Pimary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability

Journal of Pathology

Volumn 208, Issue 5, 2006, Pages 643-652

  Guenot, Dominique ^a,d   Guerin E ^a   Aguillon Romain, S ^a   Pencreach, E ^a   Schneider, A ^b   Neuville, A ^b   Chenard, M P ^b   Duluc, I ^a   Du Manoir, S ^c   Brigand, C ^b   Oudet, P ^b   Kedinger, M ^a   Gaub, M P ^a  

^a INSERM   (France)

^b HÔPITAL DE HAUTEPIERRE   (France)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Allelotyping; Chromosome instability; Colon cancer; Comparative genome hybridization; Nude mouse; Tumour heterogeneity; Xenograft

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STAGING; CANCER TRANSPLANTATION; CHROMOSOMAL INSTABILITY; CLONAL VARIATION; COLON CANCER; COLON CARCINOGENESIS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE LOCUS; GENE MUTATION; GENETIC DISORDER; GENETIC HETEROGENEITY; GENETIC SCREENING; GENETIC STABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SCORING SYSTEM; TUMOR XENOGRAFT; ALLELIC IMBALANCE; ANIMAL; CELL TRANSFORMATION; COLON TUMOR; DISEASE MODEL; GENETICS; METHODOLOGY; NUCLEIC ACID HYBRIDIZATION; PATHOLOGY; XENOGRAFT;

DNA;

ALLELIC IMBALANCE; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA, NEOPLASM; GENETIC HETEROGENEITY; HUMANS; LOSS OF HETEROZYGOSITY; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NUCLEIC ACID HYBRIDIZATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 33645224968     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1936     Document Type: Article

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