Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 9, 2006, Pages 3199-3209

  Tachi, Yukihiro ^a   Dai, Wei Min ^b   Tanabe, Kazuhito ^a   Nishimoto, Sei Ichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Allylic rearrangement; DNA cleavage; Enediyne; Prodrug; UV irradiation

Indexed keywords

3 ACETOXY 4 (2' HYDROXY 1' PHENYLETHYLIDENE)CYCLODECA 1,5 DIYNE; 3 ACETOXY 4 [2' (TERT BUTYLDIMETHYLSILYLOXY) 1' PHENYLETHYLIDENE]CYCLODECA 1,5 DIYNE; 4 (2' HYDROXY 1' PHENYLETHYLIDENE) 3 (METHOXYACETOXY)CYCLODECA 1,5 DIYNE; 4 [2' (TERT BUTYLDIMETHYLSILYLOXY) 1' PHENYLETHYLIDENE] 3 (METHOXYACETOXY)CYCLODECA 1,5 DIYNE; 4 [2' (TERT BUTYLDIMETHYLSILYLOXY) 1' PHENYLETHYLIDENE]CYCLODECA 1,5 DIYN 3 OL; ALKENE; BASE; BUFFER; CIRCULAR DNA; EPOXIDE; EXOCYCLIC DOUBLE BOND; PRODRUG; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ALLYLIC REARRANGEMENT; ARTICLE; DNA CLEAVAGE; DNA SUPERCOILING; DRUG SYNTHESIS; ISOMERIZATION; SONOGASHIRA REACTION; ULTRAVIOLET RADIATION;

AMINO ACIDS, CYCLIC; DNA; IONS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PRODRUGS; ULTRAVIOLET RAYS;

EID: 33644969545     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.040     Document Type: Article

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