Lilliputian: An AF4/FMR2-related protein that controls cell identity and cell growth

Development

Volumn 128, Issue 5, 2001, Pages 791-800

  Wittwer, F ^a   van der Straten, A ^a   Keleman, K ^a   Dickson, B J ^a   Hafen, E ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

AF4 FMR2; Cell size; Differentiation; Drosophila melanogaster; Lilliputian (lilli); PTEN

Indexed keywords

AF 4 PROTEIN; FMR 2 PROTEIN; LILLIPUTIAN PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL SIZE; CONTROLLED STUDY; DROSOPHILA; EYE; GENE MUTATION; MAMMAL; MENTAL DEFICIENCY; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN FAMILY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL DIFFERENTIATION; CELL NUCLEUS; CELL SIZE; DNA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; GENES, INSECT; GERM-LINE MUTATION; HUMANS; INSECT PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHENOTYPE; PHOSPHORIC MONOESTER HYDROLASES; PHOTORECEPTORS, INVERTEBRATE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0035097553     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Ligand-independent activation of the Sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye
2. Control of photoreceptor cell fate by the Sevenless protein requires a functional tyrosine kinase domain
3. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
4. Proteins regulating Ras and its relatives
5. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
6. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
7. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
8. Prediction of complete gene structures in human genomic DNA
9. A candidate gene for mild mental handicap at the FRAXE fragile site
10. Measuring dimensions, the regulation of size and shape
11. The multiple roles of PTEN in tumor suppression
12. The Sevenless signaling cassette mediates Drosophila EGF receptor function during epidermal development
13. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway
14. Mutations modulating Raf signaling in Drosophila eye development
15. Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
16. Multiple functions of the EGF receptor in Drosophila eye development
17. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation
18. Integration of positive and negative growth signals during ras pathway activation in vivo
19. Cell determination strategies in the Drosophila eye
20. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
21. Identification of the gene FMR2, associated with FRAXE mental retardation
22. Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators
23. Multiple Ras effector pathways contribute to G1 cell cycle progression
24. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
25. A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin
26. Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island
27. P element insertion-dependent gene activation in the Drosophila eye
28. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
29. Altered lymphoid development in mice deficient for the mAF4 proto-oncogene
30. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1
31. Ras promotes cell survival in Drosophila by downregulating hid expression
32. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
33. Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse
34. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias
35. Ras mutations in pediatric leukemias with MLL gene rearrangements
36. Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase
37. Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain
38. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila
39. Drosophila S6 kinase, a regulator of cell size
40. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
41. A genetic screen to identify components of the sina signaling pathway in Drosophila eye development
42. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
43. Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF- 4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia
44. Genetic control of size in Drosophila
45. Genetic and biochemical characterization of dTor, the Drosophila homolog of the target of rapamycin
46. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations
47. Ras1 promotes cellular growth in the Drosophila wing
48. The role of phosphoinositide 3-kinase lipid products in cell function
49. A genetic screen for novel components of the Ras/Mitogen-Activated Protein Kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein
50. The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure
51. Ras - A versatile cellular switch
52. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
53. Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian
54. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
55. P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster, isolation of lethals with different overgrowth phenotypes
56. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
57. The genetic control of organ growth, insights from Drosophila
58. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
59. Analysis of genetic mosaics in developing and adult Drosophila tissues