Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species

Journal of Infectious Diseases

Volumn 193, Issue 7, 2006, Pages 1014-1022

  Chamilos, Georgios ^a   Lionakis, Michail S ^a   Lewis, Russell E ^a,b   Lopez Ribot, Jose L ^c   Saville, Stephen P ^c   Albert, Nathaniel D ^a   Halder, Georg ^a   Kontoyiannis, Dimitrios P ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; DOXYCYCLINE; FLUCONAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CANDIDA ALBICANS; CANDIDIASIS; CAUSE OF DEATH; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG EFFICACY; DRUG SENSITIVITY; FEMALE; FUNGAL VIRULENCE; HOST; IMMUNE DEFICIENCY; MUTANT; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA; CANDIDIASIS; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DRUG RESISTANCE, FUNGAL; FEMALE; FLUCONAZOLE; FUNGAL PROTEINS; MUTATION; REPRESSOR PROTEINS; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS; VIRULENCE; VIRULENCE FACTORS;

EID: 33645360264     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/500950     Document Type: Article

References (33)

1. Calderone R. Candida and candidiasis. Washington, DC: American Society of Microbiology, 2002.
2. Pappas PG, Rex JH, Lee J, et al. NIAID Mycoses study group. A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin Infect Dis 2003; 37:634-43.
3. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmonds MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39:309-17.
4. Gudlaugsson O, Gillespie S, Lee K, et al. Attributable mortality of nosocomial candidemia, revised. Clin Infect Dis 2003; 37:1172-7.
5. Pappas PG, Rex JH, Sobel JD, et al. Guidelines for treatment of candidiasis. Clin Infect Dis 2004; 38:161-89.
6. Baran J Jr, Muckarita B, Khatib R. Candidemia before and during the fluconazole era: prevalence, type of species and approach to treatment in a tertiary care community hospital. Scand J Infect Dis 2001; 33:137-9.
7. Krcmery V, Barnes AJ. Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance. J Hosp Infect 2002; 50:243-60.
8. Fonzi WA, Irwin MY. Isogenic strain construction and gene mapping in Candida albicans. Genetics 1993; 134:717-28.
9. Lo JH, Kohler JR, Di Domenico B, Loebenberg D, Cacciapuoti A, Fink GR. Nonfilamentous C. albicans mutants are avirulent. Cell 1997; 90:939-49.
10. Nakayama H, Mio T, Nagahashi S, Kokado M, Arisawa M, Aoki Y. Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans. Infect Immun 2000; 68:6712-9.
11. Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell 2003; 2:1053-60.
12. Liu H, Kohler J, Fink GR. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 1994; 266:1723-6.
13. Lewis RE, Lo HJ, Raad II, Kontoyiannis DP. Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth. Antimicrob Agents Chemother 2002; 46:1153-5.
14. Liu H. Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 2001; 4:728-35.
15. Zheng X, Wang Y, Wang Y. Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis. EMBO J 2004; 23:1845-56.
16. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86:973-83.
17. Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential expression of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997; 94:14614-9.
18. Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB. Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. Proc Natl Acad Sci USA 2002; 99:15675-80.
19. Vodovar N, Acosta C, Lemaitre B, Boccard F, Drosophila: a polyvalent model to decipher host-pathogen interactions. Trends Microbiol 2004; 12:235-42.
20. Lionakis MS, Lewis RE, May GS, et al. Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J Infect Dis 2005; 191:1188-95.
21. Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E. Challenge of Drosophila melanogaster with Cryptococcus neoformans and the role of the innate immune response. Eukaryot Cell 2004; 3:413-9.
22. Alarco AM, Marcil A, Chen J, Suter B, Thomas D, Whiteway M. Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens. J Immunol 2004; 172:5622-8.
23. Ashman RB, Fulurija A, Papadimitriou JM. Strain-dependent differences in host response to Candida albicans in mice are related to organ susceptibility and infectious load. Infect Immun 1996; 64:1866-9.
24. Kontoyiannis DP, Lewis RE. Antifungal drug resistance of pathogenic fungi. Lancet 2002; 359:1135-44.
25. NCCLS. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard, 2nd ed. NCCLS document M27-A2. Wayne, PA: NCCLS, 2002.
26. Brennan M, Thomas DY, Whiteway M, Kavanagh K. Correlation between virulence of Candida albicans mutants in mice and Galleria mellonela larvae. FEMS Immunol Med Microbiol 2002; 34:153-7.
27. Jones T, Federspiel NA, Chibana H, et al. The diploid genome sequence of Candida albicans. Proc Nat Acad Sci USA 2004; 101:7329-34.
28. Uhl MA, Biery M, Craig N, Johnson AD. Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J 2003; 22:2668-78.
29. Navarro-Garcia F, Sanchez M, Nombela C, Pla J. Virulence genes in the pathogenic yeast Candida albicans. FEMS Microbiol Rev 2001; 25:245-68.
30. Mylonakis E, Idnum A, Moreno R, et al. Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mol Microbiol 2004; 54:407-19.
31. Bae T, Banger AK, Wallace A, et al. Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proc Natl Acad Sci USA 2004; 101:12312-7.
32. Manev H, Dimitrijevic N, Dzitoyeva S. Techniques: fruit flies as models for neuropharmacological research. Trends Pharmacol Sci 2003; 24:41-3.
33. Mylonakis E, Aballay A. Worms and flies are genetically tractable animal models to study host-pathogen interactions. Infect Immun 2005; 73:3833-41.