2-Deoxyglucose and NMDA inhibit protein synthesis in neurons and regulate phosphorylation of elongation factor-2 by distinct mechanisms

Journal of Neurochemistry

Volumn 96, Issue 3, 2006, Pages 815-824

  Maus, M ^a   Torrens, Y ^a   Gauchy, C ^a   Bretin, S ^a   Nairn, A C ^b   Glowinski, J ^a   Premont, J ^a,c  

^a INSERM   (France)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Centre Paul Faure   (France)

Author keywords

2 deoxyglucose; Cerebral cortex; Eukaryotic elongation factor 2; Neurons; NMDA; Protein synthesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; DEOXYGLUCOSE; DIZOCILPINE; ELONGATION FACTOR 2; ELONGATION FACTOR 2 KINASE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OLIGOMYCIN; PHOSPHOTRANSFERASE; PYRUVATE SODIUM; SODIUM AZIDE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN DAMAGE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; EUKARYOTE; MITOCHONDRIAL RESPIRATION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; ANTIMETABOLITES; BLOTTING, WESTERN; CALCIUM; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CELLS, CULTURED; CEREBRAL CORTEX; DEOXYGLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; IONOPHORES; LEUCINE; MICE; MODELS, BIOLOGICAL; N-METHYLASPARTATE; NEURONS; OLIGOMYCINS; PEPTIDE ELONGATION FACTOR 2; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN SYNTHESIS INHIBITORS; PYRUVIC ACID; SODIUM AZIDE; TIME FACTORS; TRITIUM;

EUKARYOTA;

EID: 33645104686     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03601.x     Document Type: Article

References (32)

1. Alirezaei M. Nairn AC. Glowinski J. Premont J. Marin P. 1999 Zinc inhibits protein synthesis in neurons. Potential role of phosphorylation of translation initiation factor-2α JBiolChem 274 32 433 32 438
2. Alirezaei M. Marin P. Nairn AC. Glowinski J. Premont J. 2001 Inhibition of protein synthesis in cortical neurons during exposure to hydrogen peroxide JNeurochem 76 1080 1088
3. Althausen S. Mengesdorf T. Mies G. Olah L. Nairn AC. Proud CG. Paschen W. 2001 Changes in the phosphorylation of initiation factor eIF-2α, elongation factor eEF-2 and p70, S6 kinase after transient focal cerebral ischaemia in mice JNeurochem 78 779 787
4. Ankarcrona M. Dypbukt JM. Bonfoco E. Zhivotovsky B. Orrenius S. Lipton SA. Nicotera P. 1995 Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function Neuron 15 961 973
5. Budd SL. Nicholls DG. 1996 Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells JNeurochem 67 2282 2291
6. Choi DW. Rothman SM. 1990 The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death AnnuRevNeurosci 13 171 182
7. Dyck JR. Kudo N. Barr AJ. Davies SP. Hardie DG. Lopaschuk GD. 1999 Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5′-AMP activated protein kinase EurJBiochem 262 184 190
8. el-Etr M. Cordier J. Glowinski J. Premont J. 1989 A neuroglial cooperativity is required for the potentiation by 2-chloroadenosine of the muscarinic-sensitive phospholipase C in the striatum JNeurosci 9 1473 1480
9. Greenberg ME. Hermanowski AL. Ziff EB. 1986 Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription MolCell Biol 6 1050 1057
10. Hardie DG. Scott JW. Pan DA. Hudson ER. 2003 Management of cellular energy by the AMP-activated protein kinase system FEBS Lett 546 113 120
11. Hata R. Maeda K. Hermann D. Mies G. Hossmann KA. 2000 Evolution of brain infarction after transient focal cerebral ischemia in mice JCerebBlood Flow Metab 20 937 946
12. Hermann DM. Kilic E. Hata R. Hossmann KA. Mies G. 2001 Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice Neuroscience 104 947 955
13. Horman S. Browne G. Krause U. Patel J. Vertommen D. Bertrand L. Lavoinne A. Hue L. Proud C. Rider M. 2002 Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis CurrBiol 12 1419 1423
14. Marin P. Nastiuk KL. Daniel N. Girault JA. Czernik AJ. Glowinski J. Nairn AC. Premont J. 1997 Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons JNeurosci 17 3445 3454
15. Maus M. Marin P. Israel M. Glowinski J. Premont J. 1999 Pyruvate and lactate protect striatal neurons against N-methyl- d -aspartate-induced neurotoxicity EurJNeurosci 11 3215 3224
16. McLeod LE. Proud CG. 2002 ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling FEBS Lett 531 448 452
17. Nairn AC. Palfrey HC. 1987 Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2 JBiolChem 262 17 299 17 303
18. Nairn AC. Matsushita M. Nastiuk K. Horiuchi A. Mitsui K. Shimizu Y. Palfrey HC. 2001 Elongation factor-2 phosphorylation and the regulation of protein synthesis by calcium ProgMolSubcell Biol 27 91 129
19. Petegnief V. Friguls B. Sanfeliu C. Sunol C. Planas AM. 2003 Transforming growth factor-αlpha attenuates N-methyl- d -aspartic acid toxicity in cortical cultures by preventing protein synthesis inhibition through an Erk1/2-dependent mechanism JBiolChem 278 29 552 29 559
20. Proud CG. 2002 Regulation of mammalian translation factors by nutrients EurJBiochem 269 5338 5349
21. Proud CG. 2004 mTOR-mediated regulation of translation factors by amino acids BiochemBiophysResCommun 313 429 436
22. Raley-Susman KM. Lipton P. 1990 In vitro ischemia and protein synthesis in the rat hippocampal slice: the role of calcium and NMDA receptor activation Brain Res 515 27 38
23. Ryazanov AG. 1987 Ca2+/calmodulin-dependent phosphorylation of elongation factor 2 FEBS Lett 214 331 334
24. Scheetz AJ. Nairn AC. Constantine-Paton M. 2000 NMDA receptor-mediated control of protein synthesis at developing synapses NatNeurosci 3 211 216
25. Smith PK. Krohn RI. Hermanson GT. Mallia AK. Gartner FH. Provenzano MD. Fujimoto EK. Goeke NM. Olson BJ. Klenk DC. 1985 Measurement of protein using bicinchoninic acid [published erratum appears in Anal. Biochem. 1987 May 15; 163(1): 279]. AnalBiochem 150 76 85
26. Stout AK. Raphael HM. Kanterewicz BI. Klann E. Reynolds IJ. 1998 Glutamate-induced neuron death requires mitochondrial calcium uptake NatNeurosci 1 366 373
27. Turnley AM. Stapleton D. Mann RJ. Witters LA. Kemp BE. Bartlett PF. 1999 Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system JNeurochem 72 1707 1716
28. Vergun O. Han YY. Reynolds IJ. 2003 Glucose deprivation produces a prolonged increase in sensitivity to glutamate in cultured rat cortical neurons ExpNeurol 183 682 694
29. Wang X. Li W. Williams M. Terada N. Alessi DR. Proud CG. 2001 Regulation of elongation factor 2 kinase by p90 (RSK1) and p70, S6 kinase EMBO J 20 4370 4379
30. Ward MW. Rego AC. Frenguelli BG. Nicholls DG. 2000 Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells JNeurosci 20 7208 7219
31. White RJ. Reynolds IJ. 1996 Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure JNeurosci 16 5688 5697
32. Yan L. Nairn AC. Palfrey HC. Brady MJ. 2003 Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells JBiolChem 278 18 177 18 183