A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye

Genetics

Volumn 171, Issue 4, 2005, Pages 1655-1672

  Anderson, Jason ^a   Bhandari, Rohan ^a   Kumar, Justin P ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DROSOPHILA PROTEIN; MUTANT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CREB; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EYE DEVELOPMENT; FEMALE; GENE INTERACTION; GENE MUTATION; GENE TARGETING; GENETIC SCREENING; MALE; NONHUMAN; PHENOTYPE; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN VARIANT; RETINA DEVELOPMENT;

ANIMALS; CREB-BINDING PROTEIN; CROSSES, GENETIC; DROSOPHILA; DROSOPHILA PROTEINS; GENE COMPONENTS; GENETIC SCREENING; MICROSCOPY, ELECTRON, SCANNING; PHENOTYPE; PHOTORECEPTORS, INVERTEBRATE;

DROSOPHILA MELANOGASTER;

EID: 33645123020     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.105.045450     Document Type: Article

References (116)

1. ABRELL, S., P. CARRERA and H. JACKLE, 2000 A modifier screen of ectopic Kruppel activity identifies autosomal Drosophila chromosomal sites and genes required for normal eye development. Chromosoma 109: 334-342.
2. AKAM, M. E., A. MARTINEZ-ARIAS, R. WEINZIERL and C. D. WILDE, 1985 Function and expression of ultrabithorax in the Drosophila embryo. Cold Spring Harbor Symp. Quant. Biol. 50: 195-200.
3. AKIMARU, H., Y. CHEN, P. DAI, D. X. HOU, M. NONAKA et al., 1997a Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386: 735-738.
4. AKIMARU, H., D. X. HOU and S. ISHII, 1997b Drosophila CBP is required for dorsal-dependent twist gene expression. Nat. Genet. 17: 211-214.
5. ANDREW, D. J., A. BAIG, P. BHANOT, S. M. SMOLIK and K. D. HENDERSON, 1997 The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle. Development 124: 181-193.
6. ARANY, Z., W. R. SELLERS, D. M. LIVINGSTON and R. ECKNER, 1994 E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77: 799-800.
7. ASHE, H. L., M. MANNERVIK and M. LEVINE, 2000 Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo. Development 127: 3305-3312.
8. AVANTAGGIATI, M. L., V. OGRYZKO, K. GARDNER, A. GIORDANO, A. S. LEVINE et al., 1997 Recruitment of p300/CBP in p530- dependent signal pathways. Cell 89: 1175-1184.
9. BAKER, N. E., S. YU and D. HAN, 1996 Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr. Biol. 6: 1290-1301.
10. BANNISTER, A. J., and T. KOUZARIDES, 1996 The CBP co-activator is a histone acetyltransferase. Nature 384: 641-643.
11. BANTIGNIES, F., R. H. GOODMAN and S. M. SMOLIK, 2000 Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol. Cell. Biol. 20: 9317-9330.
12. BASLER, K., P. SIEGRIST and E. HAFEN, 1989 The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements. EMBO J. 8: 2381-2386.
13. BELVIN, M. P., H. ZHOU and J. C. YIN, 1999 The Drosophila dCREB2 gene affects the circadian clock. Neuron 22: 777-787.
14. BERGERET, E., I. PIGNOT-PAINTRAND, A. GUICHARD, K. RAYMOND, M. O. FAUVARQUE et al., 2001 RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster. Mol. Cell. Biol. 21: 6280-6291.
15. BIEHS, B., V. FRANCOIS and E. BIER, 1996 The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev. 10: 2922-2934.
16. BOWTELL, D. D., B. E. KIMMEL, M. A. SIMON and G. M. RUBIN, 1989 Regulation of the complex pattern of sevenless expression in the developing Drosophila eye. Proc. Natl. Acad. Sci. USA 86: 6245-6249.
17. CADIGAN, K. M., and R. NUSSE, 1996 wingless signaling in the Drosophila eye and embryonic epidermis. Development 122: 2801-2812.
18. CAGAN, R. L., and D. F. READY, 1989 The emergence of order in the Drosophila pupal retina. Dev. Biol. 136: 346-362.
19. CHAKRAVARTI, D., V. J. LAMORTE, M. C. NELSON, T. NAKAJIMA, I. G. SCHULMAN et al., 1996 Role of CBP/P300 in nuclear receptor signalling. Nature 383: 99-103.
20. CHAN, H. M., and N. B. LA THANGUE, 2001 p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 114: 2363-2373.
21. CHOI, J. S., J. A. KIM and C. K. JOO, 2003 Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve. Invest. Ophthalmol. Vis. Sci. 44: 1747-1752.
22. CHRIVIA, J. C., R. P. KWOK, N. LAMB, M. HAGIWARA, M. R. MONTMINY et al., 1993 Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855-859.
23. COUPRY, I., C. ROUDAUT, M. STEF, M. A. DELRUE, M. MARCHE et al., 2002 Molecular analysis of the CBP gene in 60 patients with Rubinstein-Taybi syndrome. J. Med. Genet. 39: 415-421.
24. DECOTTO, E., and E. L. FERGUSON, 2001 A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo. Development 128: 3831-3841.
25. DENG, Z., C. J. CHEN, M. CHAMBERLIN, F. LU, G. A. BLOBEL et al., 2003 The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activation. Mol. Cell. Biol. 23: 2633-2644.
26. DICKSON, B., and E. HAFEN, 1993 Genetic dissection of eye development in Drosophila, pp. 1327-1361 in The Development of Drosophila melanogaster, edited by M. BATE and A. MARTINEZ ARIAS. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. DOKUCU,M. E., S. L. ZIPURSKY and R. L. CAGAN, 1996 Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina. Development 122: 4139-4147.
28. EBERL, D. F., and A. J. HILLIKER, 1988 Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster. Genetics 118: 109-120.
29. FLORENCE, B., and W. MCGINNIS, 1998 A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function. Genetics 150: 1497-1511.
30. FOSSETT, N., K. HYMAN, K. GAJEWSKI, S. H. ORKIN and R. A. SCHULZ, 2003 Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proc. Natl. Acad. Sci. USA 100: 11451-11456.
31. FRANCOIS, V., M. SOLLOWAY, J. W. O'NEILL, J. EMERY and E. BIER, 1994 Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 8: 2602-2616.
32. FRODIN, M., and GAMMELTOFT, S., 1999 Role and regulation of 90kDa ribosomal S6 kinase (RSK) in signal transduction. Mol. Cell. Endocrinol. 151: 65-77.
33. FREEMAN, M., 1996 Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660.
34. FREEMAN, M., B. E. KIMMEL and G. M. RUBIN, 1992 Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development. Development 116: 335-346.
35. GOLDMAN, P. S., V. K. TRAN and R. H. GOODMAN, 1997 The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog. Horm. Res. 52: 103-120.
36. GOODMAN, R. H., and S. SMOLIK, 2000 CBP/p300 in cell growth, transformation, and development. Genes Dev. 14: 1553-1577.
37. GU, W., X. L. SHI and R. G. ROEDER, 1997 Synergistic activation of transcription by CBP and p53. Nature 387: 819-823.
38. GUION-ALMEIDA, M. L., and A. RICHIERI-COSTA, 1992 Callosal agenesis, iris coloboma, and megacolon in a Brazilian boy with Rubinstein-Taybi syndrome. Am. J. Med. Genet. 43: 929-931.
39. HAWKINS, N. C., J. THORPE and T. SCHÜPBACH, 1996 Encore, a gene required for the regulation of germ line mitosis and oocyte differentiation during Drosophila oogenesis. Development 122: 281-290.
40. HAY, B. A., D. A. WASSARMAN and G. M. RUBIN, 1995 Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83: 1253-1262.
41. HEBERLEIN, U., and K. MOSES, 1995 Mechanisms of Drosophila retinal morphogenesis: the virtues of being progressive. Cell 81: 987-990.
42. IKEDA, K., Y. WATANABE, H. OHTO and K. KAWAKAMI, 2002 Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol. Cell. Biol. 22: 6759-6766.
43. JANG, C. C., J. L. CHAO, N. JONES, L. C. YAO, D. A. BESSARAB et al., 2003 Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development. Development 130: 2939-2951.
44. JANKNECHT, R., 2002 The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol. Histopathol. 17: 657-668.
45. JARMAN, A. P., E. H. GRELL, L. ACKERMAN, L. Y. JAN and Y. N. JAN, 1994 atonal is the proneural gene for Drosophila photoreceptors. Nature 369: 398-400.
46. JARMAN, A. P., Y. SUN, L. Y. JAN and Y. N. JAN, 1995 Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121: 2019-2030.
47. KALKHOVEN, E., J. H. ROELFSEMA, H. TEUNISSEN, A. DEN BOER, Y. ARIYUREK et al., 2003 Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome. Hum. Mol. Genet. 12: 441-450.
48. KEE, B. L., J. ARIAS and M. R. MONTMINY, 1996 Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J. Biol. Chem. 271: 2373-2375.
49. KIMMEL, B. E., U. HEBERLEIN and G. M. RUBIN, 1990 The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev. 4: 712-727.
50. KRAMER, S., M. OKABE, N. HACOHEN, M. A. KRASNOW and Y. HIROMI, 1999 Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 126: 2515-2525.
51. KUMAR, J. P., 2001 Signalling pathways in Drosophila and vertebrate retinal development. Nat. Rev. Genet. 2: 846-857.
52. KUMAR, J. P., and K. MOSES, 1997 Transcription factors in eye development: A gorgeous mosaic? Genes Dev. 11: 2023-2028.
53. KUMAR, J. P., and K. MOSES, 2001 Eye specification in Drosophila: perspectives and implications. Semin. Cell Dev. Biol. 12: 469-474.
54. KUMAR, J. P., M. TIO, F. HSIUNG, S. AKOPYAN, L. GABAY et al., 1998 Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125: 3875-3885.
55. KUMAR, J. P., F. HSIUNG, M. A. POWERS and K. MOSES, 2003 Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye. Development 130: 3703-3714.
56. KUMAR, J. P., T. JAMAL, A. DOETSCH, F. R. TURNER and J. B. DUFFY, 2004 CREB binding protein functions during successive stages of eye development in Drosophila. Genetics 168: 877-893.
57. KWOK, R. P., J. R. LUNDBLAD, J. C. CHRIVIA, J. P. RICHARDS, H. P. BACHINGER et al., 1994 Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370: 223-226.
58. LAMPRECHT, R., 1999 CREB: a message to remember. Cell. Mol. Life Sci. 55: 554-563.
59. LEE, J. R., S. URBAN, C. F. GARVEY and M. FREEMAN, 2001 Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell 107: 161-171.
60. LEVY, N. S., 1976 Juvenile glaucoma in the Rubinstein-Taybi syndrome. J. Pediatr. Ophthalmol. 13: 141-143.
61. LILJA, T., D. QI, M. STABELL and M. MANNERVIK, 2003 The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo. Dev. Biol. 262: 294-302.
62. LUDLAM, W. H., M. H. TAYLOR, K. G. TANNER, J. M. DENU, R. H. GOODMAN et al., 2002 The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster. Mol. Cell. Biol. 22: 3832-3841.
63. LUNDE, K., B. BIEHS, U. NAUBER and E. BIER, 1998 The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development 125: 4145-4154.
64. LUNDE, K., J. L. TRIMBLE, A. GUICHARD, K. A. GUSS, U. NAUBER et al., 2003 Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development 130: 235-248.
65. MANNERVIK, M., Y. NIBU, H. ZHANG and M. LEVINE, 1999 Transcriptional coregulators in development. Science 284: 606-609.
66. MAREK, K. W., N. NG, R. FETTER, S. SMOLIK, C. S. GOODMAN et al., 2000 A genetic analysis of synaptic development: pre- and postsynaptic dCBP control transmitter release at the Drosophila NMJ. Neuron 25: 537-547.
67. MARTIN-BLANCO, E., F. ROCH, E. NOLL, A. BAONZA, J. B. DUFFY et al., 1999 A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development 126: 5739-5747.
68. MARTINEZ-BALBAS, M. A., A. J. BANNISTER, K. MARTIN, P. HAUS-SEUFFERT, M. MEISTERERNST et al., 1998 The acetyltransferase activity of CBP stimulates transcription. EMBO J. 17: 2886-2893.
69. MCMANUS, K. J., and M. J. HENDZEL, 2001 CBP, a transcriptional coactivator and acetyltransferase. Biochem. Cell Biol. 79: 253-266.
70. MOSES, K., and G. M. RUBIN, 1991 Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev. 5: 583-593.
71. MOSES, K., M. C. ELLIS and G. M. RUBIN, 1989 The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells. Nature 340: 531-536.
72. MURATA, T., R. KUROKAWA, A. KRONES, K. TATSUMI, M. ISHII et al., 2001 Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome. Hum. Mol. Genet. 10: 1071-1076.
73. NEWFELD, S. J., and N. T. TAKAESU, 2002 An analysis using the hobo genetic system reveals that combinatorial signaling by the Dpp and Wg pathways regulates dpp expression in leading edge cells of the dorsal ectoderm in Drosophila melanogaster. Genetics 161: 685-692.
74. NORDHEIM, A., 1994 Transcription factors. CREB takes CBP to tango. Nature 370: 177-178.
75. OIKE, Y., A. HATA, T. MAMIYA, T. KANAME, Y. NODA et al., 1999 Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominantnegative mechanism. Hum. Mol. Genet. 8: 387-396.
76. PERCIVAL-SMITH, A., J. WEBER, E. GILFOYLE and P. WILSON, 1997 Genetic characterization of the role of the two HOX proteins, Proboscipedia and Sex Combs Reduced, in determination of adult antennal, tarsal, maxillary palp and proboscis identities in Drosophila melanogaster. Development 124: 5049-5062.
77. PETRIJ, F., R. H. GILES, H. G. DAUWERSE, J. J. SARIS, R. C. HENNEKAM et al., 1995 Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376: 348-351.
78. PETRUK, S., Y. SEDKOV, S. SMITH, S. TILLIB, V. KRAEVSKI et al., 2001 Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science 294: 1331-1334.
79. RAMAKRISHNAN, S., D. C. SHARMA, V. RAMAKRISHNAN, P. S. PARIHAR, S. SHARMA et al., 1990 Rubinstein-Taybi syndrome. Indian Pediatr. 27: 404-405.
80. READY, D. F., 1989 A multifaceted approach to neural development. Trends Neurosci. 12: 102-110.
81. READY, D. F., T. E. HANSON and S. BENZER, 1976 Development of the Drosophila retina, a neurocrystalline lattice. Dev. Biol. 53: 217-240.
82. REUTER, R., 1994 The gene serpent has homeotic properties and specifies endoderm versus ectoderm within the Drosophila gut. Development 120: 1123-1135.
83. ROSE, R. E., N. M. GALLAHER, D. J. ANDREW, R. H. GOODMAN and S. M. SMOLIK, 1997 The CRE-binding protein dCREB-A is required for Drosophila embryonic development. Genetics 146: 595-606.
84. ROY, F. H., R. L. SUMMITT, R. L. HIATT and J. G. HUGHES, 1968 Ocular manifestations of the Rubinstein-Taybi syndrome. Case report and review of the literature. Arch. Ophthalmol. 79: 272-278.
85. RUTLEDGE, B. J., K. ZHANG, E. BIER, Y. N. JAN and N. PERRIMON, 1992 The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev. 6: 1503-1517.
86. SAKAI, T., and Y. KIDOKORO, 2002 Overexpression of a CREB repressor isoform enhances the female sexual receptivity in Drosophila. Behav. Genet. 32: 413-422.
87. SCHÜPBACH, T., and E. WIESCHAUS, 1989 Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Genetics 121: 101-117.
88. SHI, Y., and C. MELLO, 1998 A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 12: 943-955.
89. SILENGO, M. C., M. LERONE, A. PELIZZA, R. GATTI, A. BARABINO et al., 1990 A new syndrome with cerebro-oculo-skeletal-renal involvement. Pediatr. Radiol. 20: 612-614.
90. SMOLIK, S. M., R. E. ROSE and R. H. GOODMAN, 1992 A cyclic AMP-responsive element-binding transcriptional activator in Drosophila melanogaster, dCREB-A, is a member of the leucine zipper family. Mol. Cell. Biol. 12: 4123-4131.
91. SONG, Z., and H. STELLER, 1999 Death by design: mechanism and control of apoptosis. Trends Cell Biol. 9: M49-M52.
92. SONG, Z., B. GUAN, A. BERGMAN, D. W. NICHOLSON, N. A. THORNBERRY et al., 2000 Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim. Mol. Cell. Biol. 20: 2907-2914.
93. TAKAESU, N. T., A. N. JOHNSON, O. H. SULTANI and S. J. NEWFELD, 2002 Combinatorial signaling by an unconventional Wg pathway and the Dpp pathway requires Nejire (CBP/p300) to regulate dpp expression in posterior tracheal branches. Dev. Biol. 247: 225-236.
94. TANAKA, Y., I. NARUSE, T. MAEKAWA, H. MASUYA, T. SHIROISHI et al., 1997 Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc. Natl. Acad. Sci. USA 94: 10215-10220.
95. TAYLOR, J. P., A. A. TAYE, C. CAMPBELL, P. KAZEMI-ESFARJANI, K. H. FISCHBECK et al., 2003 Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev. 17: 1463-1468.
96. TOMLINSON, A., and D. F. READY, 1987a Cell fate in the Drosophila ommatidium. Dev. Biol. 123: 264-275.
97. TOMLINSON, A., and D. F. READY, 1987b Neuronal differentiation in the Drosophila ommatidium. Dev. Biol. 120: 366-376.
98. TOMLINSON, A., B. E. KIMMEL and G. M. RUBIN, 1988 rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye. Cell 55: 771-784.
99. TREISMAN, J. E., and U. HEBERLEIN, 1998 Eye development in Drosophila: formation of the eye field and control of differentiation. Curr. Top. Dev. Biol. 39: 119-157.
100. URBAN, S., J. R. LEE and M. FREEMAN, 2001 Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107: 173-182.
101. URBAN, S., J. R. LEE and M. FREEMAN, 2002 A family of Rhomboid intramembrane proteases activates all Drosophila membranetethered EGF ligands. EMBO J. 21: 4277-4286.
102. USUI, T., S. M. SMOLIK and R. H. GOODMAN, 1993 Isolation of Drosophila CREB-B: a novel CRE-binding protein. DNA Cell Biol. 12: 589-595.
103. VAN BUSKIRK, C., N. C. HAWKINS and T. SCHÜPBACH, 2000 Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis. Development 127: 4753-4762.
104. VAN GENDEREN, M. M.,G. F. KINDS, F. C. RIEMSLAG and R. C. HENNEKAM, 2000 Ocular features in Rubinstein-Taybi syndrome: investigation of 24 patients and review of the literature. Br. J. Ophthalmol. 84: 1177-1184.
105. VOAS, M. G., and I. REBAY, 2004 Signal integration during development: insights from the Drosophila eye. Dev. Dyn. 229: 162-175.
106. WALTZER, L., and M. BIENZ, 1998 Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395: 521-525.
107. WALTZER, L., and M. BIENZ, 1999 A function of CBP as a transcriptional co-activator during Dpp signalling. EMBO J. 18: 1630-1641.
108. WALTZER, L., G. FERJOUX, L. BATAILLE and M. HAENLIN, 2003 Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis. EMBO J. 22: 6516-6525.
109. WING, J., L. ZHOU, L. SCHWARTZ and J. NAMBU, 1999 Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes. Cell Death Differ. 6: 212-213.
110. WITTWER, F., A. VAN DER STRATEN, K. KELEMAN, B. J. DICKSON AND E. HAFEN, 2001 Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Development 128: 791-800.
111. WOLFF, T., and D. F. READY, 1993 Pattern formation in the Drosophila retina, pp. 1277-1326 in The Development of Drosophila melanogaster, edited by M. BATE and A. MARTINEZ ARIAS. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
112. YIN, J. C., and T. TULLY, 1996 CREB and the formation of long-term memory. Curr. Opin. Neurobiol. 6: 264-268.
113. YIN, J. C., J. S. WALLACH, M. DEL VECCHIO, E. L. WILDER, H. ZHOU et al., 1994 Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79: 49-58.
114. YIN, J. C., M. DEL VECCHIO, H. ZHOU and T. TULLY, 1995a CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81: 107-115.
115. YIN, J. C., J. S. WALLACH, E. L. WILDER, J. KLINGENSMITH, D. DANG et al., 1995b A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinaseresponsive transcriptional activator and antagonist. Mol. Cell. Biol. 15: 5123-5130.
116. YU, K., M. A. STURTEVANT, B. BIEHS, V. FRANCOIS, R. W. PADGETT et al., 1996 The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. Development 122: 4033-4044.