Metabolomics as a diagnostic tool for hepatology: Validation in a naturally occurring canine model

Metabolomics

Volumn 1, Issue 3, 2005, Pages 215-225

  Whitfield, Phillip David ^a   Noble, Peter John Mantyla ^a   Major, Hilary ^b   Beynon, Robert Jeffrey ^a   Burrow, Rachel ^a   Freeman, Alistair Iain ^a   German, Alexander James ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b WATERS CORPORATION   (United States)

Author keywords

Dogs; Hepatopathy; Liver; Mass spectrometry; Metabonomics; Portovascular anomalies

Indexed keywords

CANIS FAMILIARIS; EQUIDAE;

EID: 33644973725     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-005-0001-3     Document Type: Article

References (27)

1. Allen, J., Davey, H.M., Broadhurst, D., et al. (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat. Biotechnol. 21, 92-696
2. Brindle, J.T., Antti, H., Holmes, E., et al. (2002) Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1 H-NMR-based metabolomics. Nat. Med. 8, 1439-1444
3. Center, S.A. (1996) Hepatic vascular diseases in Guilford, W.G., Center, S.A., Strombeck, D.R., Williams, D.A. and Meyer, D.J. (Eds), Strombeck's Small Animal Gastroenterology, 3rd edn. WB Saunders, Philadelphia, pp. 802-846
4. Dunn, W.B., Bailey, N.J. and Johnson, H.E. (2005) Measuring the metabolome: Current analytical technologies. Analyst 130, 606-625
5. Fang, N., Yu, S. and Badger, T.M. (2003) LC-MS/MS analysis of lysophospholipids associated with soy protein isolate. J. Agric. Food Chem. 51, 6676-6682
6. German, J.B., Roberts, M.A. and Watkins, S.M. (2003) Genomics and metabolomics as markers for the interaction of diet and health: Lessons from lipids. J. Nutr. 133, 2078S-2083S
7. Griffin, J.L. (2003) Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis. Curr. Opin. Chem. Biol. 7, 648-654
8. Griffin, J.L. and Shockcor, J.P. (2004) Metabolic profiles of cancer cells. Nat. Rev. Cancer 7, 551-561
9. Lamers, R.J., DeGroot, J., Spies-Farber, E.J., et al. (2003) Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs. J. Nutr. 133, 1776-1780
10. Lehmann, W.D., Koester, M., Erben, G. and Keppler, D. (1997) Characterization and quantification of rat bile phosphatidylcholine by electrospray-tandem mass spectrometry. Anal. Biochem. 246, 102-110
11. Lenz, E.M., Bright, J., Knight, R., Wilson, I.D. and Major, H. (2004a). A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using (1)H NMR and HPLC-TOF/MS: Time dependant changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity. Analyst 129, 535-541
12. Lenz, E.M., Bright, J., Knight, R., Wilson, I.D. and Major, H. (2004b) Cyclosporin A-induced changes in endogenous metabolites in rat urine: A metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/ MS and chemometrics. J. Pharm. Biomed. Anal. 35, 599-608
13. Lindon, J.C., Nicholson, J.K., Holmes, E., et al. (2003). The role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol. Appl. Pharmacol. 187, 137-146
14. Mills, K.A., Mustaq, I., Johnson, A.W., Whitfield, P.D. and Clayton, P.T. (1998) A method for the quantitation of conjugated bile acids in dried blood spots using electrospray ionization-tandem mass spectrometry. Pediatr. Res. 43, 361-368
15. Mustaq, I., Logan, S., Morris, M., et al. (1999) Screening of newborn infants for cholestatic hepatobilary disease with tandem mass spectrometry. Brit. Med. J. 319, 471-477
16. Nicholson, J.K., Connelly, J., Lindon, J.C. and Holmes, E. (2002). Metabonomics: A platform for studying drug toxicity and gene function. Nat. Rev. Drug Discov. 1, 153-161
17. Nicholsonm, J.K. and Wilson, I.D. (2003) Understanding 'global' systems biology: Metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2, 668-676
18. Plumb, R.S., Stumpf, C.L., Granger, J.H., Castro-Perez, J., Haselden, J.N. and Dear, G.J. (2003). Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids. Rapid Commun. Mass Spectrom. 17, 2632-2638
19. Raamsdonk, L.M., Teusink, B., Broadhurst, D., et al. (2000). A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 19, 45-50
20. Roessner, U., Luedemann, A., Brust, D., et al. (2001) Metabolite profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell. 13, 11-29
21. Rosado, B. and Kamath, P.S. (2003). Transjugular intrahepatic portosystemic shunts: An update. Liver Transpl. 9, 207-217
22. Schafer, K., Ukida, M., Steffen, C., Bode, C., Zelder, O. and Bode, J.C. (1985) Effect of ammonia on plasma and cerebrospinal amino acids in dogs with and without portacaval anastomoses. Res. Exp. Med. 185, 35-44
23. Wang, Y., Holmes, E., Nicholson, J.K., et al. (2004). Metabonomic investigations in mice infected with Schistosoma mansoni: An approach for biomarker identification. Proc. Natl. Acad. Sci. USA 101, 12676-12681
24. Watanabe, A. (2000). Portal-systemic encephalopathy in non-cirrhotic patients: Classification of clinical types, diagnosis and treatment. J. Gastroenterol. Hepatol. 15, 969-979
25. Waters, N.J., Holmes, E., Waterfield, C.J., Farrant, R.D. and Nicholson, J.K. (2002). NMR and pattern recognition studies on liver extracts and in livers from rats treated with alpha-naphthylisothiocyanate. Biochem. Pharmacol. 64, 67-77
26. Wilson, I.D., Plumb, R., Granger, J., Major, H., Williams, R. and Lenz, E.M. (2005). HPLC-MS-based methods for the study of metabonomics. J. Chromatogr. B 817, 67-76
27. Yang, J., Xu, G., Zheng, et al. (2004). Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitisis and hepatocirrhosis diseases. J. Chromatogr. B 813, 59-65