The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue

Diabetes/Metabolism Research and Reviews

Volumn 22, Issue 2, 2006, Pages 146-154

  Klöting, Nora ^a   Blüher, Matthias ^b   Klöting, Ingrid ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Foxo1; IL6; Insulin resistance; Metabolic syndrome; Ppar

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN; FATTY ACID SYNTHASE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR FKHR;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EPIDIDYMIS FAT; GENE EXPRESSION; GENETIC ANALYSIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HISTOPATHOLOGY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; MALE; METABOLIC SYNDROME X; MULTIFACTORIAL INHERITANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RAT STRAIN; SUBCUTANEOUS FAT;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL TRANSPORT; CARBON DIOXIDE; DNA PRIMERS; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN RESISTANCE; LACTATES; MALE; METABOLIC SYNDROME X; PHENOTYPE; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; TRIGLYCERIDES;

EID: 33644990604     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.582     Document Type: Article

References (32)

1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complication. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med 1998; 15: 539-553.
2. Clement K, Boutin P, Froguel P. Genetics of obesity. Am J Pharmacogenomics 2002; 2: 177-187.
3. Groop L, Orho-Melander M. The dysmetabolic syndrome. J Intern Med 2001; 250: 105-120.
4. Unger RH, Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 2001; 15: 312-321.
5. van den Brandt J, Kovacs P, Klöting I. Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg (RT1u Haplotype) rat. Metabolism 2000; 49: 1140-1144.
6. van den Brandt J, Kovacs P, Klöting I. Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats. Int J Obes Relat Metab Disord 2002; 26: 573-576.
7. van den Brandt J, Kovacs P, Klöting I. Metabolic features in disease-resistant as well as in hypertensive SHR and newly established obese Wistar Ottawa Karlsburg inbred rats. Int J Obes Relat Metab Disord 2000; 24: 1618-1622.
8. Klöting I, Kovacs P, van den Brandt J. Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats. Biochem Biophys Res Commun 2001; 284: 1618-1622.
9. Kovacs P, van den Brandt J, Klöting I. Genetic dissection of the syndrome X in the rat. Biochem Biophys Res Commun 2000; 269: 600-605.
10. Lebovitz HE. The relationship of obesity to the metabolic syndrome. Int J Clin Pract Suppl 2003; 134: 18-27.
11. van den Brandt J, Kovacs P, Kloting I. Metabolic variability among disease-resistant inbred rat strains and in comparison with wild rats (Rattus norvegicus). Clin Exp Pharmacol Physiol 2000: 27: 793-795.
12. Klöting I, Vogt L. BB/O(ttawa) K(arlsburg) rats. Features of a subline of diabetes-prone BB rats. Diabetes Res 1991; 18: 79-87.
13. Blüher M, Michael MD, Peroni OD, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002; 2: 25-38.
14. Tozzo E, Shepherd PR, Gnudi L, et al. Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. Am J Physiol 1995; 268: E956-E964.
15. Jansson PA, Larsson A, Smith U, et al. Lactate release from the subcutaneous tissue in lean and obese men. J Clin Invest 1994; 93: 240-246.
16. James DE, Burleigh KM, Kraegen EW. Time dependence of insulin action in muscle and adipose tissue in the rat in vivo. An increasing response in adipose tissue with time. Diabetes 1985; 34: 1049-1054.
17. Joffe BI, Panz VR, Raal FJ. From lipodystrophy syndromes to diabetes mellitus. Lancet 2001; 357: 1379-1381.
18. Abel ED, Peroni OD, Kim JK, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001; 409: 729-733.
19. Funakoshi A, Miyasaka K, Shinozaki H, et al. An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. Biochem Biophys Res Commun 1995; 210: 787-796.
20. Fernandez-Real JM, Broch M, Vendrell J, et al. Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 2000; 49: 517-520.
21. Bruun JM, Lihn AS, Verdich C, et al. Regulation of adiponectin tissue-derived cytokines: in vivo and in vitro Investigations in Humans. Am J Physiol Endocrinol Metab 2003; 285: E527-E533.
22. Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinaemia. J Clin Endocrinol Metab 2001; 86: 1930-1935.
23. Rask E, Olsson T, Sodenberg S, et al. Tissue-specific changes dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 2001; 86: 1418-1421.
24. Steward PM, Boulton A, Kumar S, et al. Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999; 84: 1022-1027.
25. Wake JD, Rask E, Livingstone DEW, et al. Local and systemic impact of transcriptional up-regulation of 11β-Hydroxysteroid dehydrogenase Type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 2003; 88: 3983-3988.
26. Lefebvre AM, Laville M, Vega N, et al. Depot-specific differences in adipose tissue gene expression in lean and obese subjects. J Clin Invest 1998; 100: 2416-2422.
27. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, et al. Peroxisome proliferations-activated receptor gene expression in human tissue. Effects of obesity, weight loss and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99: 2416-2422.
28. Kitamura T, Nakae J, Kitamura Y, et al. The forkhead transcription factor Foxo1 links insulin signalling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002; 110: 1839-1847.
29. Nakae J, Kitamura T, Kitamura Y, et al. The forkhead transcription factor foxo1 regulates adipocytes differentiation. Dev Cell 2003; 4: 119-129.
30. Nakae J, Kitamura T, Silver DL, et al. The forkhead transcription factor Foxo1 (Fkhr) counters insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 2001; 108: 1359-1367.
31. Berger J, Biswas C, Vicario P, et al. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature 1998; 340: 70-72.
32. Garvey WT, Maianu L, Huecksteadt TP, et al. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J Clin Invest 1991; 87: 1072-1081.