Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase λ

Nucleic Acids Research

Volumn 34, Issue 5, 2006, Pages 1405-1415

  Maga, Giovanni ^a,b,d   Shevelev, Igor ^b   Villani, Giuseppe ^c   Spadari, Silvio ^a   Hübscher, Ulrich ^b  

^a CNR   (Italy)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^d NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE LAMBDA; MAGNESIUM; MANGANESE; PRIMER DNA; REPLICATION PROTEIN A; RIBONUCLEOTIDE; UNCLASSIFIED DRUG; DEOXYRIBONUCLEOTIDE; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE BETA2; RPA1 PROTEIN, HUMAN;

ARTICLE; BASE MISPAIRING; DNA TEMPLATE; ENZYME ACTIVITY; ENZYME REPRESSION; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; HUMAN; IN VITRO STUDY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS; STEADY STATE; CHEMISTRY; METABOLISM; PHYSIOLOGY;

BASE PAIR MISMATCH; DEOXYRIBONUCLEOTIDES; DNA POLYMERASE BETA; HUMANS; MAGNESIUM; MANGANESE; PHENOTYPE; PROLIFERATING CELL NUCLEAR ANTIGEN; REPLICATION PROTEIN A; RIBONUCLEOTIDES; TEMPLATES, GENETIC;

EID: 33645010625     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl032     Document Type: Article

References (35)

1. Hubscher,U., Maga,G. and Spadari,S. (2002) Eukaryotic DNA polymerases. Aunu Rev. Biochem., 71, 133-163.
2. Garcia-Diaz,M., Dominguez,O., Lopez-Fernandez,L.A., de Lera,L.T., Saniger,M.L., Ruiz,J.F., Parraga,M., Garcia-Ortiz,M.J., Kirchhoff,T., del Mazo,J. et al. (2000) DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. J. Mol. Biol., 301, 851-867.
3. Ramadan,K., Shevelev,I. and Hubscher,U. (2004) The DNA-polymerase-X family: Controllers of DNA quality? Nat. Rev. Mol. Cell Biol., 5, 1038-1043.
4. Maga,G., Villani,G., Ramadan,K., Shevelev,I., Le Gac,N.T., Blanco,L., Blanca,G., Spadari,S. and Hubscher,U. (2002) Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. J. Biol. Chem., 277, 48434-48440.
5. Maga,G., Blanca,G., Shevelev,I., Frouin,I., Ramadan,K., Spadari,S., Villani,G. and Hubscher,U. (2004) The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. Faseb J., 18, 1743-1745.
6. Lee,J.W., Blanco,L., Zhou,T., Garcia-Diaz,M., Bebenek,K., Kunkel,T.A., Wang,Z. and Povirk,L.F. (2004) Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J. Biol. Chem., 279, 805-811.
7. Ma,Y., Lu,H., Tippin,B., Goodman,M.F., Shimazaki,N., Koiwai,O., Hsieh,C.L., Schwarz,K. and Lieber,M.R. (2004) A biochemically defined system for mammalian nonhomologous DNA end joining. Mol. Cell, 16, 701-713.
8. McElhinny,S.A., Havener,J.M., Garcia-Diaz,M., Juarez,R., Bebenek,K., Kee,B.L., Blanco,L., Kunkel,T.A. and Ramsden,D.A. (2005) A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol. Cell, 19, 357-366.
9. DeRose,E.F., Kirby,T.W., Mueller,G.A., Bebenek,K., Garcia-Diaz,M., Blanco,L., Kunkel,T.A. and London,R.E. (2003) Solution structure of the lyase domain of human DNA polymerase lambda. Biochemistry, 42, 9564-9574.
10. Garcia-Diaz,M., Bebenek,K., Krahn,J.M., Blanco,L., Kunkel,T.A. and Pedersen,L.C. (2004) A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Mol. Cell, 13, 561-572.
11. Blanca,G., Shevelev,I., Ramadan,K., Villani,G., Spadari,S., Hubscher,U. and Maga,G. (2003) Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: A kinetic and thermodynamic study. Biochemistry, 42, 7467-7476.
12. Ramadan,K., Shevelev,I.V., Maga,G. and Hubscher,U. (2002) DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. J. Biol. Chem., 277, 18454-18458.
13. Fiala,K.A., Abdel-Gawad,W. and Suo,Z. (2004) Pre-steady-state kinetic studies of the fidelity and mechanism of polymerization catalyzed by truncated human DNA polymerase lambda. Biochemistry, 43, 6751-6762.
14. Werneburg,B.G., Ahn,J., Zhong,X., Hondal,R.J., Kraynov,V.S. and Tsai,M.D. (1996) DNA polymerase beta: Pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity. Biochemistry, 35, 7041-7050.
15. Roettger,M.P., Fiala,K.A., Sompalli,S., Dong,Y. and Suo,Z. (2004) Pre-steady-state kinetic studies of the fidelity of human DNA polymerase mu. Biochemistry, 43, 13827-13838.
16. Bebenek,K., Garcia-Diaz,M., Blanco,L. and Kunkel,T.A. (2003) The frameshift infidelity of human DNA polymerase lambda. Implications for function. J. Biol. Chem., 278, 34685-34690.
17. Blanca,G., Villani,G., Shevelev,I., Ramadan,K., Spadari,S., Hubscher,U. and Maga,G. (2004) Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry, 43, 11605-11615.
18. Maga,G., Ramadan,K., Locatelli,G.A., Shevelev,I., Spadari,S. and Hubscher,U. (2005) DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. J. Biol. Chem., 280, 1971-1981.
19. Shevelev,I., Blanca,G., Villani,G., Ramadan,K., Spadari,S., Hubscher,U. and Maga,G. (2003) Mutagenesis of human DNA polymerase lambda: Essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucleic Acids Res., 31, 6916-6925.
20. Jonsson,Z.O., Hindges,R. and Hübscher,U. (1998) Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. EMBO J., 17, 2412-2425.
21. Henricksen,L.A., Umbricht,C.B. and Wold,M.S. (1994) Recombinant replication protein A: Expression, complex formation, and functional characterization. J. Biol. Chem., 269, 11121-11132.
22. Malecki,E.A., Devenyi,A.G., Beard,J.L. and Connor,J.R. (1999) Existing and emerging mechanisms for transport of iron and manganese to the brain. J. Neurosci. Res., 56, 113-122.
23. Bergoglio,V., Ferrari,E., Hubscher,U., Cazaux,C. and Hoffmann,J.S. (2003) DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. J. Mol. Biol., 331, 1017-10123.
24. Ruiz,J.F., Juarez,R., Garcia-Diaz,M., Terrados,G., Picher,A.J., Gonzalez-Barrera,S., Fernandez de Henestrosa,A.R. and Blanco,L. (2003) Lack of sugar discrimination by human Pol mu requires a single glycine residue. Nucleic Acids Res., 31, 4441-4449.
25. Vaisman,A., Ling,H., Woodgate,R. and Yang,W. (2005) Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J., 24, 2957-2967.
26. Mozzherin,D.J., McConnell,M., Jasko,M.V., Krayevsky,A.A., Tan,C.K., Downey,K.M. and Fisher,P.A. (1996) Proliferating cell nuclear antigen promotes misincorporation catalyzed by calf thymus DNA polymerase S. J. Biol. Chem., 271, 31711-31717.
27. Mozzherin,D.J., Shibutani,S., Tan,C.K., Downey,K.M. and Fisher,P.A. (1997) Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase δ. Proc. Natl Acad. Sci. USA, 94, 6126-6131.
28. Haracska,L., Johnson,R.E., Unk,I., Phillips,B., Hurwitz,J., Prakash,L. and Prakash,S. (2001) Physical and functional interactions of human DNA polymerase eta with PCNA. Mol. Cell Biol., 21, 7199-7206.
29. Haracska,L., Johnson,R.E., Unk,I., Phillips,B.B., Hurwitz,J., Prakash,L. and Prakash,S. (2001) Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc. Natl Acad. Sci. USA, 98, 14256-14261.
30. Haracska,L., Unk,I., Johnson,R.E., Phillips,B.B., Hurwitz,J., Prakash,L. and Prakash,S. (2002) Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol. Cell Biol., 22, 784-791.
31. Maga,G., Frouin,I., Spadari,S. and Hübscher,U. (2001) RP-A as a fidelity clamp for DNA polymerase α. J. Biol. Chem., 276, 18235-18242.
32. Ma,Y., Lu,H., Schwarz,K. and Lieber,M.R. (2005) Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model. Cell Cycle, 4, 1193-1200.
33. Perrault,R., Cheong,N., Wang,H. and Iliakis,G. (2001) RPA facilitates rejoining of DNA double-strand breaks in an in vitro assay utilizing genomic DNA as substrate. Int. J. Radiat. Biol., 77, 593-607.
34. Braithwaite,E.K., Kedar,P.S., Lan,L., Polosina,Y.Y., Asagoshi,K., Poltoratsky,V.P., Horton,J.K., Miller,H., Teebor,G.W. et al. (2005) DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J. Biol. Chem., 280, 31641-31647.
35. Braithwaite,E.K., Prasad,R., Shock,D.D., Hou,E.W., Beard,W.A. and Wilson,S.H. (2005) DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. J. Biol. Chem., 280, 18469-18475.