Elevated levels of ornithine decarboxylase cooperate with Raf/ERK activation to convert normal keratinocytes into invasive malignant cells

Oncogene

Volumn 25, Issue 10, 2006, Pages 1543-1553

  Hayes, C S ^a   DeFeo, K ^a   Lan, L ^a   Paul, B ^a   Sell, C ^a   Gilmour, S K ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Akt; Invasion; Ornithine decarboxylase; Polyamines; Raf ERK

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; ORNITHINE DECARBOXYLASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAC PROTEIN; RAF PROTEIN; RAL PROTEIN; RALGDS PROTEIN; RAS PROTEIN; RASV12 PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL INVASION; CELL LEVEL; CELL TRANSFORMATION; ENZYME ACTIVATION; ENZYME INDUCTION; GENE OVEREXPRESSION; KERATINOCYTE; MALIGNANT TRANSFORMATION; MOUSE; NEWBORN; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETROVIRUS VECTOR; SIGNAL TRANSDUCTION; TRACHEA; TRANSGENIC MOUSE; XENOTRANSPLANTATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; NIH 3T3 CELLS; ORNITHINE DECARBOXYLASE; POLYAMINES; PROTO-ONCOGENE PROTEINS C-AKT; RAC GTP-BINDING PROTEINS; RAF KINASES; RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA; MUS MUSCULUS; RETROVIRIDAE;

EID: 33644833717     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209198     Document Type: Article

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