A genetic screen targeting the tumor necrosis factor/eiger signaling pathway: Identification of drosophila TAB2 as a functionally conserved component

Genetics

Volumn 171, Issue 4, 2005, Pages 1683-1694

  Geuking, Peter ^a   Narasimamurthy, Rajesh ^a   Basler, Konrad ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DROSOPHILA PROTEIN; PHOSPHOTRANSFERASE; PROTEIN EIGER; PROTEIN TAB2; PROTEIN TAB3; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE KINASE KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME MECHANISM; FEMALE; GENE ISOLATION; GENE MAPPING; GENE REPRESSION; GENE TARGETING; GENETIC CONSERVATION; GENETIC EPISTASIS; GENETIC SCREENING; GENOME ANALYSIS; MALE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; DROSOPHILA; DROSOPHILA PROTEINS; GENETIC SCREENING; GENETIC VECTORS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUCIFERASES; MAP KINASE KINASE KINASES; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHENOTYPE; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC; TNF RECEPTOR-ASSOCIATED FACTOR 1;

MAMMALIA;

EID: 33645127265     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.105.045534     Document Type: Article

References (39)

1. ADACHI-YAMADA, T., K. FUJIMURA-KAMADA, Y. NISHIDA and K. MATSUMOTO, 1999 Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature 400: 166-169.
2. ASHBURNER, M., 1989 Drosophila. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. BASLER, K., and G. STRUHL, 1994 Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368: 208-214.
4. BOUTROS, M., H. AGAISSE and N. PERRIMON, 2002 Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev. Cell 3: 711-722.
5. BRADLEY, P. L., and D. J. ANDREW, 2001 ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster. Development 128: 3001-3015.
6. BRAND, A. H., and N. PERRIMON, 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
7. BROGIOLO, W., H. STOCKER, T. IKEYA, F. RINTELEN, R. FERNANDEZ et al., 2001 An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11: 213-221.
8. CHA, G. H., K. S. CHO, J.H. LEE, M. KIM, E. KIM et al., 2003 Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol. Cell. Biol. 23: 7982-7991.
9. CHEUNG, P. C., A. R. NEBREDA and P. COHEN, 2004 TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 378: 27-34.
10. CLEMENS, J. C., C. A. WORBY, N. SIMONSON-LEFF, M. MUDA, T. MAEHAMA et al., 2000 Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad. Sci. USA 97: 6499-6503.
11. FU, C. A., M. SHEN, B. C. HUANG, J. LASAGA, D. G. PAYAN et al., 1999 TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. J. Biol. Chem. 274: 30729-30737.
12. HAY, B. A., T. WOLFF and G. M. RUBIN, 1994 Expression of baculovirus P35 prevents cell death in Drosophila. Development 120: 2121-2129.
13. IGAKI, T., H. KANDA, Y. YAMAMOTO-GOTO, H. KANUKA, E. KURANAGA et al., 2002 Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 21: 3009-3018.
14. ISHITANI, T., G. TAKAESU, J. NINOMIYA-TSUJI, H. SHIBUYA, R. B. GAYNOR et al., 2003 Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 22: 6277-6288.
15. JIN, G., A. KLIKA, M. CALLAHAN, B. FAGA, J. DANZIG et al., 2004 Identification of a human NF-kappaB-activating protein, TAB3. Proc. Natl. Acad. Sci. USA 101: 2028-2033.
16. KANAYAMA, A., R. B. SETH, L. SUN, C. K. EA, M. HONG et al., 2004 TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol. Cell 15: 535-548.
17. KANDA, H., T. IGAKI, H. KANUKA, T. YAGI and M. MIURA, 2002 Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J. Biol. Chem. 277: 28372-28375.
18. KAUPPILA, S., W. S. MAATY, P. CHEN, R. S. TOMAR, M. T. EBY et al., 2003 Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene 22: 4860-4867.
19. KISHIMOTO, K., K. MATSUMOTO and J. NINOMIYA-TSUJI, 2000 TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem. 275: 7359-7364.
20. LIU, H., Y. C. SU, E. BECKER, J. TREISMAN and E. Y. SKOLNIK, 1999 A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Curr. Biol. 9: 101-104.
21. LOCKSLEY, R. M., N. KILLEEN and M. J. LENARDO, 2001 The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104: 487-501.
22. MARTIN-BLANCO, E., A. GAMPEL, J. RING, K. VIRDEE, N. KIROV et al., 1998 puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 12: 557-570.
23. MORENO, E., M. YAN and K. BASLER, 2002 Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr. Biol. 12: 1263-1268.
24. NEWSOME, T. P., B. ASLING and B. J. DICKSON, 2000 Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127: 851-860.
25. NINOMIYA-TSUJI, J., K. KISHIMOTO, A. HIYAMA, J. INOUE, Z. CAO et al., 1999 The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-256.
26. PARKS, A. L., K. R. COOK, M. BELVIN, N. A. DOMPE, R. FAWCETT et al., 2004 Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat. Genet. 36: 288-292.
27. RIESGO-ESCOVAR, J. R., M. JENNI, A. FRITZ and E. HAFEN, 1996 The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10: 2759-2768.
28. SAKURAI, H., H. MIYOSHI, J. MIZUKAMI and T. SUGITA, 2000 Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. FEBS Lett. 474: 141-145.
29. SHEN, B., H. LIU, E. Y. SKOLNIK and J. L. MANLEY, 2001 Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proc. Natl. Acad. Sci. USA 98: 8596-8601.
30. SHI, C. S., and J. H. KEHRL, 2003 Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J. Biol. Chem. 278: 15429-15434.
31. SHI, C. S., A. LEONARDI, J. KYRIAKIS, U. SIEBENLIST and J. H. KEHRL, 1999 TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. J. Immunol. 163: 3279-3285.
32. SHIBUYA, H., K. YAMAGUCHI, K. SHIRAKABE, A. TONEGAWA, Y. GOTOH et al., 1996 TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272: 1179-1182.
33. SLUSS, H. K., Z. HAN, T. BARRETT, R. J. DAVIS and Y. T. IP, 1996 A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10: 2745-2758.
34. STRONACH, B., 2005 Dissecting JNK signaling, one KKKinase at a time. Dev. Dyn. 232: 575-584.
35. STRONACH, B., and N. PERRIMON, 2002 Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 16: 377-387.
36. TAKAESU, G., S. KISHIDA, A. HIYAMA, K. YAMAGUCHI, H. SHIBUYA et al., 2000 TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5: 649-658.
37. VIDAL, S., R. S. KHUSH, F. LEULIER, P. TZOU, M. NAKAMURA et al., 2001 Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev. 15: 1900-1912.
38. WALLACH, D., E. E. VARFOLOMEEV, N. L. MALININ, Y. V. GOLTSEV, A. V. KOVALENKO et al., 1999 Tumor necrosis factor receptor and Fas signaling mechanisms. Annu. Rev. Immunol. 17: 331-367.
39. YUASA, T., S. OHNO, J. H. KEHRL and J. M. KYRIAKIS, 1998 Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J. Biol. Chem. 273: 22681-22692.