Ghrelin and cardiovascular health

Current Opinion in Pharmacology

Volumn 6, Issue 2, 2006, Pages 142-147

  García, Edwin A ^a   Korbonits, Márta ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE; DOXORUBICIN; GHRELIN; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HEXARELIN; ISOPRENALINE; LACTATE DEHYDROGENASE; MALONALDEHYDE;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CELL CULTURE; CELL ENERGY; CYTOTOXICITY; EXPERIMENTAL MODEL; GROWTH HORMONE RELEASE; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; HYPERTENSION; INCREASED APPETITE; INHIBITION KINETICS; ISCHEMIC HEART DISEASE; MEAN ARTERIAL PRESSURE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RABBIT; RAT; REPERFUSION INJURY; REVIEW; SYMPATHETIC NERVE; TISSUE DISTRIBUTION;

ANIMALS; CARDIAC OUTPUT, LOW; HUMANS; HYPERTENSION; MYOCARDIAL ISCHEMIA; PEPTIDE HORMONES;

EID: 33644835427     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2005.10.006     Document Type: Review

References (34)

1. M. Kojima H. Hosoda Y. Date M. Nakazato H. Matsuo K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656-660
2. M. Korbonits A.P. Goldstone M. Gueorguiev A.B. Grossman Ghrelin - a hormone with multiple functions Front Neuroendocrinol 25 2004 27-68
3. A.D. Howard S.D. Feighner D.F. Cully J.P. Arena P.A. Liberator C.I. Rosenblum M. Hamelin D.L. Hreniuk O.C. Palyha J. Anderson et. al. A receptor in pituitary and hypothalamus that functions in growth hormone release Science 273 1996 974-977
4. N. Nagaya J. Moriya Y. Yasumura M. Uematsu F. Ono W. Shimizu K. Ueno M. Kitakaze K. Miyatake K. Kangawa Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 110 2004 3674-3679
5. N. Nagaya M. Uematsu M. Kojima Y. Ikeda F. Yoshihara W. Shimizu H. Hosoda Y. Hirota H. Ishida H. Mori et. al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430-1435
6. N. Nagaya M. Kojima M. Uematsu M. Yamagishi H. Hosoda H. Oya Y. Hayashi K. Kangawa Hemodynamic and hormonal effects of human ghrelin in healthy volunteers Am J Physiol Regul Integr Comp Physiol 280 2001 R1483-R1487
7. N. Nagaya K. Miyatake M. Uematsu H. Oya W. Shimizu H. Hosoda M. Kojima N. Nakanishi H. Mori K. Kangawa Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure J Clin Endocrinol Metab 86 2001 5854-5859
8. J.J. McMurray M.A. Pfeffer Heart failure Lancet 365 2005 1877-1889
9. G. Baldanzi N. Filigheddu S. Cutrupi F. Catapano S. Bonissoni A. Fubini D. Malan G. Baj R. Granata F. Broglio et. al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT J Cell Biol 159 2002 1029-1037
10. M.J. Iglesias R. Pineiro M. Blanco R. Gallego C. Dieguez O. Gualillo J.R. Gonzalez-Juanatey F. Lago Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes Cardiovasc Res 62 2004 481-488
11. D.E. Cummings J.Q. Purnell R.S. Frayo K. Schmidova B.E. Wisse D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714-1719
12. H. Okumura N. Nagaya M. Enomoto E. Nakagawa H. Oya K. Kangawa Vasodilatory effect of ghrelin, an endogenous peptide from the stomach J Cardiovasc Pharmacol 39 2002 779-783
13. K.E. Wiley A.P. Davenport Comparison of vasodilators in human internal mammary artery: Ghrelin is a potent physiological antagonist of endothelin-1 Br J Pharmacol 136 2002 1146-1152
14. Y. Lin K. Matsumura M. Fukuhara S. Kagiyama K. Fujii M. Iida Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats Hypertension 43 2004 977-982
15. K. Matsumura T. Tsuchihashi K. Fujii I. Abe M. Iida Central ghrelin modulates sympathetic activity in conscious rabbits Hypertension 40 2002 694-699
16. Y. Shimizu N. Nagaya Y. Teranishi M. Imazu H. Yamamoto T. Shokawa K. Kangawa N. Kohno M. Yoshizumi Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats Biochem Biophys Res Commun 310 2003 830-835
17. M. Tschop C. Weyer P.A. Tataranni V. Devanarayan E. Ravussin M.L. Heiman Circulating ghrelin levels are decreased in human obesity Diabetes 50 2001 707-709
18. M. Suematsu A. Katsuki Y. Sumida E.C. Gabazza S. Murashima K. Matsumoto N. Kitagawa H. Akatsuka Y. Hori K. Nakatani et. al. Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects Eur J Endocrinol 153 2005 403-407
19. J.Y. Altarejos M. Taniguchi A.S. Clanachan G.D. Lopaschuk Myocardial ischemia differentially regulates LKB1 and an alternate 5′-AMP-activated protein kinase kinase J Biol Chem 280 2005 183-190
20. S.J. Baron J. Li R.R. Russell III D. Neumann E.J. Miller R. Tuerk T. Wallimann R.L. Hurley L.A. Witters L.H. Young Dual mechanisms regulating AMPK kinase action in the ischemic heart Circ Res 96 2005 337-345
21. R.R. Russell III R. Bergeron G.I. Shulman L.H. Young Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR Am J Physiol 277 1999 H643-H649
22. A.S. Marsin L. Bertrand M.H. Rider J. Deprez C. Beauloye M.F. Vincent G. Van den Berghe D. Carling L. Hue Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia Curr Biol 10 2000 1247-1255
23. R.R. Russell III J. Li D.L. Coven M. Pypaert C. Zechner M. Palmeri F.J. Giordano J. Mu M.J. Birnbaum L.H. Young AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury J Clin Invest 114 2004 495-503
24. D.G. Hardie New roles for the LKB1→AMPK pathway Curr Opin Cell Biol 17 2005 167-173
25. B. Kola E. Hubina S.A. Tucci T.C. Kirkham E.A. Garcia S.E. Mitchell L.M. Williams S.A. Hawley D.G. Hardie A.B. Grossman et. al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase J Biol Chem 280 2005 25196-25201
26. L. Chang J. Zhao G.Z. Li B. Geng C.S. Pan Y.F. Qi C.S. Tang Ghrelin protects myocardium from isoproterenol-induced injury in rats Acta Pharmacol Sin 25 2004 1131-1137
27. L. Chang Y. Ren X. Liu W.G. Li J. Yang B. Geng N.L. Weintraub C. Tang Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart J Cardiovasc Pharmacol 43 2004 165-170
28. J.J. Pang R.K. Xu X.B. Xu J.M. Cao C. Ni W.L. Zhu K. Asotra M.C. Chen C. Chen Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro Am J Physiol Heart Circ Physiol 286 2004 H1063-H1069
29. S. Frascarelli S. Ghelardoni S. Ronca-Testoni R. Zucchi Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart Basic Res Cardiol 98 2003 401-405
30. A. Demers N. McNicoll M. Febbraio M. Servant S. Marleau R. Silverstein H. Ong Identification of the growth hormone-releasing peptide binding site in CD36: A photoaffinity cross-linking study Biochem J 382 2004 417-424
31. G. Taubes Cardiovascular disease. Does inflammation cut to the heart of the matter? Science 296 2002 242-245
32. V.D. Dixit E.M. Schaffer R.S. Pyle G.D. Collins S.K. Sakthivel R. Palaniappan J.W. Lillard Jr. D.D. Taub Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells J Clin Invest 114 2004 57-66
33. J.V. Zhang P.G. Ren O. Avsian-Kretchmer C.W. Luo R. Rauch C. Klein A.J. Hsueh Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake Science 310 2005 996-999
34. K.K. McKee C.P. Tan O.C. Palyha J. Liu S.D. Feighner D.L. Hreniuk R.G. Smith A.D. Howard L.H. Van der Ploeg Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors Genomics 46 1997 426-434