Stretching molecular springs: Elasticity of titin filaments in vertebrate striated muscle

Histology and Histopathology

Volumn 15, Issue 3, 2000, Pages 799-811

  Linke, W A ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cardiac muscle; Connectin; Passive tension; Skeletal muscle; Wormlike chain

Indexed keywords

CONNECTIN; IMMUNOGLOBULIN G; MUSCLE PROTEIN;

ELASTICITY; HEART MUSCLE; HUMAN; MEMBRANE STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR STABILITY; MYOFILAMENT; REVIEW; SARCOMERE LENGTH; SKELETAL MUSCLE; TENSION;

ANIMALS; ELASTICITY; HUMANS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN KINASES; VERTEBRATES;

VERTEBRATA;

EID: 0033928461     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (98)

1. The cellular basis of the length-tension relation in cardiac muscle
2. Active tension generation in isolated skeletal myofibrils
3. Entropic elasticity of λ-phage DNA
4. Ultrastructure of the resting and contracted striated muscle fiber at different degrees of stretch
5. Mechanical and chemical unfolding of a single protein: A comparison
6. Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin
7. Stretching single protein molecules: Titin is a weird spring
8. Elastic filaments in skeletal muscle revealed by selective removal of thin filaments with plasma gelsolin
9. Elastic filaments in situ in cardiac muscle: Deep-etch replica analysis in combination with selective removal of actin and myosin filaments
10. The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: A map of ten nonrepetitive epitopes starting at the Z-line extends close to the M-line
11. Repetitive titin epitopes with a 42 nm spacing coincide in relative position with known A band striations also identified by major myosin-associated proteins; an immunoelectron microscopical study on myofibrils
12. Elongation of the primary myofilaments in highly stretched insect flight muscle fibrils
13. A molecular map of titin/connectin elasticity reveals two different mechanisms acting in series
14. Assembly of the cardiac I-band region of titin/connectin: Expression of the cardiac-specific regions and their relation to the elastic segments
15. Passive tension in cardiac muscle: Contribution of collagen, titin, microtubules, and intermediate filaments
16. Passive tension and stiffness of vertebrate skeletal and insect flight muscles: The contribution of weak cross-bridges and elastic filaments
17. Nonuniform elasticity of titin in cardiac myocytes: A study using immunoelectron microscopy and cellular mechanics
18. Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction
19. Muscle assembly: A titanic achievement?
20. The NH2 terminus of titin spans the Z disc; its interaction with a novel 19 kD ligand (T-cap) is required for sarcomeric integrity
21. Ultrastructure of myofibrils after selective protein extraction
22. Interactions and conformational studies of PEVK segment of human fetal skeletal muscle titin
23. The structural basis of contraction in striated muscle
24. Titin develops restoring force in rat cardiac myocytes
25. Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: Titin is an adjustable spring
26. Characterization of β-connectin (titin 2) from striated muscle by dynamic light scattering
27. Localization and elasticity of connectin (titin) filaments in skinned frog muscle fibres subjected to partial depolymerization of thick filaments
28. Thick filament movement and isometric tension in activated skeletal muscle
29. A physiological role for titin and nebulin in skeletal muscle
30. Elastic behavior of connectin filaments during thick filament movement in activated skeletal muscle
31. Studies of the interaction between titin and myosin
32. Structural changes in muscle during contraction
33. The maximum length for contraction in vertebrate striated muscle
34. Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation
35. Immunoglobulin-like modules from I-band titin: Extensible components of muscle elasticity
36. Extensible and less-extensible domains of connectin filaments in stretched vertebrate skeletal muscle as detected by immunofluorescence and immunoelectron microscopy using monoclonal antibodies
37. Cloned rat cardiac titin class I and class II motifs
38. Calcium-dependent inhibition of thin-filament motility by native titin
39. Folding-unfolding transitions in single titin molecules characterized with laser tweezers
40. Giant polypeptides of skeletal muscle titin: Sedimentation equilibrium in guanidine hydrochloride
41. Titins, giant proteins in charge of muscle ultrastructure and elasticity
42. A regular pattern of two types of 100-residue motif in the sequence of titin
43. Towards a molecular understanding of titin
44. The giant protein titin. Emerging roles in physiology and pathophysiology
45. A spring tale: New facts on titin elasticity
46. Passive and active tension in single cardiac myofibrils
47. Towards a molecular understanding of the elasticity of titin
48. Actin-titin interaction in cardiac myofibrils: Probing a physiological role
49. Nature of PEVK-titin elasticity in skeletal muscle
50. Characterizing titin's I-band Ig domain region as an entropic spring
51. I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure
52. Gap filaments-the third set in the myofibril
53. Myofibrils bear most of the resting tension in frog skeletal muscle
54. Stretching DNA
55. Connectin, an elastic protein of striated muscle
56. Connectin, an elastic protein of muscle: Characterization and function
57. Molecular size and shape of β-connectin, an elastic protein of striated muscle
58. Connectin filaments link thick filaments and Z lines in frog skeletal muscle as revealed by immunoelectron microscopy
59. Binding of actin filaments to connectin
60. Structural basis for activation of the titin kinase domain during myofibrillogenesis
61. Evidence for superthin filaments
62. Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin
63. The 3D structure of a type I module from titin: A prototype of intracellular fibronectin type III domains
64. Visualization of the polarity of isolated titin molecules: A single globular head on a long thin rod as the M Band anchoring domain?
65. The structure of the sarcomeric M band: Localization of defined domains of myomesin, M protein, and the 250 kD carboxy terminal region of titin by immunoelectron microscopy
66. Molecular structure of the sarcomeric M band: Mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin
67. Binding of the N-terminal 63 kDa portion of connectin/titin to α-actinin as revealed by the yeast two-hybrid system
68. Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: A new member of the I set
69. Immunoglobulin-type domains of titin: Same fold, different stability?
70. The folding and stability of titin immunoglobulin-like modules, with implications for the mechanism of elasticity
71. The elastic I-band region of titin is assembled in a 'modular' fashion by weakly interacting Ig-like domains
72. Reversible unfolding of individual titin immunoglobulin domains by AFM
73. The mechanical stability of immunoglobulin and fibronectin III domains in the muscle protein titin measured by atomic force microscopy
74. A method to reconstruct myocardial sarcomere lengths and orientations at transmural sites in beating canine hearts
75. The connections between A- and I-band filaments in striated frog muscle
76. Tissue-specific expression and alpha-actinin binding properties of the Z disc titin. Implications for the nature of vertebrate Z discs
77. A survey of the interactions made by titin
78. The cytoskeleton in skeletal, cardiac and smooth muscle cells
79. Cytoskeleton: Titin as a scaffold and spring
80. Purification and properties of native titin
81. Actin removal from cardiac myocytes shows that near the Z-line titin attaches to actin while under tension
82. Elastic properties of connecting filaments along the sarcomere
83. Direct evidence for connecting C filaments in flight muscle of honey bee
84. Nature and origin of gap filaments in striated muscle
85. Elastic properties of titin filaments demonstrated using a 'freeze-break' technique
86. The mechanically active domain of titin in cardiac muscle
87. Titin extensibility in situ: Entropic elasticity of permanently folded and permanently unfolded molecular segments
88. Direct visualization of extensibility in isolated titin molecules
89. Elasticity and unfolding of single molecules of the giant muscle protein titin
90. Regulation of skeletal muscle stiffness and elasticity by titin isoforms: A test of the segmental extension model of resting tension
91. Viscoelasticity of the sarcomere matrix of skeletal muscles. The titin-myosin composite filament is a dual-stage molecular spring
92. Titin: Major myofibrillar component of striated muscle
93. Titin is an extraordinary long, flexible, and slender myofibrillar protein
94. Stretching DNA with optical tweezers
95. The kinetics of muscle contraction
96. Does titin regulate the length of muscle thick filaments?
97. Molecular structure of the sarcomeric Z-disk: Two types of interaction lead to an asymmetrical sorting of α-actinin
98. A kinetic molecular model of the reversible unfolding and refolding of titin under force extension