The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the 'open' conformation and suppresses cell growth and motility

Human Molecular Genetics

Volumn 10, Issue 8, 2001, Pages 825-834

  Gutmann, David H ^a   Haipek, Carrie A ^a   Burke, Stephen P ^a   Sun, Chun Xiao ^a   Scoles, Daniel R ^b   Pulst, Stefan M ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERLIN; PROTEIN TYROSINE KINASE; SCATTER FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL MOTILITY; CELL SPREADING; CONFORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; GENE ACTIVITY; GENE MAPPING; GENE OVEREXPRESSION; GROWTH INHIBITION; GROWTH REGULATION; NEURILEMOMA; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RAT; TUMOR SUPPRESSOR GENE;

ANIMALIA; FALCO COLUMBARIUS;

EID: 0035311373     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.8.825     Document Type: Article

References (39)

1. A genetic study of type 2 neurofibromatosis in the United Kingdom. II. Guidelines for genetic counseling
2. Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas
3. Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors
4. Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas
5. The neurofibromatosis type 2 gene is inactivated in schwannomas
6. Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas
7. Reduced expression of schwannomin/merlin in human sporadic meningiomas
8. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas
9. Defects in neurofibromatosis 2 protein function can arise at multiple levels
10. Interdomain binding mediates tumor growth suppression by the NF2 gene product
11. Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer
12. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
13. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
14. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
15. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
16. Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins
17. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
18. Molecular dissection of radixin: Distinct and interdependent functions of the amino- and carboxyterminal domains
19. Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations
20. Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin
21. Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF
22. Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading
23. The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells
24. Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells
25. Ruffling membrane, stress fiber, cell spreading, and proliferation abnormalities in human schwannoma cells
26. Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins
27. + exchange, is a common interactor for merlin and ERM (MERM) proteins
28. The neurofibromatosis 2 gene product schwannomin interacts with beta-II-spectrin
29. The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate
30. Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas
31. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
32. CD44 acts as both a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor
33. Merlin differentially associates with the microtubule and actin cytoskeleton
34. Neurofibromatosis 2 tumor suppressor protein co-localizes with ezrin and CD44 and associates with actin-containing cytoskeleton
35. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
36. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimulation
37. Enhanced transformation by a plasma membrane-associated met oncoprotein: Activation of a phosphoinositide 3′-kinase-dependent autocrine loop involving hyaluronic acid and CD44
38. Regulation of endothelial CD44 expression and endothelium-tumour cell interactions by hepatocyte growth factor/scatter factor
39. Heparin sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met