메뉴 건너뛰기




Volumn 125, Issue 6, 2005, Pages 1242-1251

Recurrent patterns of dual RB and p53 pathway inactivation in melanoma

Author keywords

CDK4; CDKN2A; Genetics; Melanoma p53

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; DNA; PROTEIN P53; RETINOBLASTOMA PROTEIN; PROTEIN P16INK4A;

EID: 33644825279     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23931.x     Document Type: Article
Times cited : (54)

References (30)
  • 1
    • 0034997650 scopus 로고    scopus 로고
    • Dual inactivation of RB and p53 pathways in RAS-induced melanomas
    • Bardeesy N, Bastian BC, Hezel A, et al: Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol 21:2144-2153, 2001
    • (2001) Mol Cell Biol , vol.21 , pp. 2144-2153
    • Bardeesy, N.1    Bastian, B.C.2    Hezel, A.3
  • 2
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova J, Lukas J, Guldberg R et al: The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 56:5475-5483, 1996
    • (1996) Cancer Res , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, R.3
  • 3
    • 0030728259 scopus 로고    scopus 로고
    • CDKN2A/p16 is inactivated in most melanoma cell lines
    • Castellano M, Pollock PM, Walters MK, et al: CDKN2A/p16 is inactivated in most melanoma cell lines. Cancer Res 57:4868-4875, 1997
    • (1997) Cancer Res , vol.57 , pp. 4868-4875
    • Castellano, M.1    Pollock, P.M.2    Walters, M.K.3
  • 4
    • 0030729474 scopus 로고    scopus 로고
    • Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
    • Chin L, Pomerantz J, Polsky D, et al: Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev 11:2822-2834, 1997
    • (1997) Genes Dev , vol.11 , pp. 2822-2834
    • Chin, L.1    Pomerantz, J.2    Polsky, D.3
  • 5
    • 4043055279 scopus 로고    scopus 로고
    • BRAF alterations are associated with complex mutational profiles in malignant melanoma
    • Daniotti M, Oggionni M, Ranzani T, et al: BRAF alterations are associated with complex mutational profiles in malignant melanoma. Oncogene 23:5968-5977, 2004
    • (2004) Oncogene , vol.23 , pp. 5968-5977
    • Daniotti, M.1    Oggionni, M.2    Ranzani, T.3
  • 6
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al: Mutations of the BRAF gene in human cancer. Nature 417:949-954, 2002
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 7
    • 0038128356 scopus 로고    scopus 로고
    • Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations
    • Eskandarpour M, Hashemi J, Kanter L, et al: Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations. J Natl Cancer Inst 95:790-798, 2003
    • (2003) J Natl Cancer Inst , vol.95 , pp. 790-798
    • Eskandarpour, M.1    Hashemi, J.2    Kanter, L.3
  • 8
    • 0029658666 scopus 로고    scopus 로고
    • INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma
    • INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. Cancer Res 56:5023-5032, 1996
    • (1996) Cancer Res , vol.56 , pp. 5023-5032
    • Flores, J.R.1    Walker, G.J.2    Glendening, J.M.3
  • 9
    • 4143149771 scopus 로고    scopus 로고
    • Genetic testing in familial melanoma
    • Nickoloff BJ (ed). Totowa, NJ: Humana Press Inc.
    • Hogg D, Liu L, Lassam N: Genetic testing in familial melanoma. In: Nickoloff BJ (ed). Melanoma: Methods and Protocols, Vol. 61: Methods in Molecular Medicine. Totowa, NJ: Humana Press Inc., 2001
    • (2001) Melanoma: Methods and Protocols , vol.61
    • Hogg, D.1    Liu, L.2    Lassam, N.3
  • 11
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • Kamb A, Gruis N, Weaver-Feldhaus J, et al: A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440, 1994
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1    Gruis, N.2    Weaver-Feldhaus, J.3
  • 12
    • 0032545582 scopus 로고    scopus 로고
    • Mutations in the CDKN2A (p16ink4a) gene in microdissected sporadic primary melanomas
    • Kumar R, Rozell BL, Louhelainen J, et al: Mutations in the CDKN2A (p16ink4a) gene in microdissected sporadic primary melanomas. Int J Cancer 75:193-198, 1998a
    • (1998) Int J Cancer , vol.75 , pp. 193-198
    • Kumar, R.1    Rozell, B.L.2    Louhelainen, J.3
  • 13
    • 0031695202 scopus 로고    scopus 로고
    • Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines
    • Kumar R, Sauroja I, Punnonen K, et al: Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines. Genes Chromosomes Cancer 23:273-277, 1998b
    • (1998) Genes Chromosomes Cancer , vol.23 , pp. 273-277
    • Kumar, R.1    Sauroja, I.2    Punnonen, K.3
  • 14
    • 0035923248 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the 3′ untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare
    • Kumar R, Smeds J, Berggren P, et al: A single nucleotide polymorphism in the 3′ untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. Int J Cancer 95:388-393, 2001
    • (2001) Int J Cancer , vol.95 , pp. 388-393
    • Kumar, R.1    Smeds, J.2    Berggren, P.3
  • 15
    • 0032794625 scopus 로고    scopus 로고
    • Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): Homozygous deletions and mutations in the p16 and p14ARF genes in sporadic primary melanomas
    • Kumar R, Smeds J, Lundh Rozell B, et al: Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): Homozygous deletions and mutations in the p16 and p14ARF genes in sporadic primary melanomas. Melanoma Res 9:138-147, 1999
    • (1999) Melanoma Res , vol.9 , pp. 138-147
    • Kumar, R.1    Smeds, J.2    Lundh Rozell, B.3
  • 16
    • 0029963811 scopus 로고    scopus 로고
    • Involvement of the pRb/p16/cdk4/cyclinD1 pathway in the tumorigenesis of spordic malignant melanomas
    • Maelandsmo GM, Florenes VA, Hovig E, et al: Involvement of the pRb/p16/cdk4/cyclinD1 pathway in the tumorigenesis of spordic malignant melanomas. Br J Cancer 73:909-916, 1996
    • (1996) Br J Cancer , vol.73 , pp. 909-916
    • Maelandsmo, G.M.1    Florenes, V.A.2    Hovig, E.3
  • 17
    • 0027946010 scopus 로고
    • Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma
    • Ohta M, Nagai H, Shimizu M, et al: Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma. Cancer Res 54:5269-5272, 1994
    • (1994) Cancer Res , vol.54 , pp. 5269-5272
    • Ohta, M.1    Nagai, H.2    Shimizu, M.3
  • 18
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J, Schreiber-Agus N, Liegeois NJ, et al: The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92:713-723, 1998
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liegeois, N.J.3
  • 19
    • 0036713510 scopus 로고    scopus 로고
    • Human non-synonymous SNPs: Server and survey
    • Ramensky V, Bork R Sunyaev S: Human non-synonymous SNPs: Server and survey. Nucleic Acids Res 30:3894-3900, 2002
    • (2002) Nucleic Acids Res , vol.30 , pp. 3894-3900
    • Ramensky, V.1    Bork, R.2    Sunyaev, S.3
  • 20
    • 0035798659 scopus 로고    scopus 로고
    • Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF
    • Rizos H, Darmanian AP, Holland EA, et al: Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF. J Biol Chem 276:41424-41434, 2001
    • (2001) J Biol Chem , vol.276 , pp. 41424-41434
    • Rizos, H.1    Darmanian, A.P.2    Holland, E.A.3
  • 21
    • 0032517341 scopus 로고    scopus 로고
    • The p16INK4a/CDKN2A tumor suppressor and its relatives
    • Ruas M, Peters G: The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1378:115-177, 1998
    • (1998) Biochim Biophys Acta , vol.1378 , pp. 115-177
    • Ruas, M.1    Peters, G.2
  • 22
    • 0042785967 scopus 로고    scopus 로고
    • Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo
    • Sharpless NE, Kannan K, Xu J, et al: Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene 22:5055-5059, 2003
    • (2003) Oncogene , vol.22 , pp. 5055-5059
    • Sharpless, N.E.1    Kannan, K.2    Xu, J.3
  • 23
    • 0034191958 scopus 로고    scopus 로고
    • Towards a structural basis of human non-synonymous single nucleotide polymorphisms
    • Sunyaev S, Ramensky V, Bork P: Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Trends Genet 16:198-200, 2000
    • (2000) Trends Genet , vol.16 , pp. 198-200
    • Sunyaev, S.1    Ramensky, V.2    Bork, P.3
  • 24
    • 0035869223 scopus 로고    scopus 로고
    • Prediction of deleterious human alleles
    • Sunyaev S, Ramensky V, Koch I, et al: Prediction of deleterious human alleles. Hum Mol Genet 10:591-597, 2001
    • (2001) Hum Mol Genet , vol.10 , pp. 591-597
    • Sunyaev, S.1    Ramensky, V.2    Koch, I.3
  • 25
    • 0034090124 scopus 로고    scopus 로고
    • Update on familial cancer syndromes and the skin
    • quiz 970-972
    • Tsao H: Update on familial cancer syndromes and the skin. J Am Acad Dermatol 42:939-969, 2000; quiz 970-972
    • (2000) J Am Acad Dermatol , vol.42 , pp. 939-969
    • Tsao, H.1
  • 26
    • 0031963952 scopus 로고    scopus 로고
    • Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene
    • Tsao H, Benoit E, Sober AJ, et al: Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene. Cancer Res 58:109-113, 1998a
    • (1998) Cancer Res , vol.58 , pp. 109-113
    • Tsao, H.1    Benoit, E.2    Sober, A.J.3
  • 27
    • 1442274619 scopus 로고    scopus 로고
    • Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
    • Tsao H, Goel V, Wu H, et al: Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol 122:337-341, 2004
    • (2004) J Invest Dermatol , vol.122 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3
  • 28
    • 0032474749 scopus 로고    scopus 로고
    • Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
    • Tsao H, Zhang X, Benoit E, et al: Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene 16:3397-3402, 1998b
    • (1998) Oncogene , vol.16 , pp. 3397-3402
    • Tsao, H.1    Zhang, X.2    Benoit, E.3
  • 29
    • 0031980540 scopus 로고    scopus 로고
    • Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets
    • Walker GJ, Flores JF, Glendening JM, et al: Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosomes Cancer 22:157-163, 1998
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 157-163
    • Walker, G.J.1    Flores, J.F.2    Glendening, J.M.3
  • 30
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG: ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-734, 1998
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.