Hgs physically interacts with Smad5 and attenuates BMP signaling

Experimental Cell Research

Volumn 312, Issue 7, 2006, Pages 1153-1163

  Haag, Jochen ^a,c   Chubinskaya, Susan ^b   Aigner, Thomas ^a,c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b RUSH MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

BMP; Cartilage; Hgs; Osteoarthritis; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COMPLEMENTARY DNA; PROTEIN HGS; SCATTER FACTOR; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ARTICULAR CARTILAGE; ATTENUATION; CARTILAGE CELL; CELL ACTIVITY; CELL DIFFERENTIATION; CELL INTERACTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MODULATION; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 33645283335     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.01.019     Document Type: Article

References (48)

1. T. Aigner, and L.A. McKenna Molecular pathology and pathobiology of osteoarthritic cartilage Cell. Mol. Life Sci. 59 2002 5 18
2. S. Chubinskaya, C. Merrihew, G. Cs-Szabó, J. Mollenhauer, J. McCartney, D.C. Rueger, and K.E. Kuettner Human articular chondrocytes express osteogenic protein-1 J. Histochem. Cytochem. 48 2000 239 250
3. J. Flechtenmacher, K. Huch, E.J.M.A. Thonar, J. Mollenhauer, S.R. Davies, T. Schmid, W. Puhl, T.K. Sampath, M.B. Aydelotte, and K.E. Kuettner Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes Arthritis Rheum. 39 1996 1896 1904
4. Z. Fan, S. Chubinskaya, D. Rueger, B. Bau, J. Haag, and T. Aigner Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1 Clin. Exp. Rheumatol. 22 2004 103 106
5. K. Huch, B. Wilbrink, J. Flechtenmacher, H. Koepp, M.B. Aydelotte, K.T. Sampath, K. Kuettner, J. Mollenhauer, and E.J.M.A. Thonar Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandine E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1β Arthritis Rheum. 40 1997 2157 2161
6. S. Soeder, A. Hakimiyan, D. Rueger, K. Kuettner, T. Aigner, and S. Chubinskaya Antisense inhibition of osteogenic protein-1 disturbs human articular cartilage integrity Arthritis Rheum. 52 2005 468 478
7. T. Imamura, M. Takase, A. Nishihara, E. Oeda, J. Hanai, M. Kawabata, and K. Miyazono Smad 6 inhibits signalling by the TGF-β superfamily Nature 389 1997 622 626
8. A. Nakao, M. Afrakhte, A. Moren, T. Nakayama, J.L. Christian, R. Heuchel, S. Itoh, M. Kawabata, N.-E. Heldin, C.-H. Heldin, and P. Ten Dijke Identification of Smad 7, a TGF-β-inducible antagonist of TGF-β signalling Nature 389 1997 631 635
9. Y. Shi, and J. Massague Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 2003 685 700
10. M. Kaiser, J. Haag, S. Söder, B. Bau, and T. Aigner BMP- and TGFβ-inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and differentially regulated in vitro by Il-1β Arthritis Rheum. 11 2004 3535 3540
11. B. Bau, J. Haag, E. Schmid, M. Kaiser, P.M. Gebhard, and T. Aigner Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes, but not upregulated or downregulated in osteoarthritic cartilage J. Bone Miner. Res. 17 12 2002 2141 2150
12. J. Ryu, B.V. Treadwell, and H.J. Mankin Biochemical and metabolic abnormalities in normal and osteoarthritic human articular cartilage Arthritis Rheum. 27-1 1984 49 57
13. T. Aigner, W. Bertling, H. Stoss, G. Weseloh, and K. von der Mark Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage J. Clin. Invest. 91 1993 829 837
14. L. Hambach, D. Neureiter, G. Zeiler, T. Kirchner, and T. Aigner Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage Arthritis Rheum. 41 1998 986 996
15. T. Aigner, H. Stoss, G. Weseloh, G. Zeiler, and K. von der Mark Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage Virchows Arch., B Cell Pathol. Incl. Mol. Pathol. 62 1992 337 345
16. L. Lippiello, M.D. Hall, and H.J. Mankin Collagen synthesis in normal and osteoarthrotic human cartilage J. Clin. Invest. 59 1977 593 600
17. D.R. Eyre, C.A. McDevitt, M.E.J. Billingham, and H. Muir Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis Biochem. J. 188 1980 823 837
18. H.J. Mankin, M.E. Johnson, and L. Lippiello Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips: III. Distribution and metabolism of amino sugar-containing macromolecules J. Bone Jt. Surg. 63-A-1 1981 131 139
19. T. Aigner, S.I. Vornehm, G. Zeiler, J. Dudhia, K. von der Mark, and M.T. Bayliss Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage Arthritis Rheum. 40 1997 562 569
20. K. Miyazono, K. Kusanagi, and H. Inoue Divergence and convergence of TGF-beta/BMP signaling J. Cell. Physiol. 187 2001 265 276
21. C.S. Hill The smads Int. J. Biochem. Cell Biol. 31 1999 1249 1254
22. M.B. Goldring, J.R. Birkhead, L.F. Suen, R. Yamin, S. Mizuno, J. Glowacki, J.L. Arbiser, and J.-F. Apperley Interleukin-1-modulated gene expression in immortalized human chondrocytes J. Clin. Invest. 94 1994 2307 2316
23. F. Finger, C.M. Schörle, A. Zien, P.M. Gebhard, M.B. Goldring, and T. Aigner Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, C-28/I2 Arthritis Rheum. 48 2003 3395 3403
24. M. Takigawa, K. Tajima, H.-O. Pan, M. Enomoto, A. Kinoshita, F. Suzuki, Y. Takano, and Y. Mori Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes Cancer Res. 49 1989 3996 4002
25. J. Saas, K. Lindauer, B. Bau, M. Takigawa, and T. Aigner Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes Osteoarthr. Cartil. 12 2004 924 934
26. T. Aigner, A. Zien, A. Gehrsitz, P.M. Gebhard, and L.A. McKenna Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology Arthritis Rheum. 44 2001 2777 2789
27. B. Bau, P.M. Gebhard, J. Haag, T. Knorr, E. Bartnik, and T. Aigner Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro Arthritis Rheum. 46 2002 2648 2657
28. L.A. McKenna, A. Gehrsitz, S. Soeder, W. Eger, T. Kirchner, and T. Aigner Effective isolation of high quality total RNA from human adult articular cartilage Anal. Biochem. 286 2000 80 85
29. L.J.C. Jonk, S. Itoh, C.-H. Heldin, P. Ten Dijke, and W. Kruijer Identification and functional characterization of a smad binding elements (sbe) in the junB promoter that acts as a transforming growth factor-β activin, and bone morphogenetic protein-inducible enhancer J. Biol. Chem. 273 1998 21145 21152
30. T. Aigner, D. Neureiter, S. Müller, G. Küspert, J. Belke, and T. Kirchner Extracellular matrix composition and gene expression in collagenous colitis Gastroenterology 113 1997 136 143
31. A. Gehrsitz, L.A. McKenna, S. Soeder, T. Kirchner, and T. Aigner Isolation of RNA from small human articular cartilage specimens allows quantification of mRNA expression levels in local articular cartilage defects J. Orthop. Res. 19 2001 478 482
32. S. Miura, T. Takeshita, H. Asao, Y. Kimura, K. Murata, Y. Sasaki, J.I. Hanai, H. Beppu, T. Tsukazaki, J.L. Wrana, K. Miyazono, and K. Sugamura Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA Mol. Cell. Biol. 20 2000 9346 9355
33. M. Komada, R. Masaki, A. Yamamoto, and N. Kitamura Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes J. Biol. Chem. 272 1997 20538 20544
34. S. Kunzmann, J.G. Wohlfahrt, S. Itoh, H. Asao, M. Komada, C.A. Akdis, K. Blaser, and C.B. Schmidt-Weber SARA and Hgs attenuate susceptibility to TGF-beta1-mediated T cell suppression FASEB J. 17 2003 194 202
35. D. Goto, H. Nakajima, Y. Mori, K. Kurasawa, N. Kitamura, and I. Iwamoto Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling Biochem. Biophys. Res. Commun. 281 2001 1100 1105
36. C. Raiborg, and H. Stenmark Hrs and endocytic sorting of ubiquitinated membrane proteins Cell Struct. Funct. 27 2002 403 408
37. C.K. Raymond, I. Howald-Stevenson, C.A. Vater, and T.H. Stevens Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants Mol. Biol. Cell 3 1992 1389 1402
38. M. Komada, and P. Soriano Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis Genes Dev. 13 1999 1475 1485
39. T.E. Lloyd, R. Atkinson, M.N. Wu, Y. Zhou, G. Pennetta, and H.J. Bellen Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila Cell 108 2002 261 269
40. C.X. Sun, C. Haipek, D.R. Scoles, S.M. Pulst, M. Giovannini, M. Komada, and D.H. Gutmann Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate Hum. Mol. Genet. 11 2002 3167 3178
41. D.R. Scoles, D.P. Huynh, M.S. Chen, S.P. Burke, D.H. Gutmann, and S.M. Pulst The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate Hum. Mol. Genet. 9 2000 1567 1574
42. L.S. Chin, M.C. Raynor, X. Wei, H.Q. Chen, and L. Li Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor J. Biol. Chem. 276 2001 7069 7078
43. C. Raiborg, K.G. Bache, A. Mehlum, E. Stang, and H. Stenmark Hrs recruits clathrin to early endosomes EMBO J. 20 2001 5008 5021
44. Y. Li, L.S. Chin, A.I. Levey, and L. Li Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking J. Biol. Chem. 277 2002 28212 28221
45. L. Lu, M. Komada, and N. Kitamura Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17 Gene 213 1998 125 132
46. H. Asao, Y. Sasaki, T. Arita, N. Tanaka, K. Endo, H. Kasai, T. Takeshita, Y. Endo, T. Fujita, and K. Sugamura Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth J. Biol. Chem. 272 1997 32785 32791
47. C. Raiborg, K.G. Bache, D.J. Gillooly, I.H. Madshus, E. Stang, and H. Stenmark Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes Nat. Cell Biol. 4 2002 394 398
48. N. Fukui, Y. Zhu, W.J. Maloney, J. Clohisy, and L.J. Sandell Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes J. Bone Jt. Surg., Am. 85-A Suppl. 3 2003 59 66