Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice

British Journal of Clinical Pharmacology

Volumn 49, Issue 2, 2000, Pages 139-144

  Tassaneeyakul, Wichittra ^a,b   Tassaneeyakul, Wongwiwat ^c   Vannaprasaht, Suda ^b   Yamazoe, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Faculty of Medicine   (Japan)

^c KHON KAEN UNIVERSITY   (Thailand)

Author keywords

CYP2C19; CYP3A4; Grapefruit juice; Interaction; Intestinal P450; Omeprazole; Proton pump inhibitor

Indexed keywords

OMEPRAZOLE; STOMACH SECRETION INHIBITOR;

AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; CITRUS; CROSS-OVER STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; MIXED FUNCTION OXYGENASES; OMEPRAZOLE; TIME FACTORS;

EID: 0033959307     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00122.x     Document Type: Article

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