Peroxisome-Proliferator-Activated Receptor (PPAR)-γ activation stimulates keratinocyte differentiation

Journal of Investigative Dermatology

Volumn 123, Issue 2, 2004, Pages 305-312

  Man, Mao Qiang ^a   Fowler, Ashley J ^a   Schmuth, Matthias ^b   Lau, Peggy ^a   Chang, Sandra ^a   Brown, Barbara E ^a,b   Moser, Arthur H ^b   Michalik, Liliane ^c   Desvergne, Beatrice ^c   Wahli, Walter ^c   Li, Mei ^d   Metzger, Daniel ^d   Chambon, Pierre H ^d   Elias, Peter M ^a   Feingold, Kenneth R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Inflammation; Nuclear hormone receptor; Permeability barrier function; Stratum corneum

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CIGLITAZONE; FILAGGRIN; INVOLUCRIN; LORICRIN; OXAZOLONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHORBOL 13 ACETATE 12 MYRISTATE; TROGLITAZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MEMBRANE; CONTROLLED STUDY; EPIDERMIS CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IRRITANT DERMATITIS; KERATINOCYTE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLERGY; SKIN PERMEABILITY; STRATUM CORNEUM; SURFACE PROPERTY;

EID: 3242690411     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23235.x     Document Type: Article

References (38)

1. Barak Y, Nelson MC, Ong ES, et al: PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 4:585-595, 1999
2. Basu-Modak S, Braissant O, Escher P, Desvergne B, Honegger P, Wahli W: Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase in reaggregated rat brain cell cultures. J Biol Chem 274:35881-35888, 1999
3. Brun RP, Kim JB, Hu E, Spiegelman BM: Peroxisome proliferator-activated receptor gamma and the control of adipogenesis. Curr Opin Lipidol 8:212-218, 1997
4. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM: PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 7:48-52, 2001a
5. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ: Nuclear receptors and lipid physiology: Opening the X-files. Science 294:1866-1870, 2001b
6. Desvergene B, Wahli W: Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocrinology 20:649-688, 1999
7. Di-Poi N, Tan NS, Michalik L, Wahli W, Desvergne B: Antiapoptotic role of PPAR-beta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 10:721-733, 2002
8. Eckert RL, Crish JF, Robinson NA: The epidermal keratinocyte as a model for the study of gene regulation and function. Physiol Rev 77:397-424, 1997
9. Elias PM, Feingold KR: Coordinate regulation of epidermal differentiation and barrier homeostasis. Skin Pharmacol Appl Skin Physiol 14 (Suppl 1): 28-34, 2001
10. Ellis CN, Varani J, Fisher GJ, et al: Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 136:609-616, 2000
11. Fowler AJ, Sheu MY, Kao J, et al: LXR activators display anti-inflammatory activity in irritant and allergic contact dermatitis models. J Invest Dermatol 120:246-255, 2003
12. Fuchs E: Epidermal differentiation. The bare essentials. J Cell Biol 111:2807-2814, 1990
13. Hanley K, Jiang Y, Crumrine D, et al: Activators of the nuclear hormone receptors PPAR-α and FXR accelerate the development of the fetal epidermal barrier. J Clin Invest 100:705-712, 1997
14. Hanley K, Jiang Y, He SS, et al: Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPAR-α. J Invest Dermatol 110:368-375, 1998
15. Hanley K, Ng DC, He SS, et al. Oxysterols induce differentiation in human keratinocytes and increase AP-1-dependent involucrin transcription. J Invest Dermatol 114:545-553, 2000
16. Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM: Membrane structures in normal and essential fatty acid-deficient stratum corneum: Characterization by ruthenium tetroxide staining and x-ray diffraction. J Invest Dermatol 96:215-223, 1991
17. Kliewer SA, Xu HE, Lambert MH, Willson TM: Peroxisome proliferator-activated receptors: From genes to physiology. Recent Prog Horm Res 56:239-263, 2001
18. Kliewer S, Lehman JM, Willson TM: Orphan nuclear receptors: Shifting endocrinology into reverse. Science 284:757-760, 1999
19. Komuves LG, Hanley K, Jiang Y, Elias PM, Williams ML, Feingold KR: Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. J Invest Dermatol 111:429-433, 1998
20. Komuves LG, Hanley K, Lefebvre AM, et al: Stimulation of PPARα promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol 115:353-360, 2000a
21. Komuves LG, Hanley K, Man MQ, Elias PM, Williams ML, Feingold KR: Keratinocyte differentiation in hyperprolferative epidermis: Topical application of PPARα restores tissue homeostasis. J Invest Dermatol 115:361-367, 2000b
22. Komuves LG, Schmuth M, Fowler AJ, et al: Oxysterol stimulation of epidermal differentiation is mediated by liver-X-receptor-B in murine epidermis. J Invest Dermatol 118:25-34, 2002
23. Kuenzli S, Saurat JH: Effect of topical PPARbeta/delta and PPARgamma agonists on plaque psoriasis. A pilot study. Dermatology 206:252-256, 2003
24. Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P: Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis. Nature 407:633-636, 2000
25. Lim H, Gupta RA, Ma WG, et al: Cyclooxygenase 2 derived prostacyclin mediates embryo implantation in the mouse via PPAR5. Genes Dev 13:1561-1574, 1999
26. Michalik L, Desvergne B, Tan NS, et al: Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta mutant mice. J Cell Biol 154:799-814, 2001
27. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ: Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93:693-704, 1998
28. Peters JM, Lee SS, Li W, et al: Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta (delta). Mol Cell Biol 20:5119-5128, 2000
29. Proksch E, Holleran WM, Menon GK, Elias PM, Feingold KR: Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol 128:473-482, 1993
30. Rivier M, Castiel I, Safonova I, Ailhaud G, Michel S: Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model. J Invest Dermatol 114:681-687, 2000
31. Rivier M, Safonova I, Lebrun P, Griffiths CE, Ailhaud G, Michel S: Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-1121, 1998
32. Schoonjans K, Staels B, Auwerx J: Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907-925, 1996
33. Schmuth M, Haqq CM, Cairns WJ, et al: Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-983, 2004
34. Sheu MY, Fowler AJ, Kao J, et al: Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol 118:94-101, 2002
35. Tan NS, Michalik L, Noy N, et al: Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev 15:3263-3277, 2001
36. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM: Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 18:113:159-70, 2003
37. Westergaard M, Henningsen J, Svendsen ML, et al: Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116:702-712, 2001
38. Yuspa SH, Kilkenny AE, Steinert PM, Roop DR: Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol 109:1207-1217, 1989