Challenges facing the biologist doing chemical genetics

Nature Chemical Biology

Volumn 2, Issue 2, 2006, Pages 55-58

  Soderholm, Jon ^a   Uehara Bingen, Mike ^b   Weis, Karsten ^a   Heald, Rebecca ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT; PROTEIN; PROTEIN INHIBITOR;

BIOLOGY; CHEMICAL GENETICS; HIGH THROUGHPUT SCREENING; MOLECULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SCIENCE; ARTICLE; BIOASSAY; CHEMISTRY; COMPUTER PROGRAM; DRUG DESIGN; DRUG SCREENING; MOLECULAR BIOLOGY;

BIOLOGICAL ASSAY; CHEMISTRY; COMPUTATIONAL BIOLOGY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MOLECULAR BIOLOGY; SOFTWARE;

EID: 33644931663     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio0206-55     Document Type: Review

References (29)

1. Hung, D.T., Jamison, T.F. & Schreiber, S.L. Chem. Biol. 3, 623-639 (1996).
2. Crews, C.M. & Shotwell, J.B. Prog. Cell Cycle Res. 5, 125-133 (2003).
3. Tamura, G., Ando, K., Suzuki, S., Takatsuki, A. & Arima, K. J. Antibiot. (Tokyo) 21, 160-161 (1968).
4. Horakova, K. & Betina, V. Neoplasma 24, 21-27 (1977).
5. Betina, V. & Micekova, D. Z. Allg. Mikrobiol. 12, 355-364 (1972).
6. Wani, M.C., Taylor, H.L., Wall, M.E., Coggon, P. & McPhail, A.T. J. Am. Chem. Soc. 93, 2325-2327 (1971).
7. Zhang, J.H., Chung, T.D. & Oldenburg, K.R. J. Biomol. Screen. 4, 67-73 (1999).
8. Mitchison, T.J. Chembiochem. 6, 33-39 (2005).
9. Wignall, S.M. et al. Chem. Biol. 11, 135-146 (2004).
10. Luesch, H. et al. Chem. Biol. 12, 55-63 (2005).
11. Mayer, T.U. et al. Science 286, 971-974 (1999).
12. Yarrow, J.C., Totsukawa, G., Charras, G.T. & Mitchison, T.J. Chem. Biol. 12, 385-395 (2005).
13. Schneider, G. & Fechner, U. Nat. Rev. Drug Discov. 4, 649-663 (2005).
14. Gadek, T.R. & Nicholas, J.B. Biochem. Pharmacol. 65, 1-8 (2003).
15. Chang, Y.T. et al. Chem. Biol. 6, 361-375 (1999).
16. Halpin, D.R. & Harbury, P.B. PLoS Biol. 2, E174 (2004).
17. Gartner, Z.J. et al. Science 305, 1601-1605 (2004).
18. Erlanson, D.A., Wells, J.A. & Braisted, A.C. Annu. Rev. Biophys. Biomol. Struct. 33, 199-223 (2004).
19. Cousins, G.R., Poulsen, S.A. & Sanders, J.K. Curr. Opin. Chem. Biol. 4, 270-279 (2000).
20. Lam, R.T. et al. Science 308, 667-669 (2005).
21. Becattini, B. & Pellecchia, M. Chemistry (2005).
22. Kitchen, D.B., Decornez, H., Furr, J.R. & Bajorath, J. Nat. Rev. Drug Discov. 3, 935-949 (2004).
23. Kuntz, I.D. Science 257, 1078-1082 (1992).
24. Jain, A.N. J. Med. Chem. 46, 499-511 (2003).
25. Irwin, J.J. & Shoichet, B.K. J. Chem. Inf. Model. 45, 177-182 (2005).
26. McGovern, S.L., Helfand, B.T., Feng, B. & Shoichet, B.K. J. Med. Chem. 46, 4265-4272 (2003).
27. Feng, B., Shelat, A., Thompson, N.D., Guy, R.K. & Shoichet, B.K. Nat. Chem. Biol. 1, 146-148 (2005).
28. Turek-Etienne, T.C. et al. J. Biomol. Screen. 8, 176-184 (2003).
29. Banks, P., Gosselin, M. & Prystay, L. J. Biomol. Screen. 5, 329-334 (2000).