The cell cycle of early mammalian embryos: Lessons from genetic mouse models

Cell Cycle

Volumn 5, Issue 5, 2006, Pages 499-502

  Artus, Jérôme ^a   Babinet, Charles ^a   Cohen Tannoudji, Michel ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Checkpoints; Cyclin; Cyclin dependent kinases; Gene targeting; Mitosis; Ovum mutant candidate gene 1; Peri implantation lethality; Ubiquitin; Ubiquitin like

Indexed keywords

ATR PROTEIN; BUB3 PROTEIN; CHECKPOINT KINASE 1; CYCLIN A; CYCLIN B1; PROTEIN MAD2; PROTEIN UBC9; UBIQUITIN;

CELL COMPOSITION; CELL CYCLE REGULATION; EMBRYO CELL; EMBRYO DEVELOPMENT; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GENETIC CODE; HUMAN; MAMMAL; NONHUMAN; PLASTICITY; PREDICTION; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN MODIFICATION; REVIEW;

MAMMALIA;

EID: 33644756684     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.5.2500     Document Type: Review

References (42)

1. Davidson EH. Gene Activity in Early Development. Academic Press, 1986.
2. Mac Auley A, Werb Z, Mirkes PE. Characterization of the unusually rapid cell cycles during rat gastrulation. Development 1993; 117:873-83.
3. Snow MHL. Gastrulation in mouse - Growth and regionalization of epiblast. J Embryol Exp Morph 1977; 42:293-303.
4. Varmuza S, Prideaux V, Kothary R, Rossant J. Polytene chromosomes in mouse trophoblast giant cells. Development 1988; 102:127-34.
5. Hartwell LH, Weinert TA. Checkpoints: Controls that ensure the order of cell cycle events. Science 1989; 246:629-34.
6. Wang Q, Liu T, Fang Y, Xie S, Huang X, Mahmood R, Ramaswamy G, Sakamoto KM, Darzynkiewicz Z, Xu M, Dai W. BUBR1 deficiency results in abnormal megakaryopoiesis. Blood 2004; 103:1278-85.
7. Kalitsis P, Earle E, Fowler KJ, Choo KH. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev 2000; 14:2277-82.
8. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 2000; 101:635-45.
9. Howman EV, Fowler KJ, Newson AJ, Redward S, MacDonald AC, Kalitsis P, Choo KH. Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. Proc Natl Acad Sci USA 2000; 97:1148-53.
10. Kalitsis P, Fowler KJ, Earle E, Hill J, Choo KH. Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. Proc Natl Acad Sci USA 1998; 95:1136-41.
11. Putkey FR, Cramer T, Morphew MK, Silk AD, Johnson RS, McIntosh JR, Cleveland DW. Unstable kinetochoremicrotubule capture and chromosomal instability following deletion of CENP-E. cDev Cell 2002; 3:351-65.
12. Cutts SM, Fowler KJ, Kile BT, Hii LL, O'Dowd RA, Hudson DF, Saffery R, Kalitsis P, Earle E, Choo KH. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Hum Mol Genet 1999; 8:1145-55.
13. Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol 2000; 10:1319-28.
14. 2/M DNA damage checkpoint. Genes Dev 2000; 14:1448-59.
15. Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000; 14:1439-47.
16. Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14:397-402.
17. Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, Campos-Torres J, Leder P. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci USA 1996; 93:13084-9.
18. Larsen E, Gran C, Saether BE, Seeberg E, Klungland A. Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage. Mol Cell Biol 2003; 23:5346-53.
19. Dumon-Jones V, Frappart PO, Tong WM, Sajithlal G, Hulla W, Schmid G, Herceg Z, Digweed M, Wang ZQ. Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res 2003; 63:7263-9.
20. Tsuzuki T, Fujii Y, Sakumi K, Tominaga Y, Nakao K, Sekiguchi M, Matsushiro A, Yoshimura Y, Morita T. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci USA 1996; 93:6236-40.
21. Yonemasu R, Minami M, Nakatsu Y, Takeuchi M, Kuraoka I, Matsuda Y, Higashi Y, Kondoh H, Tanaka K. Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality. DNA Repair (Amst) 2005; 4:479-91.
22. de Boer J, Donker I, de Wit J, Hoeijmakers JH, Weeda G. Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality. Cancer Res 1998; 58:89-94.
23. Ku KY, Voytek P. The effects of U.V.-light, ionizing radiation and the carcinogen N-acetoxy-2-fluorenylacetamide on the development in vitro of one- and two-cell mouse embryos. Int J Radiat Biol Relat Stud Phys Chem Med 1976; 30:401-8.
24. Spindle A, Nagano H, Pedersen RA. Inhibition of DNA replication in preimplantation mouse embryos by aphidicolin. J Exp Zool 1985; 235:289-95.
25. Otaegui PJ, O'Neill GT, Campbell KH, Wilmut I. Transfer of nuclei from 8-cell stage mouse embryos following use of nocodazole to control the cell cycle. Mol Reprod Dev 1994; 39:147-52.
26. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, Rideout WM, Bronson RT, Gardner H, Sicinski P. Cyclin E ablation in the mouse. Cell 2003; 114:431-43.
27. Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S, Dubus P, Barbacid M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004; 118:493-504.
28. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P. Mouse development and cell proliferation in the absence of D-cyclins. Cell 2004; 118:477-91.
29. Martin A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M, Barbacid M. Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell 2005; 7:591-8.
30. Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J, Gannon J, Hunt T. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc Natl Acad Sci USA 1998; 95:4344-9.
31. Winston N, Bourgain-Guglielmetti F, Ciemerych MA, Kubiak JZ, Senamaud-Beaufort C, Carrington M, Brechot C, Sobczak-Thepot J. Early development of mouse embryos null mutant for the cyclin A2 gene occurs in the absence of maternally derived cyclin A2 gene products. Dev Biol 2000; 223:139-53.
32. Pravtcheva DD, Wise TL. Disruption of Apc10/Doc1 in three alleles of oligosyndactylism. Genomics 2001; 72:78-87.
33. Magnuson T, Epstein CJ. Oligosyndactyly: A lethal mutation in the mouse that results in mitotic arrest very early in development. Cell 1984; 38:823-33.
34. Wirth KG, Ricci R, Gimenez-Abian JF, Taghybeeglu S, Kudo NR, Jochum W, Vasseur-Cognet M, Nasmyth K. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev 2004; 18:88-98.
35. Nacerddine K, Lehembre F, Bhaumik M, Artus J, Cohen-Tannoudji M, Babinet C, Pandolfi PP, Dejean A. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell 2005; 9:769-79.
36. Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M. Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Curr Biol 1999; 9:1191-4.
37. Singer JD, Gurian-West M, Clurman B, Roberts JM. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev 1999; 13:2375-87.
38. Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol 2003; 23:6790-7.
39. Tateishi K, Omata M, Tanaka K, Chiba T. The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J Cell Biol 2001; 155:571-9.
40. Li T, Inoue A, Lahti JM, Kidd VJ. Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Mol Cell Biol 2004; 24:3188-97.
41. Le Cam L, Lacroix M, Ciemerych MA, Sardet C, Sicinski P. The E4F protein is required for mitotic progression during embryonic cell cycles. Mol Cell Biol 2004; 24:6467-75.
42. Artus J, Vandormael-Pournin S, Frodin M, Nacerddine K, Babinet C, Cohen-Tannoudji M. Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionary conserved nuclear protein. Mol Cell Biol 2005; 25:6289-302.