Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma

International Journal of Cancer

Volumn 93, Issue 3, 2001, Pages 346-352

  Baisse, Bénédicte ^a   Bouzourene, Hanifa ^a   Saraga, Emilia P ^a   Bosman, Fred T ^a   Benhattar, Jean ^a,b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Colorectal cancer; Heterogeneity; K ras mutation; Loss of heterozygosity; P53 mutation

Indexed keywords

PROTEIN P53;

ADENOCARCINOMA; ADVANCED CANCER; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CHROMOSOME MICRODISSECTION; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION FUNCTION; DIAGNOSTIC VALUE; GENE AMPLIFICATION; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC MARKER; GENOTYPE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MOLECULAR CLONING; ONCOGENE K RAS; POINT MUTATION; PRIORITY JOURNAL; PROGNOSIS; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 5; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DNA PRIMERS; GENES, APC; GENES, DCC; GENETIC HETEROGENEITY; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS P21(RAS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53; VARIATION (GENETICS);

EID: 0035426926     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1343     Document Type: Article

References (49)

1. Presence of ras gene mutations in human colorectal cancers
2. Identification of FAP locus genes from chromosome 5q21
3. Identification of a chromosome 18q gene that is altered in colorectal cancers
4. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
5. Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas
6. A genetic model for colorectal tumorigenesis
7. Molecular interactions in the Vogelstein model of colorectal carcinoma
8. Lessons from hereditary colorectal cancer
9. Intratumor cellular heterogeneity and alterations in ras oncogene and p53 tumor suppressor gene in human prostate carcinoma
10. Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer
11. ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer
12. Clonal heterogeneity in human esophageal squamous cell carcinomas on DNA analysis
13. Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers
14. Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas
15. Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas
16. Genetic diversity at the p53 locus between primary human colorectal adenomas and their lymph-node metastases
17. Comparison of phenotypic and genotypic features in human primary large bowel carcinomas and lymph node metastases
18. Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression
19. Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality
20. Heterogeneity of colorectal adenocarcinomas evaluated by flow cytometry and histopathology
21. Analysis of subclonal expansion of colorectal carcinomas by flow cytometry
22. Intratumoral heterogeneity in colorectal carcinoma: Trucut sampling for DNA ploidy analysis
23. Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon
24. p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer
25. Association of p53 mutations with short survival in colorectal cancer
26. Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas
27. Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer
28. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer
29. Current status of adjuvant chemotherapy for colorectal cancer. Can molecular markers play a role in predicting prognosis?
30. Histological typing of intestinal tumours
31. Microdissection by exclusion and DNA extraction for multiple PCR analyses from archival tissue sections
32. A frequent alteration of p53 gene in carcinoma in adenoma of colon
33. An improved method for rapid screening of DNA mutations by non-radioactive single-strand conformation polymorphism procedure
34. Allelotype of colorectal carcinomas
35. Genetic instabilities in human cancers
36. Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability
37. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
38. Short telomeres on human chromosome 17p
39. Regulation and regulatory activities of centrosomes
40. Genomic instability: First step to carcinogenesis
41. DNA methylation and chromosome instability in breast cancer cell lines
42. Intratumor heterogeneity of chromosome 1, 7, 17, and 18 aneusomies obtained by FISH and association with flow cytometric DNA index in human colorectal adenocarcinomas
43. Alteration of p53 clonality accompanying colorectal cancer progression
44. K-ras point mutations in human colorectal carcinomas: Relation to aneuploidy and metastasis
45. Flow cytometric analysis of the DNA content in primary and metastatic lesions of colorectal cancer
46. Kirsten ras mutations in patients with colorectal cancer: The multi-center "RASCAL" study
47. The type of K-ras mutation determines prognosis in colorectal cancer
48. Colorectal carcinoma. DNA ploidy pattern and prognosis with reference to tumor DNA heterogeneity