Src tyrosine kinases mediate crystalline silica-induced NF-κB activation through tyrosine phosphorylation of IκB-α and p65 NF-κB in rAW 264.7 macrophages

Toxicological Sciences

Volumn 90, Issue 2, 2006, Pages 470-477

  Kang, Jihee Lee ^a   Jung, Hae J ^a   Lee, Kyungeun ^a   Kim, Hyung R ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Crystalline silica; Mitogen activated protein kinases; NF B; RAW 264.7 macrophages; Src tyrosine kinases

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; DAMNACANTHAL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; SILICON DIOXIDE; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOTAGMIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; ONCOGENE SRC; PERITONEUM MACROPHAGE; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTHRAQUINONES; CELL LINE; ENZYME INHIBITORS; I-KAPPA B PROTEINS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PYRAZOLES; PYRIMIDINES; SILICON DIOXIDE; TRANSCRIPTION FACTOR RELA; TYROSINE;

ANIMALIA;

EID: 33645129200     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj096     Document Type: Article

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