Transfection of Smac sensitizes tumor cells to etoposide-induced apoptosis and eradicates established human hepatoma in vivo

Cancer Gene Therapy

Volumn 13, Issue 4, 2006, Pages 420-427

  Zhao, J ^a   Jin, J ^a   Zhang, X ^a   Shi, M ^a   Dai, J ^a   Wu, M ^a   Wang, R ^a   Guo, Y ^a,b  

^a Key Laboratory of Arrhythmias of Ministry of Education   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; Mitochondria; p53; Smac

Indexed keywords

ANTINEOPLASTIC AGENT; ETOPOSIDE; FLUOROURACIL; PROTEIN ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER THERAPY; CELL PROTECTION; CELL STRAIN; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG POTENCY; DRUG SENSITIZATION; FEMALE; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MITOCHONDRION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; TUMOR CELL; TUMOR XENOGRAFT; VIRAL GENE THERAPY;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BONE NEOPLASMS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; ETOPOSIDE; FEMALE; FLUOROURACIL; GENE THERAPY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIAL PROTEINS; OSTEOSARCOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

ADENOVIRIDAE; ANIMALIA;

EID: 33645021667     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700910     Document Type: Article

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