Formation of 4′-carboxyl acid metabolite of imrecoxib by rat liver microsomes

Acta Pharmacologica Sinica

Volumn 27, Issue 4, 2006, Pages 506-512

  Xu, Hai Yan ^a   Zhang, Peng ^a   Gong, Ai Shen ^b   Sun, Yu Ming ^a   Chu, Feng Ming ^c   Guo, Zong Ru ^c   Zhong, Da Fang ^a,d  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Shanghai Hengrui Pharmaceuticals Co Ltd   (China)

^c INSTITUTE OF MATERIA MEDICA   (China)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytochrome P450; Imrecoxib; Liver microsomes; Metabolism; Rats

Indexed keywords

ALPHA NAPHTHOFLAVONE; BAP 910; CARBOXYLCELECOXIB; CELECOXIB; CIMETIDINE; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; DEXAMETHASONE; DRUG METABOLITE; HYDROXYLCELECOXIB; IMRECOXIB; ISONIAZID; KETOCONAZOLE; METHYLPYRAZOLE; PHENOBARBITAL; PYRAZOLE DERIVATIVE; QUININE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; CYTOCHROME P450 3A; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRROLE DERIVATIVE; SULFIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSFORMATION; ENZYME KINETICS; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MICHAELIS CONSTANT; NONHUMAN; RAT; REACTION OPTIMIZATION; ANIMAL; BIOTRANSFORMATION; DRUG ANTAGONISM; METABOLISM; WISTAR RAT;

ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; KETOCONAZOLE; MALE; MICROSOMES, LIVER; NADP; PYRROLES; RATS; RATS, WISTAR; SULFIDES;

EID: 33645224987     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00312.x     Document Type: Article

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