Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

Genes and Development

Volumn 16, Issue 3, 2002, Pages 377-387

  Stronach, Beth ^a   Perrimon, Norbert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Dorsal closure; JNK; Kinase; Morphogenesis

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN SLIPPER; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FATE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; GENOME; MALE; MORPHOGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL POLARITY; CLONING, MOLECULAR; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; MAP KINASE KINASE 7; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; MUTATION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ANIMALIA; HEXAPODA; MAMMALIA;

EID: 0036468006     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.953002     Document Type: Article

References (64)

1. The genome sequence of Drosophila melanogaster
2. Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation
3. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
4. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
5. Mammalian MAP kinase signalling cascades
6. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
7. The Ste20 group kinases as regulators of MAP kinase cascades
8. Signal transduction by the JNK group of MAP kinases
9. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains
10. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2
11. The FlyBase database of the Drosophila genome projects and community literature
12. Identification and characterization of SPRK, a novel src-homology 3 domain-containing prolinerich kinase with serine/threonine kinase activity
13. MEKK2 gene disruption causes loss of cytokine production in esponse to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
14. Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis
15. Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
16. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
17. A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila
18. Participation of small GTPases in dorsal closure of the Drosophila embryo: Distinct roles for Rho subfamily proteins in epithelial morphogenesis
19. The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion
20. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
21. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous
22. Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement
23. MLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain
24. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
25. AP-1 in mouse development and tumorigenesis
26. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain
27. Drosophila morphogenesis: Movements behind the edge
28. Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways
29. Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways
30. Dimerization via tandem leucine zippers is essential for the activation of the mitogenactivated protein kinase kinase kinase, MLK-3
31. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
32. Puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
33. The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate
34. The role of the Drosophila TAK homologue dTAK during development
35. Planar polarity in the Drosophila eye: A multifaceted view of signaling specificity and cross-talk
36. Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes
37. JNK signaling and morphogenesis in Drosophila
38. The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling
39. Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
40. Characterization and cloning of fasciclin III: A glycoprotein expressed on a subset of neurons and axon pathways in Drosophila
41. Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome
42. The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1
43. Dcdc42 acts in TGF-β signaling during Drosophila morphogenesis: Distinct roles for the Drac1/JNK and Dcdc42/TGF-β cascades in cytoskeletal regulation
44. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
45. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
46. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
47. A Drosophila complementary DNA resource
48. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
49. Stress signaling in Drosophila
50. Two muscle-specific LIM proteins in Drosophila
51. The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway
52. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development
53. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family
54. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
55. JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye
56. Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylation of Thr258 of murine mitogen-activated protein kinase kinase 4
57. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of re1/NF-κB-dependent innate immune responses
58. Jun, the oncoprotein
59. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye
60. Mekk3 is essential for early embryonic cardiovascular development
61. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
62. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2- terminal kinase regulation but does not cause a measurable defect in NF-κ B activation
63. Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants