Phosphoinositide 3-kinase activity leads to silica-induced NF-ΚB activation through interacting with tyrosine-phosphorylated IΚB-α and contributing to tyrosine phosphorylation of p65 NF-ΚB

Molecular and Cellular Biochemistry

Volumn 248, Issue 1-2, 2003, Pages 17-24

  Kang, Jihee Lee ^a   Lee, Hui Su ^a   Pack, In Soon ^a   Hur, Kyu Chung ^b   Castranova, Vincent ^c  

^a Ewha Womans University School of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

NF B; PI3 kinase; RAW 264.7 cells; Reactive oxygen species; Silica

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; ANTIOXIDANT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PERVANADATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P85; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; SUPEROXIDE DISMUTASE; SYNAPTOTAGMIN; TYROSINE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; DATA ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SILICOSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACETYLCYSTEINE; ANDROSTADIENES; ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; EIF-2 KINASE; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MICE; MODELS, BIOLOGICAL; NF-KAPPA B; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PYRROLIDINES; REACTIVE OXYGEN SPECIES; SILICON DIOXIDE; SUPEROXIDE DISMUTASE; THIOCARBAMATES; TIME FACTORS; TYROSINE;

ANIMALIA;

EID: 0037966408     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024163630166     Document Type: Article

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