Towards a structural basis of human non-synonymous single nucleotide polymorphisms

Trends in Genetics

Volumn 16, Issue 5, 2000, Pages 198-200

  Sunyaev, Shamil ^a,b,c   Ramensky, Vasily ^a,b,c   Bork, Peer ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

DATA BASE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SHORT SURVEY;

EID: 0034191958     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(00)01988-0     Document Type: Article

References (17)

1. Collins F.S.et al. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res. 8:1998;1229-1231.
2. Halushka M.K.et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet. 22:1999;239-247.
3. Cargill M.et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. 22:1999;231-238.
4. Buetow K.H.et al. Reliable identification of large numbers of candidate SNPs from public EST data. Nat. Genet. 21:1999;323-325.
5. Sunyaev S.R.et al. Individual variation in protein-coding sequences of the human genome. Adv. Protein Chem. 2000;. (in press).
6. Li W.H. Molecular Evolution. 1997;Sinauer.
7. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
8. Collins F.S.et al. Variations on a theme: cataloging human DNA sequence variation. Science. 278:1997;1580-1581.
9. Lander E.S. The new genomics: global views of biology. Science. 274:1996;536-539.
10. Frishman D., Argos P. Knowledge-based protein secondary structure assignment. Proteins. 23:1995;566-579.
11. Bairoch A., Apweiler R. The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999. Nucleic Acids Res. 27:1999;49-54.
12. Sander C., Schneider R. Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins. 9:1991;56-68.
13. ™ (1999) Center for Medical Genetics, Johns Hopkins University, Baltimore, MD, and National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD. (http://www.ncbi.nlm.nih.gov/omim).
14. Brookes A.J.et al. HGBASE: a database of SNPs and other variations in and around human genes. Nucleic Acids Res. 28:2000;356-360.
15. Abola E.E.et al. Protein Data Bank archives of three-dimensional macromolecular structures. Methods Enzymol. 277:1997;556-571.
16. Kraulis P.J. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24:1991;946-950.
17. Merritt E.A., Bacon D.J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 277:1997;505-524.