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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2861-2864

Azinomycin inspired bisepoxides: Influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking

(5) LePla, Rachel C a,d Landreau, Cyrille A S a Shipman, Michael a Hartley, John A b Jones, George D D c

a UNIVERSITY OF WARWICK (United Kingdom)

b UNIVERSITY COLLEGE LONDON (United Kingdom)

c UNIVERSITY OF LEICESTER (United Kingdom)

d UNIVERSITY OF LEICESTER (United Kingdom)

Author keywords

Anti cancer; DNA alkylation; Epoxides; Interstrand cross linking

Indexed keywords

ANTINEOPLASTIC AGENT; AZINOMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA CROSS LINKING; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ANALYSIS; TUMOR CELL;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPOXY COMPOUNDS; GLYCOPEPTIDES; HUMANS; NAPHTHALENES; PEPTIDES;

EID: 19544369505 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.03.091 Document Type: Article

Times cited : (23)

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- Three additional 15-mer oligonucleotide duplexes were studied under the same conditions reported in Table 1. In each case, the duplex was constructed from the same unreactive A-T sequence with modifications being made to the central triplet sequence. Specifically, the sequences studied were: 5′-d(GTC)-3′/3′-d(CAG)-5′ (8); 5′-d(GCT)-3′/ 3′-d(CGA)-5′ (9); 5′-d(GTT)-3′/3′-d(CAA)-5′ (10). 3a, 3b and 3f produced measurable amounts of ISC formation (10%, 14% and 70%, respectively) with duplex 8. However, only 3f produced measurable amounts of ISC (30% and 21%, respectively) with duplexes 9 and 10

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