Genetic screening for susceptibility to depression: Can we and should we?

Australian and New Zealand Journal of Psychiatry

Volumn 38, Issue 1-2, 2004, Pages 73-80

  Morley, Katherine I ^a   Hall, Wayne D ^a   Carter, Lucy ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Depression; Ethics; Genetic screening; Genetics

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CATECHOL METHYLTRANSFERASE; SEROTONIN TRANSPORTER; TYROSINE 3 MONOOXYGENASE;

ADOLESCENT; ALLELE; BIPOLAR DEPRESSION; CHILD; DEPRESSION; FAMILY; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR DEPRESSION; MEDICAL ETHICS; MEDLINE; MOOD DISORDER; POLICY; PRACTICE GUIDELINE; PSYCINFO; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT;

GENETICS AND REPRODUCTION;

ADOLESCENT; ADULT; ALLELES; BIPOLAR DISORDER; CARRIER PROTEINS; CATECHOL O-METHYLTRANSFERASE; CHILD; DEPRESSIVE DISORDER, MAJOR; GENETIC PREDISPOSITION TO DISEASE; GENETIC PRIVACY; GENETIC SCREENING; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; RISK ASSESSMENT; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TYROSINE 3-MONOOXYGENASE;

EID: 1842475961     PISSN: 00048674     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1614.2004.01300.x     Document Type: Review

References (57)

1. Duffy A, Grof P, Robertson C, Alda M. The implications of genetic studies of major mood disorders for clinical practice. Journal of Clinical Psychiatry 2000; 61:630-637.
2. Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry 2000; 157:1552-1562.
3. Gershon ES. Bipolar illness and schizophrenia as oligogenic diseases: Implications for the future. Biological Psychiatry 2000; 47:240-244.
4. Kelsoe JR, Spence MA, Loetscher E et al. A genome survey indicates a posible susceptibility locus for bipolar disorder on chromosome 22. Proceedings of the National Academy of Sciences of the United States of America 2001; 98:585-590.
5. Kendler KS. Twin studies of psychiatric illness. Archives of General Psychiatry 2001; 58:1005-1014.
6. Souery D, Rivelli SK, Mendlewicz J. Molecular genetic and family studies in affective disorders: State of the art. Journal of Affective Disorders 2001; 62:45-55.
7. Gershon ES, Kelsoe JR, Kendler KS, Watson JD. A scientific opportunity. Science 2001; 294:957.
8. Beauchamp TL, Childress JF. Principles of biomedical ethics. Oxford: Oxford University Press, 2001.
9. Brody BA. The ethics of biomedical research: An international perspective. New York: Oxford University Press, 1998.
10. Craddock N, Dave S, Greening J. Association studies of bipolar disorder. Bipolar Disorders 2001; 3:284-298.
11. Kendler KS, Prescott CA. A population-based twin study of lifetime major depression in men and women. Archives of General Psychiatry 1999; 56:39-44.
12. Malhi GS, Moore J, McGuffin P. The genetics of major depressive disorder. Current Psychiatry Reports 2000; 2:165-169.
13. Kendler KS, Thornton LM, Gardner CO. Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. American Journal of Psychiatry 2001; 158:582-586.
14. Kendler KS, Pedersen NL, Neale MC, Mathe AA. A pilot Swedish twin study of affective illness including hospital- and population-ascertained subsamples: Results of model fitting. Behavior Genetics 1995; 25:217-232.
15. Marazita ML, Neiswanger K, Cooper M et al. Genetic segregation analysis of early-onset recurrent unipolar depression. American Journal of Human Genetics 1997; 61:1370-1378.
16. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265:2037-2047.
17. Schork NJ. Genetic of complex disease. Approaches, problems, and solutions. American Journal of Respiratory and Critical Care Medicine 1997; 156:S103-S109.
18. Burmeister M. Basic concepts in the study of diseases with complex genetics. Biological Psychiatry 1999; 45:522-532.
19. Kato T. Molecular genetics of bipolar disorder. Neuroscience Research 2001; 40:105-113.
20. Furlong RA, Ho L, Walsh C et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. American Journal of Medical Genetics 1998; 81:58-63.
21. Ogilvie AD, Battersby S, Bubb VJ et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347:731-733.
22. Stoeber G, Heils A, Lesch KP. Serotonin transporter gene polymorphism and affective disorder. Lancet 1996; 347:1340-1341.
23. Furlong RA, Rubinsztein JS, Ho L et al. Analysis and meta-analysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders. American Journal of Medical Genetics 1999; 88:88-94.
24. Biomed European Bipolar Collaborative Group. No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. British Journal of Psychiatry 1997; 170:526-528.
25. Craddock N, Jones I. Molecular genetics of bipolar disorder. British Journal of Psychiatry 2001; 178(Suppl. 41):s128-s133.
26. Lim LC, Powell JF, Murray R, Gill M. Monoamine oxidase A gene and bipolar affective disorder. American Journal of Human Genetics 1994; 54:1122-1124.
27. Berrettini W. Review of bipolar molecular linkage and association studies. Current Psychiatry Reports 2002; 4:124-129.
28. Furlong RA, Ho L, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter. American Journal of Medical Genetics 1999; 88:398-406.
29. Preisig M, Bellivier F, Fenton BT et al. Association between bipolar disorder and monoamine oxidase A gene polymorphisms: Results of a multicenter study. American Journal of Psychiatry 2000; 157:948-955.
30. Baldessarini RJ. A plea for integrity of the bipolar disorder concept. Bipolar Disorders 2000; 2:3-7.
31. Duffy A, Grof P. Psychiatric diagnoses in the context of genetic studies of bipolar disorder. Bipolar Disorders 2001; 3:270-275.
32. Kirmayer LJ. Cultural variations in the clinical presentation of depression and anxiety: Implications for diagnosis and treatment. Journal of Clinical Psychiatry 2001; 62:22-28.
33. Weeks DE, Lathrop GM. Polygenic disease: Methods for mapping complex disease traits. Trends in Genetics 1995; 11:513-519.
34. Collins FS. Shattuck lecture: Medical and social consequences of the Human Genome. New England Journal of Medicine 1990; 341:28-37.
35. Coyle JT. Childhood mood disorders: Unmet needs but important opportunities. Biological Psychiatry 2001; 49:959.
36. Lewis L. Unmet needs in diagnosis and treatment of mood disorders in children and adolescents. Biological Psychiatry 2001; 49:960-961.
37. Nuffield Council on Bioethics. Mental Disorders and Genetics: the Ethical Context London: Nuffield Council on Bioethics, 1998.
38. Stevenson DA, Strasburger VC. Advice or consent? Issues in genetic testing of adolescents. Adolescent Medicine 2002; 13:213-221.
39. Lessick M, Faux S. Implications of genetic testing of children and adolescents. Holistic Nursing Practice 1998; 12:38-46.
40. Fost N. Ethical issues in research and innovative therapy in children with mood disorders. Biological Psychiatry 2001; 49:1015-1022.
41. Andrews G, Sanderson K, Slade T, Issakidis C. Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bulletin of the World Health Organization 2000; 78:446-454.
42. Hickie IB. Responding to the Australian experience of depression. Medical Journal of Australia 2002; 176:S61-S62.
43. McNair BG, Highet NJ, Hickie IB, Davenport T, A. Exploring the perspectives of people whose lives have been affected by depression. Medical Journal of Australia 2002; 176:S69-S76.
44. Jorm AF, Medway J, Christensen H, Korten AE, Jacomb PA, Rodgers B. Public beliefs about the helpfulness of interventions for depression: Effects on actions taken when experiencing anxiety and depression symptoms. Australian and New Zealand Journal of Psychiatry 2000; 34:619-626.
45. Cohen CB. Wrestling with the future: Should we test children for adult-onset genetic conditions. Kennedy Institute of Ethics Journal 1998; 8:111-130.
46. Wertz DC, Fanos JH, Reilly PR. Genetic testing for children and adolescents: Who decides? Journal of the American Medical Association 1994; 272:875-881.
47. Wiggins S, Whyte P, Huggins M et al. The psychological consequences of predictive testing for Huntington's disease. New England Journal of Medicine 1992; 327:1401-1405.
48. Marteau TM, Croyle RT. The new genetics: Psychological responses to genetic testing. British Medical Journal 1998; 316:693-697.
49. Wertz DC. Testing children and adolescents. In: Burley J, Harris J eds. A companion to genethics. Oxford: Blackwell, 2002: 92-113.
50. Australian Law Reform Commission, Australian Health Ethics Committee. Protection of Human Genetic Information: Issues Paper. Canberra: Australian Law Reform Commission, 2001.
51. Alexander JR, Lerer B, Baron M. Ethical issues in genetic linkage studies of psychiatric disorders. British Journal of Psychiatry 1992; 160:98-102.
52. Parker LS. Ethical issues in bipolar disorders pedigree research: Privacy concerns, informed consent, and grounds for waiver. Bipolar Disorders 2002; 4:1-16.
53. National Health and Medical Research Council. Ethical Aspects of Human Genetic Testing: An Information Paper. Canberra: National Health and Medical Research Council, 2000.
54. Collier DA, Arranz MJ, Sham P et al. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 1996; 7:1675-1679.
55. Rees M, Norton N, Jones I et al. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Molecular Psychiatry 1997; 2:398-402.
56. Ohara K, Nagai M, Suzuki Y. Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression. Neuroreport 1998; 9:1305-1308.
57. Qian Y, Lin S, Jiang S et al. Studies of the DXS7 polymorphism at the MAO loci in unipolar depression. American Journal of Medical Genetics 1999; 88:598-600.