메뉴 건너뛰기




Volumn 57, Issue 21, 1997, Pages 4868-4875

CDKN2A/p16 is inactivated in most melanoma cell lines

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; PROTEIN P16;

EID: 0030728259     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (133)

References (57)
  • 3
    • 0028013327 scopus 로고
    • Linkage of cutaneous melanoma/dysplastic nevi to chromosome 9p, and evidence for genetic heterogeneity
    • Goldstein, A., Dracopoli, N., Engelstein, M., Fraser, M., Clark, W. H., Jr., and Tucker, M. Linkage of cutaneous melanoma/dysplastic nevi to chromosome 9p, and evidence for genetic heterogeneity. Am. J. Hum. Genet., 54: 489-496, 1994.
    • (1994) Am. J. Hum. Genet. , vol.54 , pp. 489-496
    • Goldstein, A.1    Dracopoli, N.2    Engelstein, M.3    Fraser, M.4    Clark Jr., W.H.5    Tucker, M.6
  • 4
    • 0029038538 scopus 로고
    • CDKN2A explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families
    • Gruis, N., Sandkuijl, L. A., van der Velden, P. A., Bergman, W. and Frants, R. R. CDKN2A explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families. Melanoma Res., 5: 169-177, 1995.
    • (1995) Melanoma Res. , vol.5 , pp. 169-177
    • Gruis, N.1    Sandkuijl, L.A.2    Van Der Velden, P.A.3    Bergman, W.4    Frants, R.R.5
  • 6
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., and Carson, D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368: 753-756, 1994.
    • (1994) Nature (Lond.) , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 7
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366: 704-707, 1993.
    • (1993) Nature (Lond.) , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 9
    • 0030025518 scopus 로고    scopus 로고
    • Compilation of somatic mutations of the CDKN2 gene in human cancers: Non-random distribution of base substitutions
    • Pollock, P. M., Pearson, J. V., and Hayward, N. K. Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions. Genes Chromosomes Cancer, 15: 77-88, 1996.
    • (1996) Genes Chromosomes Cancer , vol.15 , pp. 77-88
    • Pollock, P.M.1    Pearson, J.V.2    Hayward, N.K.3
  • 12
    • 0028972730 scopus 로고
    • Abnormalities in the CDKN2A (p16INK4/MTS-1) gene in human melanoma cells: Relevance to tumor growth and metastasis
    • Luca, M., Xie, S., Gutman, M., Huang, S., and Bar-Eli, M. Abnormalities in the CDKN2A (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis. Oncogene, 11: 1399-1402, 1995.
    • (1995) Oncogene , vol.11 , pp. 1399-1402
    • Luca, M.1    Xie, S.2    Gutman, M.3    Huang, S.4    Bar-Eli, M.5
  • 13
    • 0029147195 scopus 로고
    • Evidence of UV induction of CDKN2 mutations in melanoma cell lines
    • Pollock, P. M., Yu, F., Qiu, L., Parsons, P. G., and Hayward, N. K. Evidence of UV induction of CDKN2 mutations in melanoma cell lines. Oncogene, 11: 663-668, 1995.
    • (1995) Oncogene , vol.11 , pp. 663-668
    • Pollock, P.M.1    Yu, F.2    Qiu, L.3    Parsons, P.G.4    Hayward, N.K.5
  • 16
    • 0029664945 scopus 로고    scopus 로고
    • Infrequent mutation of p16INK4 in sporadic melanoma
    • Healy, E., Sikkink, S., and Rees, J. L. Infrequent mutation of p16INK4 in sporadic melanoma. J. Invest. Dermatol., 107: 318-321, 1996.
    • (1996) J. Invest. Dermatol. , vol.107 , pp. 318-321
    • Healy, E.1    Sikkink, S.2    Rees, J.L.3
  • 19
    • 0030067374 scopus 로고    scopus 로고
    • Mutational analysis of the CDKN2 gene in metastases from patients with cutaneous malignant melanoma
    • Platz, A., Ringborg, U., Lagerlof, B., Lundqvist, E., Sevigny, P., and Inganas, M. Mutational analysis of the CDKN2 gene in metastases from patients with cutaneous malignant melanoma. Br. J. Cancer, 73: 344-348, 1996.
    • (1996) Br. J. Cancer , vol.73 , pp. 344-348
    • Platz, A.1    Ringborg, U.2    Lagerlof, B.3    Lundqvist, E.4    Sevigny, P.5    Inganas, M.6
  • 20
    • 0029947139 scopus 로고    scopus 로고
    • The current situation with regard to human melanoma and genetic inferences
    • Hayward, N. K. The current situation with regard to human melanoma and genetic inferences. Curr. Opin. Oncol., 8: 136-142, 1996.
    • (1996) Curr. Opin. Oncol. , vol.8 , pp. 136-142
    • Hayward, N.K.1
  • 21
    • 0028075611 scopus 로고
    • Cdk inhibitors: On the threshold of checkpoints and development
    • Elledge, S., and Harper, J. W. Cdk inhibitors: on the threshold of checkpoints and development. Curr. Opin. Cell Biol., 6: 847-852, 1994.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 847-852
    • Elledge, S.1    Harper, J.W.2
  • 22
    • 0029119740 scopus 로고
    • Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
    • Grana, X., and Reddy, E. P. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene, 11: 211-219, 1995.
    • (1995) Oncogene , vol.11 , pp. 211-219
    • Grana, X.1    Reddy, E.P.2
  • 23
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr, C. J., and Roberts, J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev., 9: 1149-1163, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 25
    • 0029052951 scopus 로고
    • Tumor-derived p16 alleles encoding proteins defective in cell-cycle inhibition
    • Koh, J., Enders, G. H., Dynlacht, B. D., and Harlow, E. Tumor-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature (Lond.), 375: 506-510, 1995.
    • (1995) Nature (Lond.) , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.H.2    Dynlacht, B.D.3    Harlow, E.4
  • 26
    • 0028979432 scopus 로고
    • Mutational effects on the p16Ink4a tumor suppressor protein
    • Yang, R., Gombart, A. F., Serrano, M., and Koeffler, H. P. Mutational effects on the p16Ink4a tumor suppressor protein. Cancer Res., 55: 2503-2506, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 2503-2506
    • Yang, R.1    Gombart, A.F.2    Serrano, M.3    Koeffler, H.P.4
  • 30
    • 0028066664 scopus 로고
    • Localization of the human Mxi1 transcription factor gene (MX11) to chromosome 10q24-q25
    • Wechsler, D. S., Hawkins, A. L., Li, X., Wang Jabs, E., Griffin, C. A., and Dang, C. V. Localization of the human Mxi1 transcription factor gene (MX11) to chromosome 10q24-q25. Genomics, 21: 669-672, 1994.
    • (1994) Genomics , vol.21 , pp. 669-672
    • Wechsler, D.S.1    Hawkins, A.L.2    Li, X.3    Wang Jabs, E.4    Griffin, C.A.5    Dang, C.V.6
  • 33
    • 0029915596 scopus 로고    scopus 로고
    • Differential expression of the cyclin-dependent kinase inhibitors p16 and p21 in the human melanocytic system
    • Wang, Y., and Becker, D. Differential expression of the cyclin-dependent kinase inhibitors p16 and p21 in the human melanocytic system. Oncogene, 12: 1069-1075, 1996.
    • (1996) Oncogene , vol.12 , pp. 1069-1075
    • Wang, Y.1    Becker, D.2
  • 34
    • 0029915461 scopus 로고    scopus 로고
    • Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia
    • Cayuela, J-M., Madani, A., Sanhes, L., Stern, M-H., and Sigaux F. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood, 87: 2180-2186, 1996.
    • (1996) Blood , vol.87 , pp. 2180-2186
    • Cayuela, J.-M.1    Madani, A.2    Sanhes, L.3    Stern, M.-H.4    Sigaux, F.5
  • 36
    • 0028971677 scopus 로고
    • p16 proteins from melanoma-prone families are deficient in binding to Cdk4
    • Reymond, A., and Brent, R. p16 proteins from melanoma-prone families are deficient in binding to Cdk4. Oncogene, 11: 1173-1178, 1995.
    • (1995) Oncogene , vol.11 , pp. 1173-1178
    • Reymond, A.1    Brent, R.2
  • 37
    • 0029980941 scopus 로고    scopus 로고
    • Temperature sensitive mutants of p16/CDKN2 associated with familial melanoma
    • Parry, D., and Peters G. Temperature sensitive mutants of p16/CDKN2 associated with familial melanoma. Mol. Cell. Biol., 16: 3844-3852, 1996.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3844-3852
    • Parry, D.1    Peters, G.2
  • 38
    • 0022552131 scopus 로고
    • Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
    • Kozak, M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell, 44: 283-292, 1986.
    • (1986) Cell , vol.44 , pp. 283-292
    • Kozak, M.1
  • 39
    • 0023665902 scopus 로고
    • An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res., 15: 8125-8148, 1987.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 40
    • 0029990515 scopus 로고    scopus 로고
    • Cancer-associated missense and deletion mutations impair p16INK4 CDK inhibitory activity
    • Lilischkis, R., Sarcevic, B., Kennedy, C., Walters, A., and Sutherland, R. L. Cancer-associated missense and deletion mutations impair p16INK4 CDK inhibitory activity. Int. J. Cancer, 66: 249-254, 1996.
    • (1996) Int. J. Cancer , vol.66 , pp. 249-254
    • Lilischkis, R.1    Sarcevic, B.2    Kennedy, C.3    Walters, A.4    Sutherland, R.L.5
  • 42
    • 0028829571 scopus 로고
    • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage
    • Nakagawa, K., Conrad, N. K., Williams, J. P., Johnson, B. E., and Kelley, M. J. Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. Oncogene, 11: 1843-1851, 1995.
    • (1995) Oncogene , vol.11 , pp. 1843-1851
    • Nakagawa, K.1    Conrad, N.K.2    Williams, J.P.3    Johnson, B.E.4    Kelley, M.J.5
  • 43
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta, M., Bender, C. M., Yang, A. S., Nguyen, T., Beart, R. W., Van Tornout, J. M., and Jones, P. A. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55: 4531-4535, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 44
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman, J., Merlo, A., Mao, L., Lapidus, R. G., Issa J-P., Davidson, N. E., Sidransky, D., and Baylin, S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55: 4525-4530, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.-P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 45
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidransky, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
    • (1995) Nat. Med. , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 46
    • 85047679603 scopus 로고    scopus 로고
    • Status and expression of the p16INK4 gene in human thyroid tumors and thyroid-tumor cell lines
    • Calabro', V., Strazzullo, M., La Mantia, G., Fedele, M., Paulin, C., Fusco, A., and Lania, L. Status and expression of the p16INK4 gene in human thyroid tumors and thyroid-tumor cell lines. Int. J. Cancer, 67: 29-34, 1996.
    • (1996) Int. J. Cancer , vol.67 , pp. 29-34
    • Calabro', V.1    Strazzullo, M.2    La Mantia, G.3    Fedele, M.4    Paulin, C.5    Fusco, A.6    Lania, L.7
  • 49
    • 0028845853 scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16INK4, p15INK4B and p21WAF1/CIP1 in human breast cancer
    • Musgrove, E., Lilischkis, R., Cornish, A. L., Lee, C. S. L., Setlur, V., Seshadri, R., and Sutherland, R. L. Expression of the cyclin-dependent kinase inhibitor p16INK4, p15INK4B and p21WAF1/CIP1 in human breast cancer. Int. J. Cancer, 63: 584-591, 1995.
    • (1995) Int. J. Cancer , vol.63 , pp. 584-591
    • Musgrove, E.1    Lilischkis, R.2    Cornish, A.L.3    Lee, C.S.L.4    Setlur, V.5    Seshadri, R.6    Sutherland, R.L.7
  • 51
    • 0029880379 scopus 로고    scopus 로고
    • Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
    • Naumann, M., Savitskaia, N., Eilert, C., Schramm, A., Kalthoff, H., and Schmiegel, W. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology, 110: 1215-1224, 1996.
    • (1996) Gastroenterology , vol.110 , pp. 1215-1224
    • Naumann, M.1    Savitskaia, N.2    Eilert, C.3    Schramm, A.4    Kalthoff, H.5    Schmiegel, W.6
  • 52
    • 0030002649 scopus 로고    scopus 로고
    • Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells
    • Srivenugopal, K., and Ali-Osman, F. Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells. Oncogene, 12: 2029-2034, 1996.
    • (1996) Oncogene , vol.12 , pp. 2029-2034
    • Srivenugopal, K.1    Ali-Osman, F.2
  • 54
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/Cdk4-Rb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova, J., Lukas, J., Guldberg, P., Alsner, J., Kirkin, A. F., Zeuthen, J., and Bartec, J. The p16-cyclin D/Cdk4-Rb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res., 56: 5475-5483, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3    Alsner, J.4    Kirkin, A.F.5    Zeuthen, J.6    Bartec, J.7
  • 55
    • 23544472210 scopus 로고    scopus 로고
    • Virtually 100% of melanoma cell lines harbor alterations within the p16/p15 genes or one of their downstream targets
    • Walker, G. J., Flores, J. F., Glendening, J. M., You, E., Markl, I. D. C., and Fountain, J. W. Virtually 100% of melanoma cell lines harbor alterations within the p16/p15 genes or one of their downstream targets. Am. J. Hum. Genet., 59 (Suppl.): A6, 1996.
    • (1996) Am. J. Hum. Genet. , vol.59 , Issue.SUPPL.
    • Walker, G.J.1    Flores, J.F.2    Glendening, J.M.3    You, E.4    Markl, I.D.C.5    Fountain, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.