Mechanical strength of the titin Z1Z2-telethonin complex

Structure

Volumn 14, Issue 3, 2006, Pages 497-509

  Lee, Eric H ^a   Gao, Mu ^b   Pinotsis, Nikos ^c   Wilmanns, Matthias ^c   Schulten, Klaus ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b University of Illinois at Urbana Champaign   (United States)

^c DESY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; VELOCITY;

BINDING SITES; COMPUTER SIMULATION; DIMERIZATION; HYDROGEN BONDING; MODELS, MOLECULAR; MUSCLE PROTEINS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SARCOMERES; STRESS, MECHANICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644846751     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2005.12.005     Document Type: Article

References (58)

1. M.L. Bang, T. Centner, F. Fornoff, A.J. Geach, M. Gotthardt, M. McNabb, C.C. Witt, D. Labeit, C.C. Gregorio, and H. Granzier The complete gene sequence of titin, expression of an unusual approximate to 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system Circ. Res. 89 2001 1065 1072
2. C. Bonnemann, and N. Laing Myopathies resulting from mutations in sarcomeric proteins Curr. Opin. Neurol. 17 2004 529 537
3. D. Craig, M. Gao, K. Schulten, and V. Vogel Tuning the mechanical stability of fibronectin type III modules through sequence variation Structure 12 2004 21 30
4. H. Erickson Stretching single protein modules: titin is a weird spring Science 276 1997 1090 1093
5. G. Faulkner, G. Lanfranchi, and G. Valle Telethonin and other new proteins of the Z-disc of skeletal muscle Life 51 2001 275 282
6. D. Furst, M. Osborn, R. Nave, and K. Weber The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immuno-electron microscopy: a map of 10 non-repetitive epitopes starting at the Z-line extends to the M-line J. Cell Biol. 106 1988 1563 1572
7. T. Furukawa, Y. Ono, H. Tsuchiya, Y. Katayama, M. Bang, D. Labeit, S. Labeit, N. Inagaki, and C. Gregorio Specific interaction of potassium channel β-subunit mink with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system J. Mol. Biol. 313 2001 775 784
8. 10 by steered molecular dynamics J. Mol. Biol. 323 2002 939 950
9. M. Gao, H. Lu, and K. Schulten Unfolding of titin domains studied by molecular dynamics simulations J. Muscle Res. Cell Motil. 23 2002 513 521
10. M. Gao, M. Wilmanns, and K. Schulten Steered molecular dynamics studies of titin I1 domain unfolding Biophys. J. 83 2002 3435 3445
11. M. Gao, D. Craig, O. Lequin, I.D. Campbell, V. Vogel, and K. Schulten Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates Proc. Natl. Acad. Sci. USA 100 2003 14784 14789
12. M. Gautel, D. Goulding, B. Bullard, K. Weber, and D.O. Furst The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers J. Cell Sci. 109 1996 2747 2754
13. H.L. Granzier, and S. Labeit The giant protein titin a major player in myocardial mechanics, signaling and disease Circ. Res. 94 2004 284 295
14. F. Gräter, J. Shen, H. Jiang, M. Gautel, and H. Grubmüller Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations Biophys. J. 88 2005 790 804
15. 2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (Tcap) is required for sarcomeric integrity J. Cell Biol. 143 1998 1013 1027
16. H. Grubmüller, H. Heller, A. Windemuth, and K. Schulten Generalized Verlet algorithm for efficient molecular dynamics simulations with long-range interactions Mol. Sim. 6 1991 121 142
17. W. Humphrey, A. Dalke, and K. Schulten VMD: visual molecular dynamics J. Mol. Graph. 14 1996 33 38
18. B. Isralewitz, M. Gao, and K. Schulten Steered molecular dynamics and mechanical functions of proteins Curr. Opin. Struct. Biol. 11 2001 224 230
19. M. Itoh-Satoh, T. Hayashi, H. Nishi, Y. Koga, T. Arimura, T. Koyanagi, M. Takahashi, S. Hohda, K. Ueda, and T. Nouchi Titin mutations as the molecular basis for dilated cardiomyopathy Biochem. Biophys. Res. Commun. 291 2002 385 393
20. S. Izrailev, S. Stepaniants, M. Balsera, Y. Oono, and K. Schulten Molecular dynamics study of unbinding of the avidin-biotin complex Biophys. J. 72 1997 1568 1581
21. S. Izrailev, S. Stepaniants, B. Isralewitz, D. Kosztin, H. Lu, F. Molnar, W. Wriggers, and K. Schulten Steered molecular dynamics P. Deuflhard J. Hermans B. Leimkuhler A.E. Mark S. Reich R.D. Skeel Computational Molecular Dynamics: Challenges, Methods, Ideas, Volume 4 of Lecture Notes in Computational Science and Engineering 1998 Springer-Verlag Berlin 39 65
22. W.L. Jorgensen, J. Chandrasekhar, J.D. Madura, R.W. Impey, and M.L. Klein Comparison of simple potential functions for simulating liquid water J. Chem. Phys. 79 1983 926 935
23. J. Karanicolas, and C. Brooks The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design? Proc. Natl. Acad. Sci. USA 100 2003 3555 3556
24. R. Knöll, M. Hoshijima, H. Hoffman, V. Person, I. Lorenzen-Schmidt, M. Bang, T. Hayashi, N. Shiga, H. Yasukawa, and W. Schaper The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy Cell 111 2002 943 955
25. S. Kojic, E. Medeot, E. Guccione, H. Krmac, I. Zara, V. Martinelli, G. Valle, and G. Faulkner The Ankrd2 protein, a link between the sarcomere and the nuclear in skeletal muscle J. Mol. Biol. 339 2004 313 325
26. S. Lange, F. Xiang, A. Yakovenko, A. Vihola, P. Hackman, E. Rostkova, J. Kristensen, B. Brandmeier, G. Franzen, and B. Hedberg The kinase domain of titin controls muscle gene expression and protein turnover Science 308 2005 1599 1603
27. S. Laval, and K. Bushby Limb-girdle muscular dystrophies - from genetics to molecular pathology Neuropathol. Appl. Neurobiol. 30 2004 91 105
28. H. Li, C.V. Mariano, A.F. Oberhauser, P.E. Marszalek, and J.M. Fernandez Point mutations alter the mechanical stability of immunoglobulin modules Nat. Struct. Biol. 7 2001 1117 1120
29. W. Linke Stretching molecular springs: elasticity of titin filaments in vertebrate striated muscle Histol. Histolpathol. 15 2000 799 811
30. J. Louis, I. Byeon, U. Baxa, and A. Gronenborn The GB1 amyloid fibril: recruitment of the peripheral β-strands of the domain swapped dimer into the polymeric interface J. Mol. Biol. 348 2005 687 698
31. H. Lu, and K. Schulten Steered molecular dynamics simulations of force induced protein domain unfolding Proteins 35 1999 453 463
32. H. Lu, and K. Schulten The key event in force-induced unfolding of titin's immunoglobulin domains Biophys. J. 79 2000 51 65
33. H. Lu, B. Isralewitz, A. Krammer, V. Vogel, and K. Schulten Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation Biophys. J. 75 1998 662 671
34. A.D. MacKerell Jr., D. Bashford, M. Bellott, R.L. Dunbrack Jr., J. Evanseck, M.J. Field, S. Fischer, J. Gao, H. Guo, and S. Ha All-atom empirical potential for molecular modeling and dynamics studies of proteins J. Phys. Chem. B 102 1998 3586 3616
35. P.E. Marszalek, H. Lu, H. Li, M. Carrion-Vazquez, A.F. Oberhauser, K. Schulten, and J.M. Fernandez Mechanical unfolding intermediates in titin modules Nature 402 1999 100 103
36. K. Maruyama Connectin/titin, a giant elastic protein of muscle FASEB J. 11 1997 341 345
37. P. Mason, S. Bayol, and P. Loughna The novel sarcomeric protein telethonin exhibits developmental and functional regulation Biochem. Biophys. Res. Commun. 257 1999 699 703
38. M. Miller, H. Granzier, E. Ehler, and C. Gregorio The sensitive giant: the role of titin-based stretch sensing complexes Trends Cell Biol. 14 2004 119 126
39. A. Mues, P.F.M. van der Ven, P. Young, D.O. Furst, and M. Gautel Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin FEBS Lett. 428 1998 111 114
40. G. Nicholas, M. Thomas, B. Langley, W. Somers, K. Patel, C. Kemp, M. Sharma, and R. Kambadur Titin-cap associates with, and regulates secretion of, myostatin J. Cell. Physiol. 193 2002 120 131
41. A. Oberhauser, C. Badilla-Fernandez, M. Carrion-Vazquez, and J. Fernandez The mechanical hierarchies of fibronectin observed with single molecule AFM J. Mol. Biol. 319 2002 433 447
42. W. Obermann, M. Gautel, K. Weber, and D. Furst Molecular structure of the sarcomeric M-band: mapping of titin and myosin binding domains in myomesin and the identification of potential regulatory phosphorylation site in myomesin EMBO J. 16 1997 211 220
43. J.C. Phillips, R. Braun, W. Wang, J. Gumbart, E. Tajkhorshid, E. Villa, C. Chipot, R.D. Skeel, L. Kale, and K. Schulten Scalable molecular dynamics with NAMD J. Comput. Chem. 26 2005 1781 1802
44. J.W. Ponder, and D.A. Case Force fields for protein simulations V. Daggett Advances in Protein Chemistry Volume 66 2003 Academic Press San Diego 27 85
45. W.G. Pyle, and R.J. Solaro At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function Circ. Res. 94 2004 296 305
46. M. Rief, M. Gautel, F. Oesterhelt, J.M. Fernandez, and H.E. Gaub Reversible unfolding of individual titin immunoglobulin domains by AFM Science 276 1997 1109 1112
47. T. Schlick, R. Skeel, A. Brünger, L. Kalé, J.A. Board Jr., J. Hermans, and K. Schulten Algorithmic challenges in computational molecular biophysics J. Comput. Phys. 151 1999 9 48
48. R. Schröder, J. Reimann, A. Iakovenko, A. Mues, C. Bonnemann, J. Matten, and M. Gautel Early and selective disappearance of telethonin protein from the sarcomere in neurogenic atrophy J. Muscle Res. Cell Motil. 22 2001 259 264
49. L. Tjernberg, D. Callaway, A. Tjernberg, S. Hahne, C. Lilliehook, L. Terenius, J. Thyberg, and C. Nordstedt A molecular model of Alzheimer amyloid β-peptide fibril formation J. Biol. Chem. 274 1999 12619 12625
50. L. Tskhovrebova, and J. Trinick Titin: properties and family relationships Nat. Rev. Mol. Cell Biol. 4 2003 679 689
51. M. Vainzof, E. Moreira, O. Suzuki, G. Faulkner, G. Valle, A. Beggs, O. Carpen, A. Ribeiro, E. Zanoteli, and J. Gurgel-Gianneti Telethonin protein expression in neuromuscular disorders Biochim. Biophys. Acta 1588 2002 33 40
52. G. Valle, G. Faulkner, A. DeAntoni, P. Pacchioni, A. Pallavicini, D. Pandolfo, N. Tiso, S. Toppo, S. Trevisan, and G. Lanfranchi Telethonin, a novel sarcomeric protein of heart and skeletal muscle FEBS Lett. 415 1997 163 168
53. D. Walsh, D. Hartley, M. Condron, M. Selkoe, and D. Teplow In vitro studies of amyloid β-protein fibril assembly and toxicity provide clues to the aetiology of flemish variant (Ala692 → Gly) Alzheimer's disease Biochem. J. 355 2001 869 877
54. J. Wang, S. Gülich, C. Bradford, M. Ramirez-Avarado, and L. Regan A twisted four-sheeted model for an amyloid fibril Structure 13 2005 1279 1288
55. J. Wang, N. Shaner, B. Mittah, Q. Zhou, J. Chen, J. Sanger, and J. Sanger Dynamics of Z-band based proteins in developing skeletal muscle cells Cell Motil. Cytoskeleton 61 2005 34 48
56. K. Wang Titin/connectin and nebulin: giant protein ruler of muscle structure and function Adv. Biophys. 33 1996 123 134
57. P. Zou, M. Gautel, A. Geerlof, M. Wilmanns, M.H. Koch, and D.H. Svergun Solution scattering suggests cross-linking function of telethonin in complex with titin J. Biol. Chem. 278 2003 2636 2644
58. P. Zou, N. Pinotsis, S. Lange, Y.H. Song, A. Popov, I. Mavridis, O.M. Mayans, M. Gautel, and M. Wilmanns Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk Nature 439 2006 229 233