메뉴 건너뛰기




Volumn 27, Issue 2, 2006, Pages 197-208

The molecular biology of vestibular schwannomas: Dissecting the pathogenic process at the molecular level

Author keywords

Acoustic neuroma; Merlin; Neurofibromatosis type 2; NF2 gene; Vestibular schwannoma

Indexed keywords

DNA; GENE PRODUCT; KI 67 ANTIGEN; MERLIN; MESSENGER RNA; NEUROFIBROMATOSIS TYPE 2 PROTEIN; PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 33645051945     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/01.mao.0000180484.24242.54     Document Type: Review
Times cited : (63)

References (114)
  • 1
    • 0033851545 scopus 로고    scopus 로고
    • Incidence of vestibular schwannoma in Denmark, 1977-1995
    • Howitz MF, Johansen C, Tos M, et al. Incidence of vestibular schwannoma in Denmark, 1977-1995. Am J Otol 2000;21: 690-4.
    • (2000) Am J Otol , vol.21 , pp. 690-694
    • Howitz, M.F.1    Johansen, C.2    Tos, M.3
  • 2
    • 0034081579 scopus 로고    scopus 로고
    • Prevalence of unsuspected acoustic neuroma found by magnetic resonance imaging
    • Anderson TD, Loevner LA, Bigelow DC, et al. Prevalence of unsuspected acoustic neuroma found by magnetic resonance imaging. Otolaryngol Head Neck Surg 2000;122:643-6.
    • (2000) Otolaryngol Head Neck Surg , vol.122 , pp. 643-646
    • Anderson, T.D.1    Loevner, L.A.2    Bigelow, D.C.3
  • 3
    • 0026588775 scopus 로고
    • Prevention and control of neurofibromatosis: Memorandum from a joint WHO/NNFF meeting
    • Bull. World Health Org. Prevention and control of neurofibromatosis: Memorandum from a joint WHO/NNFF meeting. Bull World Health Org 1992;70:173-82.
    • (1992) Bull World Health Org , vol.70 , pp. 173-182
  • 4
    • 0018821706 scopus 로고
    • Central neurofibromatosis with bilateral acoustic neuroma: Genetic, clinical and biochemical distinctions from peripheral neurofibromatosis
    • Kanter WR, Eldridge R, Fabricant R, et al. Central neurofibromatosis with bilateral acoustic neuroma: genetic, clinical and biochemical distinctions from peripheral neurofibromatosis. Neurology 1980;30:851-9.
    • (1980) Neurology , vol.30 , pp. 851-859
    • Kanter, W.R.1    Eldridge, R.2    Fabricant, R.3
  • 5
    • 0023854155 scopus 로고
    • Neurofibromatosis 2 (bilateral acoustic neurofibromatosis)
    • Martuza RL, Eldridge R. Neurofibromatosis 2 (bilateral acoustic neurofibromatosis). N Engl J Med 1988;318:684-8.
    • (1988) N Engl J Med , vol.318 , pp. 684-688
    • Martuza, R.L.1    Eldridge, R.2
  • 6
    • 0037058777 scopus 로고    scopus 로고
    • Evaluation of clinical diagnostic criteria for neurofibromatosis 2
    • Baser ME, Friedman JM, Wallace AJ, et al. Evaluation of clinical diagnostic criteria for neurofibromatosis 2. Neurology 2002;59:1759-65.
    • (2002) Neurology , vol.59 , pp. 1759-1765
    • Baser, M.E.1    Friedman, J.M.2    Wallace, A.J.3
  • 7
    • 11944267671 scopus 로고
    • A genetic study of type 2 neurofibromatosis in the United Kingdom: I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity
    • Evans DGR, Huson SM, Donnai D, et al. A genetic study of type 2 neurofibromatosis in the United Kingdom: I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity. J Med Genet 1992;29:841-6.
    • (1992) J Med Genet , vol.29 , pp. 841-846
    • Evans, D.G.R.1    Huson, S.M.2    Donnai, D.3
  • 8
    • 0001594018 scopus 로고
    • Case of tumors in the skull, dura mater, and brain
    • Wishart JH. Case of tumors in the skull, dura mater, and brain. Edinburgh Med Surg J 1822;18:393-7.
    • (1822) Edinburgh Med Surg J , vol.18 , pp. 393-397
    • Wishart, J.H.1
  • 9
    • 84944358578 scopus 로고
    • Bilateral acoustic neurofibromatosis: A clinical study and field survey of a family of five generations with bilateral deafness in thirty-eight members
    • Gardner WJ, Frazier CH. Bilateral acoustic neurofibromatosis: a clinical study and field survey of a family of five generations with bilateral deafness in thirty-eight members. Arch Neurol Psychiatry 1930;23:266-302.
    • (1930) Arch Neurol Psychiatry , vol.23 , pp. 266-302
    • Gardner, W.J.1    Frazier, C.H.2
  • 10
    • 0035849530 scopus 로고    scopus 로고
    • The clinical and diagnostic implications of mosaicism in neurofibromatosis
    • Ruggieri M, Huson SM. The clinical and diagnostic implications of mosaicism in neurofibromatosis. Neurology 2001;56:1433-43.
    • (2001) Neurology , vol.56 , pp. 1433-1443
    • Ruggieri, M.1    Huson, S.M.2
  • 11
    • 0037323824 scopus 로고    scopus 로고
    • Molecular study of frequency of mosaicism in neurofibromatosis 2 patients with bilateral vestibular schwannomas
    • Kluwe L, Mautner V, Heinrich B. Molecular study of frequency of mosaicism in neurofibromatosis 2 patients with bilateral vestibular schwannomas. J Med Genet 2003;40:109-14.
    • (2003) J Med Genet , vol.40 , pp. 109-114
    • Kluwe, L.1    Mautner, V.2    Heinrich, B.3
  • 12
    • 0038545702 scopus 로고    scopus 로고
    • Somatic mosaicism in neurofibromatosis 2: Prevalence and risk of disease transmission to offspring
    • Moyhuddin A, Baser MG, Watson C. Somatic mosaicism in neurofibromatosis 2: prevalence and risk of disease transmission to offspring. J Med Genet 2003;40:459-63.
    • (2003) J Med Genet , vol.40 , pp. 459-463
    • Moyhuddin, A.1    Baser, M.G.2    Watson, C.3
  • 13
    • 0038714575 scopus 로고    scopus 로고
    • Familial schwannomatosis: Exclusion of the NF2 locus as the germline event
    • MacCollin M, Willett C, Heinrich B, et al. Familial schwannomatosis: exclusion of the NF2 locus as the germline event. Neurology 2003;60:1968-74.
    • (2003) Neurology , vol.60 , pp. 1968-1974
    • MacCollin, M.1    Willett, C.2    Heinrich, B.3
  • 14
    • 0034353608 scopus 로고    scopus 로고
    • Cystic vestibular schwannoma: Clinical and experimental studies
    • Charabi S, Tos M, Thomsen J, et al. Cystic vestibular schwannoma: clinical and experimental studies. Acta Otolaryngol 2000;543(Suppl):11-3.
    • (2000) Acta Otolaryngol , vol.543 , Issue.SUPPL. , pp. 11-13
    • Charabi, S.1    Tos, M.2    Thomsen, J.3
  • 15
    • 0027999755 scopus 로고
    • Cystic acoustic neuromas: Results of translabyrinthine surgery
    • Charabi S, Tos M, Borgesen SE, et al. Cystic acoustic neuromas: results of translabyrinthine surgery. Arch Otolaryngol Head Neck Surg 1994;120:1333-8.
    • (1994) Arch Otolaryngol Head Neck Surg , vol.120 , pp. 1333-1338
    • Charabi, S.1    Tos, M.2    Borgesen, S.E.3
  • 16
    • 0034493618 scopus 로고    scopus 로고
    • Cystic vestibular schwannoma: Surgical outcome
    • Fundova P, Charabi S, Tos M, et al. Cystic vestibular schwannoma: surgical outcome. J Laryngol Otol 2000;114:935-9.
    • (2000) J Laryngol Otol , vol.114 , pp. 935-939
    • Fundova, P.1    Charabi, S.2    Tos, M.3
  • 17
    • 12644269198 scopus 로고
    • Acoustic neurinomas with macrocysts treated with gamma knife radiosurgery
    • Pendl G, Ganz JC, Kitz K, et al. Acoustic neurinomas with macrocysts treated with gamma knife radiosurgery. Stereotact Funct Neurosurg 1995;66(Suppl):103-11.
    • (1995) Stereotact Funct Neurosurg , vol.66 , Issue.SUPPL. , pp. 103-111
    • Pendl, G.1    Ganz, J.C.2    Kitz, K.3
  • 18
    • 0034565947 scopus 로고    scopus 로고
    • Fractionated stereotactic radiotherapy for vestibular schwannoma (VS): Comparison between cystic-type and solid-type VS
    • Shirato H, Sakamoto T, Takeichi N, et al. Fractionated stereotactic radiotherapy for vestibular schwannoma (VS): comparison between cystic-type and solid-type VS. Int J Radiat Oncol Biol Phys 2000;48:1395-401.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 1395-1401
    • Shirato, H.1    Sakamoto, T.2    Takeichi, N.3
  • 19
  • 20
    • 33645069280 scopus 로고    scopus 로고
    • Deregulation of the pRb-CDK pathway in vestibular schwannomas
    • Lasak JM, Welling DB, Salloum M, et al. Deregulation of the pRb-CDK pathway in vestibular schwannomas. Laryngoscope 2001;112:1555-61.
    • (2001) Laryngoscope , vol.112 , pp. 1555-1561
    • Lasak, J.M.1    Welling, D.B.2    Salloum, M.3
  • 21
    • 0023204436 scopus 로고
    • Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22
    • Rouleau GA, Wertelecki W, Haines JL, et al. Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 1987;329:246-8.
    • (1987) Nature , vol.329 , pp. 246-248
    • Rouleau, G.A.1    Wertelecki, W.2    Haines, J.L.3
  • 22
    • 0023687891 scopus 로고
    • Neurofibromatosis 2: Clinical and DNA linkage studies of a larger kindred
    • Wertelecki W, Rouleau GA, Superneau DW, et al. Neurofibromatosis 2: clinical and DNA linkage studies of a larger kindred. N Engl J Med 1988;319:278-83.
    • (1988) N Engl J Med , vol.319 , pp. 278-283
    • Wertelecki, W.1    Rouleau, G.A.2    Superneau, D.W.3
  • 23
    • 0027245423 scopus 로고
    • Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2
    • Rouleau GA, Merel P, Lutchman M, et al. Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2. Nature 1993;363:515-21.
    • (1993) Nature , vol.363 , pp. 515-521
    • Rouleau, G.A.1    Merel, P.2    Lutchman, M.3
  • 24
    • 0027405720 scopus 로고
    • A novel Moesin-, Exrin-, Radixin-like gene is a candidate for the neurofibromatosis 2 tumor-suppressor
    • Trofatter JA, MacCollin MM, Rutter JL, et al. A novel Moesin-, Exrin-, Radixin-like gene is a candidate for the neurofibromatosis 2 tumor-suppressor. Cell 1993;72:791-800.
    • (1993) Cell , vol.72 , pp. 791-800
    • Trofatter, J.A.1    MacCollin, M.M.2    Rutter, J.L.3
  • 25
    • 8944256090 scopus 로고    scopus 로고
    • Mutational spectrums in the neurofibromatosis type 2 gene in sporadic and familial schwannomas
    • Welling DB, Guida M, Goll F, et al. Mutational spectrums in the neurofibromatosis type 2 gene in sporadic and familial schwannomas. Hum Genet 1996;98:189-93.
    • (1996) Hum Genet , vol.98 , pp. 189-193
    • Welling, D.B.1    Guida, M.2    Goll, F.3
  • 26
    • 0028837397 scopus 로고
    • Screening for germ-line mutations in the NF2 gene
    • Merel P, Khe HX, Sanson M, et al. Screening for germ-line mutations in the NF2 gene. Genes Chromosome Cancer 1995;12:117-2.
    • (1995) Genes Chromosome Cancer , vol.12 , pp. 117-122
    • Merel, P.1    Khe, H.X.2    Sanson, M.3
  • 27
    • 0028142499 scopus 로고
    • Mutational analysis of patients with neurofibromatosis 2
    • MacCollin M, Ramesh V, Jacoby LB, et al. Mutational analysis of patients with neurofibromatosis 2. Am J Hum Genet 1994;55:314-20.
    • (1994) Am J Hum Genet , vol.55 , pp. 314-320
    • MacCollin, M.1    Ramesh, V.2    Jacoby, L.B.3
  • 28
    • 0028326668 scopus 로고
    • Exon scanning for mutation of the NF2 gene in schwannomas
    • Jacoby LB, MacCollin M, Louis DN, et al. Exon scanning for mutation of the NF2 gene in schwannomas. Hum Mol Genet 1994;3:413-9.
    • (1994) Hum Mol Genet , vol.3 , pp. 413-419
    • Jacoby, L.B.1    MacCollin, M.2    Louis, D.N.3
  • 29
    • 0029811044 scopus 로고    scopus 로고
    • Identification of NF2 germ-line mutations and comparison with neurofibromatosis 2 phenotypes
    • Kluwe L, Bayer S, Baser ME, et al. Identification of NF2 germ-line mutations and comparison with neurofibromatosis 2 phenotypes. Hum Genet 1996;98:534-8.
    • (1996) Hum Genet , vol.98 , pp. 534-538
    • Kluwe, L.1    Bayer, S.2    Baser, M.E.3
  • 30
    • 0029774092 scopus 로고    scopus 로고
    • Germline mutations in the neurofibromatosis 2 gene: Correlation with disease severity and retinal abnormalities
    • Parry DM, MacCollin MM, Kaiser-Kupfer MI, et al. Germline mutations in the neurofibromatosis 2 gene: correlation with disease severity and retinal abnormalities. Am J Hum Genet 1996;59:529-3.
    • (1996) Am J Hum Genet , vol.59 , pp. 529-533
    • Parry, D.M.1    MacCollin, M.M.2    Kaiser-Kupfer, M.I.3
  • 31
    • 19244362433 scopus 로고    scopus 로고
    • Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease
    • Ruttledge MH, Andermann AA, Phelan CM, et al. Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease. Am J Hum Genet 1996;59:331-42.
    • (1996) Am J Hum Genet , vol.59 , pp. 331-342
    • Ruttledge, M.H.1    Andermann, A.A.2    Phelan, C.M.3
  • 32
    • 0030012984 scopus 로고    scopus 로고
    • Phenotypic variability in two families with novel splice-site and frameshift NF2 mutations
    • Mautner VF, Baser ME, Kluwe L. Phenotypic variability in two families with novel splice-site and frameshift NF2 mutations. Hum Genet 1996;98:203-6.
    • (1996) Hum Genet , vol.98 , pp. 203-206
    • Mautner, V.F.1    Baser, M.E.2    Kluwe, L.3
  • 34
    • 0031799509 scopus 로고    scopus 로고
    • Genotype/phenotype correlations in type 2 neurofibromatosis (NF2): Evidence for more severe disease associated with truncating mutations
    • Evans DG, Trueman L, Wallace A, et al. Genotype/phenotype correlations in type 2 neurofibromatosis (NF2): evidence for more severe disease associated with truncating mutations. J Med Genet 1998;35:450-5.
    • (1998) J Med Genet , vol.35 , pp. 450-455
    • Evans, D.G.1    Trueman, L.2    Wallace, A.3
  • 35
    • 0033760978 scopus 로고    scopus 로고
    • Genetic aberrations in sporadic and neurofibromatosis 2 (NF2)-associated schwannomas studied by comparative genomic hybridization (CGH)
    • Antinheimo J, Sallinen SL, Sallinen P, et al. Genetic aberrations in sporadic and neurofibromatosis 2 (NF2)-associated schwannomas studied by comparative genomic hybridization (CGH). Acta Neurochir (Wien) 2000;142:1099-104.
    • (2000) Acta Neurochir (Wien) , vol.142 , pp. 1099-1104
    • Antinheimo, J.1    Sallinen, S.L.2    Sallinen, P.3
  • 36
    • 0034656174 scopus 로고    scopus 로고
    • Neurofibromatosis 2 phenotypes and germ-line NF2 mutations determined by an RNA mismatch method and loss of heterozygosity analysis in NF2 schwannomas
    • Hung G, Faudoa R, Baser ME, et al. Neurofibromatosis 2 phenotypes and germ-line NF2 mutations determined by an RNA mismatch method and loss of heterozygosity analysis in NF2 schwannomas. Cancer Genet Cytogenet 2000;118:167-8.
    • (2000) Cancer Genet Cytogenet , vol.118 , pp. 167-168
    • Hung, G.1    Faudoa, R.2    Baser, M.E.3
  • 37
    • 0031929738 scopus 로고    scopus 로고
    • Clinical manifestations of mutations in the neurofibromatosis type 2 gene in vestibular schwannomas (acoustic neuromas)
    • Welling DB. Clinical manifestations of mutations in the neurofibromatosis type 2 gene in vestibular schwannomas (acoustic neuromas). Laryngoscope 1998;108:178-89.
    • (1998) Laryngoscope , vol.108 , pp. 178-189
    • Welling, D.B.1
  • 38
    • 0029794048 scopus 로고    scopus 로고
    • Frequency and distribution of NF2 mutations in schwannomas
    • Jacoby LB, MacCollin M, Barone R, et al. Frequency and distribution of NF2 mutations in schwannomas. Genes Chromosomes Cancer 1996;17:45-55.
    • (1996) Genes Chromosomes Cancer , vol.17 , pp. 45-55
    • Jacoby, L.B.1    MacCollin, M.2    Barone, R.3
  • 39
    • 0029004033 scopus 로고
    • Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas
    • Merel P, Hoang-Xuan K, Sanson M, et al. Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Genes Chromosomes Cancer 1995;13:1211-6.
    • (1995) Genes Chromosomes Cancer , vol.13 , pp. 1211-1216
    • Merel, P.1    Hoang-Xuan, K.2    Sanson, M.3
  • 40
    • 0028201083 scopus 로고
    • Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types
    • Bianchi AB, Hara T, Ramesh V, et al. Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet 1994;6:185-92.
    • (1994) Nat Genet , vol.6 , pp. 185-192
    • Bianchi, A.B.1    Hara, T.2    Ramesh, V.3
  • 41
    • 0028264119 scopus 로고
    • Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas
    • Ruttledge MH, Sarrazin J, Rangaratnam S, et al. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet 1994;6:180-4.
    • (1994) Nat Genet , vol.6 , pp. 180-184
    • Ruttledge, M.H.1    Sarrazin, J.2    Rangaratnam, S.3
  • 42
    • 0031874488 scopus 로고    scopus 로고
    • Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene
    • Deguen B, Goutebroze L, Giovannini M, et al. Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene. Int J Cancer 1998;77:554-60.
    • (1998) Int J Cancer , vol.77 , pp. 554-560
    • Deguen, B.1    Goutebroze, L.2    Giovannini, M.3
  • 43
    • 0028054663 scopus 로고
    • Somatic NF2 gene mutations in familial and non-familial vestibular schwannoma
    • Irving RM, Moffat DA, Hardy DG, et al. Somatic NF2 gene mutations in familial and non-familial vestibular schwannoma. Hum Mol Genet 1994;3:347-50.
    • (1994) Hum Mol Genet , vol.3 , pp. 347-350
    • Irving, R.M.1    Moffat, D.A.2    Hardy, D.G.3
  • 44
    • 0028796960 scopus 로고
    • High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons
    • Sainz J, Figueroa K, Baser ME, et al. High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons. Hum Genet 1995;4:137-9.
    • (1995) Hum Genet , vol.4 , pp. 137-139
    • Sainz, J.1    Figueroa, K.2    Baser, M.E.3
  • 45
    • 0028343217 scopus 로고
    • Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas
    • Sainz J, Huynh DP, Figueroa K, et al. Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Hum Mol Genet 1994;3:885-91.
    • (1994) Hum Mol Genet , vol.3 , pp. 885-891
    • Sainz, J.1    Huynh, D.P.2    Figueroa, K.3
  • 46
    • 0031887651 scopus 로고    scopus 로고
    • Defects in neurofibromatosis 2 protein function can arise at multiple levels
    • Gutmann DH, Geist RT, Xu H, et al. Defects in neurofibromatosis 2 protein function can arise at multiple levels. Hum Mol Genet 1998;7:335-4.
    • (1998) Hum Mol Genet , vol.7 , pp. 335-344
    • Gutmann, D.H.1    Geist, R.T.2    Xu, H.3
  • 47
    • 0033940009 scopus 로고    scopus 로고
    • Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations
    • Stokowski RP, Cox DR. Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations. Am J Hum Genet 2000;66:873-91.
    • (2000) Am J Hum Genet , vol.66 , pp. 873-891
    • Stokowski, R.P.1    Cox, D.R.2
  • 48
    • 0035394852 scopus 로고    scopus 로고
    • Functional analysis of neurofibromatosis 2 (NF2) missense mutations
    • Gutmann DH, Hirbe AC, Haipek CA. Functional analysis of neurofibromatosis 2 (NF2) missense mutations. Hum Mol Genet 2001;10:1519-2.
    • (2001) Hum Mol Genet , vol.10 , pp. 1519-1522
    • Gutmann, D.H.1    Hirbe, A.C.2    Haipek, C.A.3
  • 49
    • 0035252636 scopus 로고    scopus 로고
    • High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH
    • Bruder DEG, Kirvela C, Tapia-Paez I, et al. High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH. Hum Mol Genet 2001;10:271-82.
    • (2001) Hum Mol Genet , vol.10 , pp. 271-282
    • Bruder, D.E.G.1    Kirvela, C.2    Tapia-Paez, I.3
  • 50
    • 0032956279 scopus 로고    scopus 로고
    • Severe phenotype of neurofibromatosis type 2 in a patient with a 7.4-MB constitutional deletion on chromosome 22: Possible localization of a neurofibromatosis type 2 modifier gene?
    • Bruder CE, Ichimura K, Blennow E, et al. Severe phenotype of neurofibromatosis type 2 in a patient with a 7.4-MB constitutional deletion on chromosome 22: possible localization of a neurofibromatosis type 2 modifier gene? Genes Chromosomes Cancer 1999;25:184-90.
    • (1999) Genes Chromosomes Cancer , vol.25 , pp. 184-190
    • Bruder, C.E.1    Ichimura, K.2    Blennow, E.3
  • 51
    • 6644226164 scopus 로고    scopus 로고
    • Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma
    • Kino T, Takeshima H, Nakao M, et al. Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma. Genes Cells 2001;6:441-54.
    • (2001) Genes Cells , vol.6 , pp. 441-454
    • Kino, T.1    Takeshima, H.2    Nakao, M.3
  • 52
    • 0035703466 scopus 로고    scopus 로고
    • Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts
    • Chang LS, Akhmametyeva EM, Wu Y, et al. Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts. Genomics 2002;79:63-76.
    • (2002) Genomics , vol.79 , pp. 63-76
    • Chang, L.S.1    Akhmametyeva, E.M.2    Wu, Y.3
  • 53
    • 0028576863 scopus 로고
    • An exon 8-spliced out transcript of neurofibromatosis 2 gene is constitutively expressed in various human tissues
    • Hitotsumatsu T, Kitamoto T, Iwaki T, et al. An exon 8-spliced out transcript of neurofibromatosis 2 gene is constitutively expressed in various human tissues. J Biochem 1994;116:1205-7.
    • (1994) J Biochem , vol.116 , pp. 1205-1207
    • Hitotsumatsu, T.1    Kitamoto, T.2    Iwaki, T.3
  • 54
    • 0028265331 scopus 로고
    • The neurofibromatosis type 2 tumor suppressor gene encodes multiple alternatively spliced transcripts
    • Pykett MJ, Murphy M, Harnish PR, et al. The neurofibromatosis type 2 tumor suppressor gene encodes multiple alternatively spliced transcripts. Hum Mol Genet 1994;3:559-64.
    • (1994) Hum Mol Genet , vol.3 , pp. 559-564
    • Pykett, M.J.1    Murphy, M.2    Harnish, P.R.3
  • 55
    • 0033561026 scopus 로고    scopus 로고
    • Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein
    • Giovannini M, Robanus-Maandag E, Niwa-Kawakita M, et al. Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Genes Dev 1999;13:978-86.
    • (1999) Genes Dev , vol.13 , pp. 978-986
    • Giovannini, M.1    Robanus-Maandag, E.2    Niwa-Kawakita, M.3
  • 56
    • 0033782082 scopus 로고    scopus 로고
    • Analysis of the human neurofibromatosis type 2 gene promoter and its expression
    • Welling DB, Akhmametyeva EM, Daniels RL, et al. Analysis of the human neurofibromatosis type 2 gene promoter and its expression. Otolaryngol Head Neck Surg 2000;123:413-8.
    • (2000) Otolaryngol Head Neck Surg , vol.123 , pp. 413-418
    • Welling, D.B.1    Akhmametyeva, E.M.2    Daniels, R.L.3
  • 57
    • 0031683065 scopus 로고    scopus 로고
    • The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane
    • Chishti AH, Kim AC, Marfatia SM, et al. The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci 1998;23:281-2.
    • (1998) Trends Biochem Sci , vol.23 , pp. 281-282
    • Chishti, A.H.1    Kim, A.C.2    Marfatia, S.M.3
  • 58
    • 0034524664 scopus 로고    scopus 로고
    • ERM-Merlin and EBP50 protein families in plasma membrane organization and function
    • Bretscher A, Chambers D, Nguyen R, et al. ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Annu Rev Cell Dev Biol 2000;16:113-43.
    • (2000) Annu Rev Cell Dev Biol , vol.16 , pp. 113-143
    • Bretscher, A.1    Chambers, D.2    Nguyen, R.3
  • 59
    • 0027933858 scopus 로고
    • Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
    • Turunen O, Wahlstrom T, Vaheri A. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J Cell Biol 1994;126:1445-53.
    • (1994) J Cell Biol , vol.126 , pp. 1445-1453
    • Turunen, O.1    Wahlstrom, T.2    Vaheri, A.3
  • 60
    • 0030835761 scopus 로고    scopus 로고
    • A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding
    • Roy C, Martin M, Mangeat P. A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding. J Biol Chem 1997;272:20088-95.
    • (1997) J Biol Chem , vol.272 , pp. 20088-20095
    • Roy, C.1    Martin, M.2    Mangeat, P.3
  • 61
    • 0029827053 scopus 로고    scopus 로고
    • The merlin tumor suppressor localizes preferentially in membrane ruffles
    • Gonzalez-Agosti C, Xu L, Pinney D, et al. The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene 1996;13:1239-47.
    • (1996) Oncogene , vol.13 , pp. 1239-1247
    • Gonzalez-Agosti, C.1    Xu, L.2    Pinney, D.3
  • 62
    • 0032578798 scopus 로고    scopus 로고
    • Ruffling membrane, stress fiber, cell spreading, and proliferation abnormalities in human schwannoma cells
    • Pelton PD, Sherman LS, Rizvi TA, et al. Ruffling membrane, stress fiber, cell spreading, and proliferation abnormalities in human schwannoma cells. Oncogene 1998;17:2195-209.
    • (1998) Oncogene , vol.17 , pp. 2195-2209
    • Pelton, P.D.1    Sherman, L.S.2    Rizvi, T.A.3
  • 63
    • 0031964774 scopus 로고    scopus 로고
    • Impaired interaction of naturally occurring mutant NF2 protein with actin-based cytoskeleton and membrane
    • Deguen B, Merel P, Goutebroze L, et al. Impaired interaction of naturally occurring mutant NF2 protein with actin-based cytoskeleton and membrane. Hum Mol Genet 1998;7:217-26.
    • (1998) Hum Mol Genet , vol.7 , pp. 217-226
    • Deguen, B.1    Merel, P.2    Goutebroze, L.3
  • 64
    • 0029077821 scopus 로고
    • The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells
    • Lutchman M, Rouleau GA. The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells. Cancer Res 1995;55:2270-4.
    • (1995) Cancer Res , vol.55 , pp. 2270-2274
    • Lutchman, M.1    Rouleau, G.A.2
  • 65
    • 0028168361 scopus 로고
    • An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin)
    • Tikoo A, Varga M, Ramesh V, et al. An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin). J Biol Chem 1994;269:23387-90.
    • (1994) J Biol Chem , vol.269 , pp. 23387-23390
    • Tikoo, A.1    Varga, M.2    Ramesh, V.3
  • 66
    • 0032522603 scopus 로고    scopus 로고
    • Mice heterozygous for a mutation at the NF2 tumor suppressor locus develop a range of highly metastatic tumors
    • McClatchey AI, Saotome I, Mercer K, et al. Mice heterozygous for a mutation at the NF2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 1998;12:1121-33.
    • (1998) Genes Dev , vol.12 , pp. 1121-1133
    • McClatchey, A.I.1    Saotome, I.2    Mercer, K.3
  • 67
    • 0030924657 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation
    • McClatchey AI, Saotome I, Ramesh V, et al. The NF2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev 1997;11:1253-65.
    • (1997) Genes Dev , vol.11 , pp. 1253-1265
    • McClatchey, A.I.1    Saotome, I.2    Ramesh, V.3
  • 68
    • 0034234894 scopus 로고    scopus 로고
    • Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
    • Giovannini M, Robanus-Maandag E, van der Valk M, et al. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev 2000;14:1617-30.
    • (2000) Genes Dev , vol.14 , pp. 1617-1630
    • Giovannini, M.1    Robanus-Maandag, E.2    Van Der Valk, M.3
  • 69
    • 18044399847 scopus 로고    scopus 로고
    • The NF2 tumor suppressor, merlin, functions in Rac-dependent signaling
    • Shaw RJ, Paez JG, Curto M, et al. The NF2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell 2001;1:63-72.
    • (2001) Dev Cell , vol.1 , pp. 63-72
    • Shaw, R.J.1    Paez, J.G.2    Curto, M.3
  • 70
    • 0036699082 scopus 로고    scopus 로고
    • Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology
    • Fernandez-Valle C, Tang Y, Ricard J, et al. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology. Nat Genet 2000;31:354-62.
    • (2000) Nat Genet , vol.31 , pp. 354-362
    • Fernandez-Valle, C.1    Tang, Y.2    Ricard, J.3
  • 71
    • 3042611874 scopus 로고    scopus 로고
    • Merlin links to the cAMP neuronal signaling pathway by anchoring the R1 beta subunit of protein kinase A
    • Gronholm M, Vossebein L, Carlson CR, et al. Merlin links to the cAMP neuronal signaling pathway by anchoring the R1 beta subunit of protein kinase A. J Biol Chem 2003;278:41167-72.
    • (2003) J Biol Chem , vol.278 , pp. 41167-41172
    • Gronholm, M.1    Vossebein, L.2    Carlson, C.R.3
  • 72
    • 0242298576 scopus 로고    scopus 로고
    • Merlin, the product of the NF2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, PAK1
    • Kissil JL, Wilker EW, Johnson KC, et al. Merlin, the product of the NF2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, PAK1. Mol Cell 2003;12:841-9.
    • (2003) Mol Cell , vol.12 , pp. 841-849
    • Kissil, J.L.1    Wilker, E.W.2    Johnson, K.C.3
  • 73
    • 0028245681 scopus 로고
    • Detection of cellular proteins that interact with the NF2 tumor suppressor gene product
    • Takeshima H, Izawa I, Lee PS, et al. Detection of cellular proteins that interact with the NF2 tumor suppressor gene product. Oncogene 1994;9:2135-44.
    • (1994) Oncogene , vol.9 , pp. 2135-2144
    • Takeshima, H.1    Izawa, I.2    Lee, P.S.3
  • 74
    • 0030759923 scopus 로고    scopus 로고
    • Neurofibromatosis 2 tumor suppressor protein co-localizes with ezrin and CD44 and associates with actin-containing cytoskeleton
    • Sainio M, Zhao F, Heiska L, et al. Neurofibromatosis 2 tumor suppressor protein co-localizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J Cell Sci 1997;110:2249-60.
    • (1997) J Cell Sci , vol.110 , pp. 2249-2260
    • Sainio, M.1    Zhao, F.2    Heiska, L.3
  • 75
    • 0032581339 scopus 로고    scopus 로고
    • Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions
    • Huang L, Ichimaru E, Pestonjamasp K, et al. Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions. Biochim Biophys Res Commun 1998;248:548-53.
    • (1998) Biochim Biophys Res Commun , vol.248 , pp. 548-553
    • Huang, L.1    Ichimaru, E.2    Pestonjamasp, K.3
  • 76
    • 0031890998 scopus 로고    scopus 로고
    • NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
    • Murthy A, Gonzalez-Agosti C, Cordero E, et al. NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem 1998;273:1273-6.
    • (1998) J Biol Chem , vol.273 , pp. 1273-1276
    • Murthy, A.1    Gonzalez-Agosti, C.2    Cordero, E.3
  • 77
    • 0031738241 scopus 로고    scopus 로고
    • Merlin, the neurofibromatosis type 2 gene product, and β1 integrin associate in isolated and differentiating Schwann cells
    • Obremski VJ, Hall AM, Fernandez-Valle C. Merlin, the neurofibromatosis type 2 gene product, and β1 integrin associate in isolated and differentiating Schwann cells. J Neurobiol 1998;37:487-501.
    • (1998) J Neurobiol , vol.37 , pp. 487-501
    • Obremski, V.J.1    Hall, A.M.2    Fernandez-Valle, C.3
  • 78
    • 0031896691 scopus 로고    scopus 로고
    • Neurofibromatosis 2 tumor suppressor schwannomin interacts with βII-spectrin
    • Scoles DR, Huynh DP, Morcos PA, et al. Neurofibromatosis 2 tumor suppressor schwannomin interacts with βII-spectrin. Nat Genet 1998;18:354-9.
    • (1998) Nat Genet , vol.18 , pp. 354-359
    • Scoles, D.R.1    Huynh, D.P.2    Morcos, P.A.3
  • 79
    • 0034234579 scopus 로고    scopus 로고
    • The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate
    • Scoles DR, Huynh DP, Chen MS, et al. The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Hum Mol Genet 2000;9:1567-74.
    • (2000) Hum Mol Genet , vol.9 , pp. 1567-1574
    • Scoles, D.R.1    Huynh, D.P.2    Chen, M.S.3
  • 80
    • 0032005305 scopus 로고    scopus 로고
    • Merlin differentially associates with the microtubule and actin cytoskeleton
    • Xu HM, Gutmann DH. Merlin differentially associates with the microtubule and actin cytoskeleton. J Neurosci Res 1998;51:403-15.
    • (1998) J Neurosci Res , vol.51 , pp. 403-415
    • Xu, H.M.1    Gutmann, D.H.2
  • 81
    • 0033970229 scopus 로고    scopus 로고
    • Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins
    • Goutebroze L, Brault E, Muchardt C, et al. Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol 2000;20:1699-712.
    • (2000) Mol Cell Biol , vol.20 , pp. 1699-1712
    • Goutebroze, L.1    Brault, E.2    Muchardt, C.3
  • 82
    • 0033941950 scopus 로고    scopus 로고
    • CD44 acts both as a growth and invasiveness-promoting molecule and as a tumor-suppressing cofactor
    • Herrlich P, Morrison H, Sleeman J, et al. CD44 acts both as a growth and invasiveness-promoting molecule and as a tumor-suppressing cofactor. Ann N Y Acad Sci 2000;910:106-18.
    • (2000) Ann N Y Acad Sci , vol.910 , pp. 106-118
    • Herrlich, P.1    Morrison, H.2    Sleeman, J.3
  • 83
    • 0027956397 scopus 로고
    • Hyaluronate receptors: Key players in growth, differentiation, migration, and tumor progression
    • Sherman L, Sleeman J, Herrlich P, et al. Hyaluronate receptors: key players in growth, differentiation, migration, and tumor progression. Curr Opin Cell Biol 1994;6:726-33.
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 726-733
    • Sherman, L.1    Sleeman, J.2    Herrlich, P.3
  • 84
    • 0035871299 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
    • Morrison H, Sherman LS, Legg J, et al. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 2001;15:968-80.
    • (2001) Genes Dev , vol.15 , pp. 968-980
    • Morrison, H.1    Sherman, L.S.2    Legg, J.3
  • 85
    • 0037059807 scopus 로고    scopus 로고
    • P21-activated kinase links Rac/Cdc42 signaling to merlin
    • Xiao GH, Beeser A, Chernoff J, et al. P21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 2002;277:883-6.
    • (2002) J Biol Chem , vol.277 , pp. 883-886
    • Xiao, G.H.1    Beeser, A.2    Chernoff, J.3
  • 86
    • 0037155916 scopus 로고    scopus 로고
    • Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization
    • Kissil JL, Johnson KC, Eckman MS, et al. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 2002;277:10394-9.
    • (2002) J Biol Chem , vol.277 , pp. 10394-10399
    • Kissil, J.L.1    Johnson, K.C.2    Eckman, M.S.3
  • 87
    • 0031471375 scopus 로고    scopus 로고
    • Ezrin: A protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures
    • Bretscher A, Reczek D, Berryman M. Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci 1997;110:3011-8.
    • (1997) J Cell Sci , vol.110 , pp. 3011-3018
    • Bretscher, A.1    Reczek, D.2    Berryman, M.3
  • 88
    • 0029795488 scopus 로고    scopus 로고
    • Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: Possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
    • Hirao M, Sato N, Kondo T, et al. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol 1996;135:37-51.
    • (1996) J Cell Biol , vol.135 , pp. 37-51
    • Hirao, M.1    Sato, N.2    Kondo, T.3
  • 89
    • 0032899713 scopus 로고    scopus 로고
    • Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading
    • Gutmann DH, Sherman L, Seftor L, et al. Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading. Hum Mol Genet 1999;8:267-75.
    • (1999) Hum Mol Genet , vol.8 , pp. 267-275
    • Gutmann, D.H.1    Sherman, L.2    Seftor, L.3
  • 90
    • 0035311373 scopus 로고    scopus 로고
    • The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the 'open' conformation and suppresses cell growth and motility
    • Gutmann DH, Haipek CA, Burke SP, et al. The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the 'open' conformation and suppresses cell growth and motility. Hum Mol Genet 2001;10:825-34.
    • (2001) Hum Mol Genet , vol.10 , pp. 825-834
    • Gutmann, D.H.1    Haipek, C.A.2    Burke, S.P.3
  • 91
    • 0034724536 scopus 로고    scopus 로고
    • Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
    • Pearson MA, Reczek D, Bretscher A, et al. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 2000;101:259-70.
    • (2000) Cell , vol.101 , pp. 259-270
    • Pearson, M.A.1    Reczek, D.2    Bretscher, A.3
  • 92
    • 0028849793 scopus 로고
    • Growth factor-induced tyrosine phosphorylation of HRS, a novel 115- kilodalton protein with a structurally conserved putative zinc finger domain
    • Komada M, Kitamura N. Growth factor-induced tyrosine phosphorylation of HRS, a novel 115- kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol 1995;15:6213-21.
    • (1995) Mol Cell Biol , vol.15 , pp. 6213-6221
    • Komada, M.1    Kitamura, N.2
  • 93
    • 0033674451 scopus 로고    scopus 로고
    • Correlation between Ki-67 index and some clinical aspects of acoustic neuromas (vestibular schwannomas)
    • Niemczyk K, Vaneecloo FN, Lecomte MH, et al. Correlation between Ki-67 index and some clinical aspects of acoustic neuromas (vestibular schwannomas). Otolaryngol Head Neck Surg 2000;123:779-83.
    • (2000) Otolaryngol Head Neck Surg , vol.123 , pp. 779-783
    • Niemczyk, K.1    Vaneecloo, F.N.2    Lecomte, M.H.3
  • 94
    • 0035180869 scopus 로고    scopus 로고
    • Atypical and low-grade malignant vestibular schwannomas: Clinical implications of proliferative activity
    • Light JP, Roland JT Jr, Fishman A, et al. Atypical and low-grade malignant vestibular schwannomas: clinical implications of proliferative activity. Otol Neurotol 2001;22:922-7.
    • (2001) Otol Neurotol , vol.22 , pp. 922-927
    • Light, J.P.1    Roland Jr., J.T.2    Fishman, A.3
  • 95
    • 0031734441 scopus 로고    scopus 로고
    • A study of vestibular schwannomas using positron emission tomography and monoclonal antibody Ki-67
    • Chen JM, Houle S, Ang LC, et al. A study of vestibular schwannomas using positron emission tomography and monoclonal antibody Ki-67. Am J Otol 1998;19:840-5.
    • (1998) Am J Otol , vol.19 , pp. 840-845
    • Chen, J.M.1    Houle, S.2    Ang, L.C.3
  • 97
    • 0028032678 scopus 로고
    • Histopathology and growth pattern of cystic acoustic neuromas
    • Charabi S, Klinken L, Tos M, et al. Histopathology and growth pattern of cystic acoustic neuromas. Laryngoscope 1994;104:1348-52.
    • (1994) Laryngoscope , vol.104 , pp. 1348-1352
    • Charabi, S.1    Klinken, L.2    Tos, M.3
  • 98
    • 0028860907 scopus 로고
    • Proliferative potential of sporadic and neurofibromatosis 2-associated schwannomas as studied by MIB-1 (Ki-67) and PCNA labeling
    • Antinheimo J, Haapasalo H, Seppala M, et al. Proliferative potential of sporadic and neurofibromatosis 2-associated schwannomas as studied by MIB-1 (Ki-67) and PCNA labeling. J Neuropathol Exp Neurol 1995;54:776-82.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 776-782
    • Antinheimo, J.1    Haapasalo, H.2    Seppala, M.3
  • 99
    • 0032904265 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 expression in human acoustic neuroma
    • Cardillo MR, Filipo R, Monini S, et al. Transforming growth factor-beta1 expression in human acoustic neuroma. Am J Otol 1999;20:65-8.
    • (1999) Am J Otol , vol.20 , pp. 65-68
    • Cardillo, M.R.1    Filipo, R.2    Monini, S.3
  • 101
    • 0029981434 scopus 로고    scopus 로고
    • The neuroimaging and clinical spectrum of neurofibromatosis 2
    • Mautner VF, Lindenau M, Baser ME, et al. The neuroimaging and clinical spectrum of neurofibromatosis 2. Neurosurgery 1996;38:880-85.
    • (1996) Neurosurgery , vol.38 , pp. 880-885
    • Mautner, V.F.1    Lindenau, M.2    Baser, M.E.3
  • 102
    • 0029111478 scopus 로고
    • Presymptomatic DNA and MRI diagnosis of neurofibromatosis 2 with mild clinical course in an extended pedigree
    • Sainio M, Strachan T, Blomstedt G, et al. Presymptomatic DNA and MRI diagnosis of neurofibromatosis 2 with mild clinical course in an extended pedigree. Neurology 1995;45:1314-22.
    • (1995) Neurology , vol.45 , pp. 1314-1322
    • Sainio, M.1    Strachan, T.2    Blomstedt, G.3
  • 103
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Lenton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature 2001;409:860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Lenton, L.M.2    Birren, B.3
  • 104
    • 0034659898 scopus 로고    scopus 로고
    • Genomics, gene expression, and DNA arrays
    • Lockhart DJ, Winzeler EA. Genomics, gene expression, and DNA arrays. Nature 2000;405:827-36.
    • (2000) Nature , vol.405 , pp. 827-836
    • Lockhart, D.J.1    Winzeler, E.A.2
  • 105
    • 0030669030 scopus 로고    scopus 로고
    • Exploring the metabolic and genetic control of gene expression on a genomic scale
    • DeRisi JL, Iyer VR, Brown PO. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 1997;278:680-6.
    • (1997) Science , vol.278 , pp. 680-686
    • DeRisi, J.L.1    Iyer, V.R.2    Brown, P.O.3
  • 106
    • 0141927384 scopus 로고    scopus 로고
    • Tissue microarray study for classification of breast tumors
    • Zhang DH, Salto-Tellez M, Chiu LL, et al. Tissue microarray study for classification of breast tumors. Life Sci 2003;73:3189-99.
    • (2003) Life Sci , vol.73 , pp. 3189-3199
    • Zhang, D.H.1    Salto-Tellez, M.2    Chiu, L.L.3
  • 107
    • 0141816860 scopus 로고    scopus 로고
    • Diagnostic markers that distinguish colon and ovarian adenocarcinomas: Identification, genomic, proteomic, and tissue array profiling
    • Nishizuku S, Chen ST, Gwadry FG, et al. Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification, genomic, proteomic, and tissue array profiling. Cancer Res 2003;63:5243-50.
    • (2003) Cancer Res , vol.63 , pp. 5243-5250
    • Nishizuku, S.1    Chen, S.T.2    Gwadry, F.G.3
  • 108
    • 0034812859 scopus 로고    scopus 로고
    • Towards a novel classification of human malignancies based on gene expression patterns
    • Alizadeh AA, Ross DT, Perou CM, et al. Towards a novel classification of human malignancies based on gene expression patterns. J Pathol 2001;195:41-52.
    • (2001) J Pathol , vol.195 , pp. 41-52
    • Alizadeh, A.A.1    Ross, D.T.2    Perou, C.M.3
  • 109
    • 0036234659 scopus 로고    scopus 로고
    • Unique molecular and cellular features of acute myelogenous leukemia stem cells
    • Jordan CT. Unique molecular and cellular features of acute myelogenous leukemia stem cells. Leukemia 2002;16:559-62.
    • (2002) Leukemia , vol.16 , pp. 559-562
    • Jordan, C.T.1
  • 110
    • 0032611040 scopus 로고    scopus 로고
    • Cancer, genomics, and the National Cancer Institute
    • Klausner RD. Cancer, genomics, and the National Cancer Institute. J Clin Invest 1999;104:S15-7.
    • (1999) J Clin Invest , vol.104
    • Klausner, R.D.1
  • 111
    • 0038077566 scopus 로고    scopus 로고
    • NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junction
    • Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junction. Genes Dev 2003;17:1090-1100.
    • (2003) Genes Dev , vol.17 , pp. 1090-1100
    • Lallemand, D.1    Curto, M.2    Saotome, I.3    Giovannini, M.4    McClatchey, A.I.5
  • 112
    • 24044521938 scopus 로고    scopus 로고
    • The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity
    • Ryu CH, Kim SW, Lee KH, et al. The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity. Oncogene 2005;24:5355-64.
    • (2005) Oncogene , vol.24 , pp. 5355-5364
    • Ryu, C.H.1    Kim, S.W.2    Lee, K.H.3
  • 113
    • 16844367763 scopus 로고    scopus 로고
    • The NF2 tumor suppressor Merlin and ERM proteins interact with N-WASP and regulate its actin polymerization function
    • Manchanda N, Lyubimova A, Ho HY, et al. The NF2 tumor suppressor Merlin and ERM proteins interact with N-WASP and regulate its actin polymerization function. J Biol Chem 2005;280:12517-22.
    • (2005) J Biol Chem , vol.280 , pp. 12517-12522
    • Manchanda, N.1    Lyubimova, A.2    Ho, H.Y.3
  • 114
    • 15744403726 scopus 로고    scopus 로고
    • Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells
    • Rangwala R, Banine F, Borg JP, Sherman LS. Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. J Biol Chem 2005;280:11790-7.
    • (2005) J Biol Chem , vol.280 , pp. 11790-11797
    • Rangwala, R.1    Banine, F.2    Borg, J.P.3    Sherman, L.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.