Mutagenesis of human DNA polymerase λ: Essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities

Nucleic Acids Research

Volumn 31, Issue 23, 2003, Pages 6916-6925

  Shevelev, Igor ^c   Blanca, Giuseppina ^a   Villani, Giuseppe ^b   Ramadan, Kristijan ^c   Spadari, Silvio ^a   Hübscher, Ulrich ^c   Maga, Giovanni ^a  

^a CNR   (Italy)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; DNA; DNA DIRECTED DNA POLYMERASE DELTA; GLYCINE; PHENYLALANINE; POL PROTEIN; TRANSFERASE; TYROSINE;

ACCURACY; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; GENE MUTATION; HUMAN; MOLECULAR MODEL; MUTAGENESIS; NUCLEOTIDE BINDING SITE; PREDICTION; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; DNA POLYMERASE BETA; DNA REPLICATION; HUMANS; KINETICS; MULTIENZYME COMPLEXES; MUTAGENESIS; MUTATION; PURINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344668821     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg896     Document Type: Article

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