Mechanistic study of the cellular interplay of transport and metabolism using the synthetic modeling method

Pharmaceutical Research

Volumn 23, Issue 3, 2006, Pages 493-505

  Liu, Yu ^a   Hunt, C Anthony ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Agent based modeling; CYP3A4; Drug absorption; P glycoprotein; Simulation

Indexed keywords

CYTOCHROME P450 3A4; GLYCOPROTEIN P;

ARTICLE; CELL METABOLISM; CELL STRAIN CACO 2; CELL TRANSPORT; COMPETITIVE INHIBITION; COMPUTER PROGRAM; CONTROLLED STUDY; EXPERIMENTAL DESIGN; EXPERIMENTAL MODEL; EXPERIMENTATION; HUMAN; HUMAN CELL; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; METABOLITE; PRIORITY JOURNAL; SIMULATION;

CACO-2 CELLS; COMPUTER SIMULATION; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; TRANSFECTION;

EID: 33644904332     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9505-4     Document Type: Article

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