Expression of alternatively spliced Lck transcripts from the proximal promoter in colorectal cancer derived cell lines

Anticancer Research

Volumn 16, Issue 4 A, 1996, Pages 1733-1737

  Mayer, Karin ^a   Ballhausen, Wolfgang G ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Alternative splicing; Colorectal cancer; lck protooncogene; T cell

Indexed keywords

MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL DIFFERENTIATION; COLORECTAL CANCER; CONTROLLED STUDY; DNA SEQUENCE; EPITHELIUM TUMOR; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOID CELL; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSCRIPTION; T LYMPHOCYTE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; B-LYMPHOCYTES; BASE SEQUENCE; CELL LINE; COLORECTAL NEOPLASMS; DNA PRIMERS; DNA, NEOPLASM; EXONS; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SRC-FAMILY KINASES; TRANSCRIPTION, GENETIC;

EID: 0029766159     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Bolen JB: Nonreceptor protein tyrosine kinases. Oncogene 8: 2025-2031, 1993.
2. Perlmutter RM, Marth JD, Lewis DB, Peet R, Ziegler SF and Wilson CB: Structure and expression of lck transcript in human lymphoid cells. J Cell Biochem 38: 117-126, 1988.
3. lck in T cell signalling and thymocyte development. Adv Immunol 56; 151-178, 1994.
4. Anderson SJ and Perlmutter RM: A signalling pathway governing early thymocyte maturation. Immunol Today 16: 99-105, 1995.
5. Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y and Mak TW: A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases. Eur J Immunol 16: 1643-1646, 1986.
6. Sartor O, Gregory FS, Smyth-Templeton N, Pawar S, Perlmutter RM and Rosen N: Selective expression of alternative lck mRNAs in human malignant cell lines. Mol Cell Biol 9: 2983-2988, 1989.
7. lck kinase expression and control of DNA synthesis in activated human B lymphocytes. J Biol Chem 268: 8169-8171, 1993.
8. Veillette A, Foss FM, Sausville EA, Bolen JB and Rosen N: Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res 1: 357-374, 1987.
9. Marth JD, Peet R, Krebs EG and Perlmutter RM: A lymphocytespecific protein-tyrosine kinase is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 43: 393-404, 1985.
10. Adler HT, Reynolds PJ, Kelley CM and Sefton BM: Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters. J Virol 62: 4113-4122, 1988.
11. Burnett RC, David J-C, Harden AM, Le Beau MM, Rowley JD and Diaz MO: The LCK gene is involved in the t(1:7)(p34:q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2. Genes Chromos Cancer 3: 461-467, 1991.
12. Wright DD, Scfton BM and Kamps MP: Oncogenic activation of the lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Mol Cell Biol 14: 2429-2437, 1994.
13. lck, reveals its oncogenic potential in fibroblasts. Proc Natl Acad Sci USA 85: 4247-4251, 1988.
14. lck). Mol Cell Biol 8: 540-550, 1988.
15. Mayer KM, Ansotegui IJ and Ballhausen WG: The human lck cDNA clone YT16 is a transforming oncogene. Anticancer Res 12: 485-488, 1992.
16. Takadera T, Leung S, Gernone A, Koga Y, Takihara Y, Miyamoto NG and Mak TW: Structure of the two promoters of the human lck gene: Differential accumulation of two classes of lck transcripts in T cells. Mol Cell Biol 9: 2173-2180, 1989.
17. Wildin RS, Garvin AM, Pawar S, Lewis DB, Abraham KM, Forbush KA, Ziegler SF, Allen JM and Perlmutter RM: Developmental regulation of lck gene expression in T lymphocytes. J Exp Med 173: 383-393, 1991.
18. Voronova AF, Adler HT and Sefton BM: Two lck transcripts containing different 5' untranslated regions are present in T-cells. Mol Cell Biol 7: 4407-4413, 1987.
19. Reynolds PJ, Lesley J, Trotter J, Schulte R, Hyman R and Sefton B: Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development. Mol Cell Biol 10: 4266-4270, 1990.
20. lck in metastatic colorectal cancer cells. Int J Oncol 3: 369-373, 1993.
21. Leung S and Miyamoto NG: Differential expression of two classes of lck: transcripts upon phorbol ester treatment of human leukemic T cells. J Cell Physiol 148: 344-352, 1991.
22. Rouer E, Dreyfus F, Melle J and Benarous R: Pattern of expression of five alternative transcripts of the lck gene in different hematopoetic malignancies: Correlation of the level of lck messenger RNA IB with the immature phenotype of the malignancy. Cell Growth Differentiation 5: 659-666, 1994.
23. Marth JD, Overell RW, Meier KE, Krebs EG and Perlmutter RM: Translational activation of the lck proto-oncogene. Nature 332: 171-173, 1988.
24. lck during myeloid differentiation of LSTRA cells. Cell Growth Differentiation 5: 1215-1223, 1944.
25. Resh MD: Myristylation and palmitylation of src family members: The fats of the matter. Cell 76: 411-413, 1994.
26. Yurchak LK and Sefton BM: Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase. Mol Cell Biol 15: 6914-6922, 1995.