Dictyostelium discoideum to human cells: Pharmacogenetic studies demonstrate a role for sphingolipids in chemoresistance

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 3, 2006, Pages 301-309

  Alexander, Stephen ^a   Min, Junxia ^a   Alexander, Hannah ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Cancer therapy; Ceramide; Cisplatin; Glutathione; MAP kinase; Signal transduction modulator; Sphingosine 1 phosphate

Indexed keywords

3 KETOSPHINGANINE REDUCTASE; ACYLSPHINGOSINE DEACYLASE; CAMPTOTHECIN; CARBOPLATIN; CERAMIDE GLUCOSYLTRANSFERASE; CISPLATIN; DACTINOMYCIN; DIHYDROCERAMIDE DESATURASE; DIHYDROCERAMIDE SYNTHASE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GLUCOSYLCERAMIDE SYNTHASE LIKE1; MICROBIAL ENZYME; S 1 P LYASE; S 1 P PHOSPHATASE; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN SYNTHASE; SPHINGOSINE KINASE; UNCLASSIFIED DRUG;

CANCER CHEMOTHERAPY; CELL DEATH; DICTYOSTELIUM DISCOIDEUM; DNA DAMAGE; DNA REPAIR; DRUG EFFICACY; DRUG SENSITIVITY; DRUG TARGETING; GENE IDENTIFICATION; HUMAN; LIFE CYCLE; LIPID DEGRADATION; LIPID METABOLISM; LIPOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW;

ALDEHYDE-LYASES; ANIMALS; CELL LINE; CELL LINE, TUMOR; CISPLATIN; DICTYOSTELIUM; DRUG RESISTANCE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHARMACOGENETICS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOLIPIDS;

ACRASIDA; DICTYOSTELIUM DISCOIDEUM; MAMMALIA;

EID: 33644905552     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2005.11.015     Document Type: Review

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