Natural product inspired design of enediyne prodrugs via rearrangement of an allylic double bond

Current Medicinal Chemistry

Volumn 10, Issue 21, 2003, Pages 2265-2283

  Dai, Wei Min ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Allylic; Cytotoxicity; Diradical; DNA; Enediyne; Prodrug; Rearrangement

Indexed keywords

3 ACYCLO 4 METHYLIDENE 1,5 DIYNE; 3 HYDROXY 4 (PHENYLMETHYLIDENE)CYCLODECA 1,5 DIYNE DERIVATIVE; 3 METHOXYACETATE 4 (PHENYLMETHYLIDENE)CYCLODECA 1,5 DIYNE; ALKENYLDIALKYNE DERIVATIVE; ANTHRAQUINONE DERIVATIVE; ANTIBIOTIC AGENT; ANTIBIOTIC C 1027; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; CALICHEAMICIN DERIVATIVE; CALICHEAMICIN GAMMA1; CYCLODECA 1,5 DYN 3 ENE DERIVATIVE; DNA; DYNEMICIN A; ESPERAMICIN; ESPERAMICIN A1; KEDARCIDIN; MADUROPEPTIN; NAMENAMICIN; PRODRUG; QUINONE DERIVATIVE; SHISHIJIMICIN A; UNCLASSIFIED DRUG; ZINOSTATIN;

ALLYLIC REARRANGEMENT; ANTINEOPLASTIC ACTIVITY; CANCER CELL CULTURE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CYTOTOXICITY; DNA CLEAVAGE; DRUG DESIGN; DRUG HALF LIFE; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA P 388 CELL; MASS SPECTROMETRY; REACTION ANALYSIS; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0141919494     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033456756     Document Type: Review

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