The BASH/BLNK/SLP-65-associated protein BNAS1 regulates antigen-receptor signal transmission in B cells

International Immunology

Volumn 18, Issue 4, 2006, Pages 545-553

  Katahira, Takashi ^a   Imamura, Yasuhiro ^a,b   Kitamura, Daisuke ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

B cell receptor; Elk 1; Leucine zipper; Mitogen activated protein kinase; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE RECEPTOR; LEUCINE ZIPPER PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BASH; PROTEIN BLNK; PROTEIN BNAS1; PROTEIN SLP 65; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BLOTTING, WESTERN; CARRIER PROTEINS; CELL NUCLEUS; CHICKENS; ENDOPLASMIC RETICULUM; ETS-DOMAIN PROTEIN ELK-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE TARGETING; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33645237105     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh395     Document Type: Article

References (29)

1. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
2. Reth, M. and Wienands, J. 1997. Initiation and processing of signals from the B cell antigen receptor. Annu. Rev. Immunol. 15:453.
3. Kurosaki, T. 2002. Regulation of B-cell signal transduction by adaptor proteins. Nat. Rev. Immunol. 2:354.
4. Campbell, K. S. 1999. Signal transduction from the B cell antigen-receptor. Curr. Opin. Immunol. 11:256.
5. Fu, C., Turck, C. W., Kurosaki, T. and Chan, A. C. 1998. BLNK: A central linker protein in B cell activation. Immunity 9:93.
6. Wienands, B. J., Schweikert, J., Wollscheid, B., Jumaa, H., Nielson, P. and Reth, M. 1998. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J. Exp. Med. 188:791.
7. Goitsuka, R., Fujimura, Y., Mamada, H. et al. 1998. BASH, a novel signaling molecule preferentially expressed in B cells of the Bursa of fabricius. J. Immunol. 161:5804.
8. Ishiai, M., Kurosaki, M., Pappu, R. et al. 1999. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells. Immunity 10:117.
9. Pappu, R., Cheng, A. M., Li, B. et al. 1999. Requirement for B cell linker protein (BLNK) in B cell development. Science 286:1949.
10. Jumaa, H., Wollscheid, B., Mitterer, M., Wienands, J., Reth, M. and Nielsen, P. J. 1999. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11:547.
11. Hayashi, K., Nittono, R., Okamoto, N. et al. 2000. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl Acad. Sci. USA 97:2755.
12. Xu, S., Tan, J. E., Wong, E. P., Manickam, A., Ponniah, S. and Lam, K. P. 2000. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int. Immunol. 12:397.
13. Minegishi, Y., Rohrer, J., Coustan-Smith, E. et al. 1999. An essential role for BLNK in human B cell development. Science 286:1954.
14. Hashimoto, S., Iwamatsu, A., Ishiai, M. et al. 1999. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 94:2357.
15. Chiu, C. W., Dalton, M., Ishiai, M., Kurosaki, T. and Chan, A. C. 2002. BLNK: Molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J. 21:6461.
16. Johmura, S., Oh-hora, M., Inabe, K. et al. 2003. Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK. Immunity 18:777.
17. Tsuji, S., Okamoto, M., Yamada, K. et al. 2001. B cell adaptor containing Src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. J. Exp. Med. 194:529.
18. Kohler, F., Storch, B., Kulathu, Y. et al. 2005. A leucine zipper in the N terminus confers membrane association to SLP-65. Nat. Immunol. 6:204.
19. Tan, J. E., Wong, S. C., Gan, S. K., Xu, S. and Lam, K. P. 2001. The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes. J. Biol. Chem. 276:20055.
20. Imamura, Y., Katahira, T. and Kitamura, D. 2004. Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. J. Biol. Chem. 279:26425.
21. Morimura, T., Goitsuka, R., Zhang, Y., Saito, I., Reth, M. and Kitamura, D. 2000. Cell cycle arrest and apoptosis induced by Notch1 in B cells. J. Biol. Chem. 275:36523.
22. Goitsuka, R., Kanazashi, H., Sasanuma, H. et al. 2000. A BASH/ SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degradation. Int. Immunol. 12:573.
23. Arakawa, H., Lodygin, D. and Buerstedde, J. M. 2001. Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol. 1:7.
24. Wu, H., Liu, G., Li, C. and Zhao, S. 2003. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. Biochem. Biophys. Res. Commun. 311:518.
25. Lin, L., Wu, Y., Li, C. and Zhao, S. 2001. Cloning, tissue expression pattern, and chromosome location of a novel human gene BRI3BP. Biochem. Genet. 39:369.
26. Flemming, A., Brummer, T., Reth, M. and Jumaa, H. 2003. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat. Immunol. 4:38.
27. Hayashi, K., Yamamoto, M., Nojima, T., Goitsuka, R. and Kitamura, D. 2003. Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity 18:825.
28. Vickers, E. R., Kasza, A., Kurnaz, I. A. et al. 2004. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol. Cell. Biol. 24:10340.
29. Baba, T. W., Giroir, B. P. and Humphries, E. H. 1985. Cell lines derived from avian lymphomas exhibit two distinct phenotypes. Virology 144:139.