and COX-2: Towards the development of more selective NSAIDs. Drug News Perspect 1994;7:501-12.
18. Tavares IA, Bishai PM, Bennett A. Activity of nimesulide on constitutive and inducible cyclooxygenases. Arzneimittelforschung 1995;45:1093-5.
19. Rufer C, Schillinger E, Bottcher I, Repenthin W, Herrmann C. Non-steroidal anti-inflammatories-XII. Mode of action of antiinflammatory methane sulfonanilides. Biochem Pharmacol 1982;31:3591-6.
20. Maffei Facino R, Carini M, Aldini G, Saibene L, Morelli R. Differential inhibition of superoxide, hydroxyl and peroxyl radicals by nimesulide and its main metabolite 4-hydroxynimesulide. Arzneimittelforschung 1995;45:1102-9.
21. Maffei Facino R, Carini M, Aldini G, Saibene L, Macciocchi A. Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model. Int J Tissue React 1993;15:225-34.
22. Lu X, Xie W, Reed D, Bradshaw WS, Simmons DL. Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Proc Natl Acad Sci USA 1995;92:7961-5.
23. Wilborn J, De Witt DL, Peters-Golden M. Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages. Am J Physiol 1995;268:L294-301.
24. Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995;83:473-82.
25. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986;83:4167-71.
26. 1 on collagen production and degradation in human fetal lung fibroblasts. Arch Biochem Biophys 1988;265:441-6.
27. Fine A, Panchenko MP, Smith BD, Yu Q, Goldstein RH. Discordant regulation of transforming growth factor-beta receptors by prostaglandin E2. Biochim Biophys Acta 1995;1261:19-24.
28. 2 but not procollagen synthesis via a pertussis toxin-sensitive G-protein. Biochem J 1995;307:63-8.
29. Frucht J, Zauberman H. Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels. Br J Ophthalmol 1984;68:656-9.
30. BenEzra D. Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants. Am J Ophthalmol 1978; 86:455-61.
31. Spisni E, Manica F, Tomasi V. Involvement of prostanoids in the regulation of angiogenesis by polypeptide growth factors. Prostaglandins Leukot Essent Fatty Acids 1992;47:111-5.
32. Ben-Av P, Crofford LJ, Wilder RL, Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: A potential mechanism for inflammatory angiogenesis. FEBS Lett 1995;372:83-7.
33. Appleton I, Brown NJ, Willis D, Colville-Nash PR, Alam C, Brown JR, et al. The role of vascular endothelial growth factor in a murine chronic granulomatous tissue air pouch model of angiogenesis. J Pathol 1996;180:90-4.
34. Colville-Nash PR, Alam CA, Appleton I, Brown JR, Seed MP, Willoughby DA. The pharmacological modulation of angiogenesis in chronic granulomatous inflammation. J Pharmacol Exp Ther 1995;274:1463-72.
35. Colville-Nash PR, el-Ghazaly M, Willoughby DA. The use of angiostatic steroids to inhibit cartilage destruction in an in vivo model of granuloma-mediated cartilage degradation. Agents Actions 1993;38:126-34.
36. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 1994;91:3228-32.
37. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 1993;24:105-10.
38. Anderson GD, Hauser SD, Mcgarity KL, Bremer ME, Isakson PC, Gregory SA. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest 1996;97:2672-9.
39. Berg J, Fellier H, Bodenteich A, Christoph T, Towart R. Selective prostaglandin G/H synthase (PGHS)-2 inhibitors show greater inhibitory activities on human PGHS-2 than on murine PGHS-2 in intact cells. Immunopharmacology 1997;5: 119-26.
40. Hubbard RC, Mehlisch DR, Jasper DR, Nugent MJ, YU S, Isakson PC. SC-58125, A highly selective inhibitor of COX-2 is an effective analgesic in an acute post-surgical pain model. J Invest Med 1996;44:293.
41. Crofford LJ, Wilder RL, Ristamaki AP, Sano H, Remmers EF, Epps HR, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues: Effects of interleukin-1 beta, phorbol esters and corticosteroids. J Clin Invest 1994;93:1095-101.