Modulation of immunity-related gene expression in small intestines of mice by oral administration of lactoferrin

Clinical and Vaccine Immunology

Volumn 13, Issue 2, 2006, Pages 239-245

  Wakabayashi, Hiroyuki ^a   Takakura, Natsuko ^a   Yamauchi, Koji ^a   Tamura, Yoshitaka ^a  

^a MORINAGA MILK INDUSTRY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; BOVINE SERUM ALBUMIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; LACTOFERRIN; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOREGULATION; INFECTION; INFECTION PREVENTION; LEUKOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; SPLEEN;

ADMINISTRATION, ORAL; ANIMALS; BASE SEQUENCE; CYTOKINES; DNA PRIMERS; FEMALE; GENE EXPRESSION; IMMUNOLOGIC FACTORS; INTERFERON TYPE II; INTERFERON-BETA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTESTINE, SMALL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTOFERRIN; MICE; MICE, INBRED BALB C; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERUM ALBUMIN, BOVINE;

EID: 33644913949     PISSN: 15566811     EISSN: None     Source Type: Journal    
DOI: 10.1128/CVI.13.2.239-245.2006     Document Type: Article

References (38)

1. Baveye, S., E. Elass, J. Mazurier, G. Spik, and D. Legrand. 1999. Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin. Chem. Lab. Med. 37:281-286.
2. Bhimani, R. S., Y. Vendrov, and P. Furmanski. 1999. Influence of lactoferrin feeding and injection against systemic staphylococcal infections in mice. J. Appl. Microbiol. 86:135-144.
3. Chierici, R. 2001. Antimicrobial actions of lactoferrin. Adv. Nutr. Res. 10:247-269.
4. Haversen, L. A., I. Engberg, L. Baltzer, G. Dolphin, L. A. Hanson, and I. Mattsby-Baltzer. 2000. Human lactoferrin and peptides derived from surface-exposed helical region reduce experimental Escherichia coli urinary tract infection in mice. Infect. Immun. 68:5816-5823.
5. Hugot, J. P., M. Chamaillard, H. Zouali, S. Lesage, J. P. Cezard, J. Belaiche, S. Almer, C. Tysk, C. A. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J. F. Colombel, M. Sahbatou, and G. Thomas. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603.
6. Iigo, M., M. Shimamura, E. Matsuda, K. Fujita, H. Nomoto, J. Satoh, S. Kojima, D. B. Alexander, M. A. Moore, and H. Tsuda. 2004. Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine 25:36-44.
7. Isamida, T., T. Tanaka, Y. Omata, K. Yamauchi, K. Shimazaki, and A. Saito. 1998. Protective effects of lactoferricin against Toxoplasma gondii infection in mice. J. Vet. Med. Sci. 60:241-244.
8. Iwasa, M., M. Kaito, J. Ikoma, M. Takeo, I. Imoto, Y. Adachi, K. Yamauchi, R. Koizumi, and S. Teraguchi. 2002. Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HGV genotype 1b. Am. J. Gastroenterol. 97:766-767.
9. Komiya, T., Y. Tanigawa, and S. Hirohashi. 1998. Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice. Biochem. Biophys. Res. Commun. 251:759-762.
10. Kuhara, T., M. Iigo, T. Itoh, Y. Ushida, K. Sekine, N. Terada, H. Okamura, and H. Tsuda. 2000. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr. Cancer 38:192-199.
11. Kuwata, H., T.-T. Yip, K. Yamauchi, S. Teraguchi, H. Hayasawa, M. Tomita, and T. W. Hutchens. 1998. The survival of ingested lactoferrin in the gastrointestinal tract of adult mice. Biochem. J. 334:321-323.
12. Lala, S., Y. Ogura, C. Osborne, S. Y. Hor, A. Bromfield, S. Davies, O. Ogunbiyi, G. Nuñez, and S. Keshav. 2003. Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 125:47-57.
13. Ogura, Y., D. K. Bonen, N. Inohara, D. L. Nicolae, F. F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, R. H. Duerr, J. P. Achkar, S. R. Brant, T. M. Bayless, B. S. Kirschner, S. B. Hanauer, G. Nuñez, and J. H. Cho. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-606.
14. Oh, S. M., D. H. Hahm, I. H. Kim, and S. Y. Choi. 2001. Human neutrophil lactoferrin trans-activates the matrix metalloproteinase 1 gene through stress-activated MAPK signaling modules. J. Biol. Chem. 276:42575-42579.
15. Oh, S. M., C. W. Pyo, Y. Kim, and S. Y. Choi. 2004. Neutrophil lactoferrin upregulates the human p53 gene through induction of NF-κB activation cascade. Oncogene 23:8282-8291.
16. Ouellette, A. J., D. Darmoul, D. Tran, K. M. Huttner, J. Yuan, and M. E. Selsted. 1999. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell α-defensin. Infect. Immun. 67:6643-6651.
17. Pabst, O., L. Ohl, M. Wendland, M. A. Wurbel, E. Kremmer, B. Malissen, and R. Forster. 2004. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J. Exp. Med. 199:411-416.
18. Salzman, N. H., M. M. Chou, H. de Jong, L. Liu, E. M. Porter, and Y. Paterson. 2003. Enteric Salmonella infection inhibits paneth cell antimicrobial peptide expression. Infect. Immun. 71:1109-1115.
19. Sekine, K., Y. Ushida, T. Kuhara, M. Iigo, H. Baba-Toriyama, M. A. Moore, M. Murakoshi, Y. Satomi, H. Nishino, T. Kakizoe, and H. Tsuda. 1997. Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane. Cancer Lett. 121:211-216.
20. Sfeir, R. M., M. Dubarry, P. N. Boyaka, M. Rautureau, and D. Tomé. 2004. The mode of oral bovine lactoferrin administration influences mucosal and systemic immune responses in mice. J. Nutr. 134:403-409.
21. Shin, K., H. Wakabayashi, K. Yamauchi, S. Teraguchi, Y. Tamura, M. Kurokawa, and K. Shiraki. 2005. Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice. J. Med. Microbiol. 54:717-723.
22. Son, K. N., J. Park, C. K. Chung, D. K. Chung, D. Y. Yu, K. K. Lee, and J. Kim. 2002. Human lactoferrin activates transcription of IL-1β gene in mammalian cells. Biochem. Biophys. Res. Commun. 290:236-241.
23. Suzuki, Y., K. Shin, and B. Lönnerdal. 2001. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry 40:15771-15779.
24. Takakura, N., H. Wakabayashi, H. Ishibashi, S. Teraguchi, Y. Tamura, H. Yamaguchi, and S. Abe. 2003. Oral lactoferrin treatment of experimental oral candidiasis in mice. Antimicrob. Agents Chemother. 47:2619-2623.
25. Takakura, N., H. Wakabayashi, H. Ishibashi, K. Yamauchi, S. Teraguchi, Y. Tamura, H. Yamaguchi, and S. Abe. 2004. Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model. J. Med. Microbiol. 54:495-500.
26. Tanaka, K., M. Ikeda, A. Nozaki, N. Kato, H. Tsuda, S. Saito, and H. Sekihara. 1999. Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study. Jpn. J. Cancer Res. 90:367-371.
27. Teraguchi, S., H. Wakabayashi, H. Kuwata, K. Yamauchi, and Y. Tamura. 2004. Protection against infections by oral lactoferrin: evaluation in animal models. Biometals 17:231-234.
28. Togawa, J., H. Nagase, K. Tanaka, M. Inamori, A. Nakajima, N. Ueno, T. Saito, and H. Sekihara. 2002. Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. J. Gastroenterol. Hepatol. 17:1291-1298.
29. Togawa, J., H. Nagase, K. Tanaka, M. Inamori, T. Umezawa, A. Nakajima, M. Naito, S. Sato, T. Saito, and H. Sekihara. 2002. Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. Am. J. Physiol. Gastrointest. Liver Physiol. 283:G187-G195.
30. Tomita, M., H. Wakabayashi, K. Yamauchi, S. Teraguchi, and H. Hayasawa. 2002. Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochem. Cell Biol. 80:109-112.
31. Tsuda, H, K. Sekine, K. Fujita, and M. Iigo. 2002. Cancer prevention by bovine lactoferrin and underlying mechanisms-a review of experimental and clinical studies. Biochem. Cell Biol. 80:131-136.
32. Velliyagounder, K., J. B. Kaplan, D. Furgang, D. Legarda, G. Diamond, R. E. Parkin, and D. H. Fine. 2003. One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis. Infect. Immun. 71:6141-6147.
33. Wakabayashi, H., M. Kurokawa, K. Shin, S. Teraguchi, Y. Tamura, and K. Shiraki. 2004. Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice. Biosci. Biotechnol. Biochem. 68:537-544.
34. Wakabayashi, H., H. Kuwata, K. Yamauchi, S. Teraguchi, and Y. Tamura. 2004. No detectable transfer of dietary lactoferrin or its functional fragments to portal blood in healthy adult rats. Biosci. Biotechnol. Biochem. 68:853-860.
35. Wakabayashi, H., N. Takakura, S. Teraguchi, and Y. Tamura. 2003. Lactoferrin feeding augments peritoneal macrophage activities in mice intraperitoneally injected with inactivated Candida albicans. Microbiol. Immunol. 47:37-43.
36. Wakabayashi, H., K. Uchida, K. Yamauchi, S. Teraguchi, H. Hayasawa, and H. Yamaguchi. 2000. Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models. J. Antimicrob. Chemother. 46:595-601.
37. Wang, W. P., M. Iigo, J. Sato, K. Sekine, I. Adachi, and H. Tsuda. 2000. Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn. J. Cancer Res. 91:1022-1027.
38. Yamauchi, K., M. Hiruma, N. Yamazaki, H. Wakabayashi, H. Kuwata, S. Teraguchi, H. Hayasawa, N. Suegara, and H. Yamaguchi. 2000. Oral administration of bovine lactoferrin for treatment of tinea pedis. A placebo-controlled, double-blind study. Mycoses 43:197-202.