Exposure to inorganic arsenic metabolites during early human development

Toxicological Sciences

Volumn 44, Issue 2, 1998, Pages 185-190

  Concha, Gabriela ^a   Vogler, Gerardo ^b   Lezcano, Dora ^b   Nermell, Barbro ^a   Vahter, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Hospital San Antonio de Los Cobres   (Argentina)

Author keywords

Drinking water; Exposure; Fetus; Metabolite; Methylation; Plasma

Indexed keywords

ARSENIC; DRINKING WATER;

ARTICLE; BREAST MILK; CLINICAL ARTICLE; CONGENITAL MALFORMATION; FEMALE; HUMAN; METHYLATION; ORGANOGENESIS; PRENATAL EXPOSURE; UMBILICAL CORD BLOOD; URINE LEVEL;

EID: 0031696147     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2486     Document Type: Article

References (47)

1. Aposhian, H. V., Zakharyan, R., Wu, Y., Healy, S., and Aposhian, M. M. (1997). Enzymatic methylation of arsenic compounds: II. An overview. In Arsenic: Exposure and Health Effects (C. O. Abernathy, R. L. Calderon, and W. R. Chappell, Eds.), pp. 298-321. Chapman & Hall, London/New York.
2. Aschengrau, A., Zierler, S., and Cohen, A. (1989). Quality of community drinking water and occurrence of spontaneous abortion. Arch. Environ. Health 44, 283-290.
3. Beaudoin, A. R. (1974). Teratogenicity of sodium arsenate in rats. Teratology 10, 153-157.
4. Bennet, W. C. (1947). The Atacameño. In Handbook of Southamerican Indians (J. H. Steward, Ed.), Vol. 2, p. 599. Smithsonian Institution, Bureau of American Ethnology, Washington, DC.
5. Bolliger, C. T., van Zijl, P., and Louw, J. (1992). Multiple organ failure with the adult respiratory distress syndrome in homicidal arsenic poisoning. Respiration 59, 57-61.
6. Börzsönyi, M., Bereczky, A., Rudnai, P., Csanady, M., and Horvath, A. (1992). Epidemiological studies on human subjects exposed to arsenic in drinking water in southeast Hungary. Arch. Toxicol. 66, 77-78.
7. Buchet, J. P., Lauwerys, R., and Roels, H. (1981a). Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int. Arch. Occup. Environ. Health 48, 71-79.
8. Buchet, J. P., Lauwerys, R., and Roels, H. (1981b). Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers. Int. Arch. Occup. Environ. Health 48, 111-118.
9. Chen, C. J., Chen, C. W., Wu, M. M., and Kuo, T. L. (1992). Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 66, 888-892.
10. Concha, G., Nermell, B., and Vahter, M. (1998a). Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ. Health Perspect., 106, 355-359.
11. Concha, G., Vogler, G., Nermell, B., and Vahter, M. (1998b). Low-level arsenic excretion in breast milk of native Andean women exposed to high levels of arsenic in the drinking water. Int. Arch. Occup. Environ. Health 71, 42-46.
12. Edmonds, J. S., and Francesconi, K. A. (1987). Transformations of arsenic in the marine environment. Experientia 43, 553-557.
13. Ferm, V. G., and Hanlon, D. P. (1985). Constant rate of exposure of pregnant hamster to arsenate during early gestation. Environ. Res. 37, 425-432.
14. Ferm, V. H., Saxon, A., and Smith, B. M. (1971). The teratogenic profile of sodium arsenate in the golden hamster. Arch. Environ. Health 22, 557-560.
15. Foà, V., Colombi, A., and Maroni, M. (1984). The speciation of the chemical forms of arsenic in the biological monitoring of exposure to inorganic arsenic. Sci. Total Environ. 34, 241-259.
16. Golub, M. S. (1994). Maternal toxicity and the identification of inorganic arsenic as a developmental toxicant. Reprod. Toxicol. 8, 283-295.
17. Hood, R. D., and Bishop, S. L. (1972). Teratogenic effects of sodium arsenate in mice. Arch. Environ. Health 24, 62-65.
18. Hood, R. D., Harrison, W. P., and Vedel, G. C. (1982). Evaluation of arsenic metabolites for prenatal effects in the hamster. Bull. Environ. Contam. Toxicol. 29, 679-687.
19. Hood, R. D., Thaker, G. T., and Patterson, B. L. (1978). Prenatal effects of oral versus intraperitoneal sodium arsenate in mice. J. Environ. Pathol. Toxicol. 1, 857-864.
20. Hopenhayn-Rich, C., Smith, A. H., and Goeden, H. M. (1993). Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic. Environ. Res. 60, 161-177.
21. Jaenisch, R. (1997). DNA methylation and imprinting: Why bother? Trends Genet. 13, 323-329.
22. Kagey, B. T., Bumgarner, J. E., and Creason, J. P. (1977). Arsenic levels in maternal-fetal tissues sets. In Trace Substances in Environmental Health XI: A Symposium (D. D. Hemphill, Ed.), pp. 252-256. Univ. of Missouri Press, Columbia.
23. Lugo, G., Cassady, G., and Palmisano, P. (1969). Acute maternal arsenic. Am. J. Dis. Child. 117, 328-330.
24. Marafante, E., Vahter, M., Norin, H., Envall, J., Sandström, M., Christakopoulos, A., and Ryhage, R. (1987). Biotransformation of dimethylarsinic acid in mouse, hamster and man. J. Appl. Toxicol. 7, 111-117.
25. Moore, M. M., Harrington-Brock, K., and Doerr, C. L. (1997). Relative genotoxic potency of arsenic and its methylated metabolites. Mutat. Res. 386, 279-290.
26. Morrissey, R. E., and Mottet, N. K. (1983). Arsenic-induced exencephaly in the mouse and associated lesions occurring during neurulation. Teratology 28, 399-411.
27. Nagymajtenyi, L., Selypes, A., and Berencsi, G. (1985). Chromosomal aberrations and fetotoxic effects of atmospheric arsenic exposure in mice. J. Appl. Toxicol. 5, 61-63.
28. Nordström, S., Beckman, L., and Nordenson, I. (1979a). Occupational and environmental risk in and around a smelter in northern Sweden: V. Spontaneous abortion among female employees and decreased birth weight in their offspring. Hereditas 90, 291-296.
29. Nordström, S., Beckman, L., and Nordenson, I. (1979b). Occupational and environmental risk in and around a smelter in northern Sweden: VI. Congenital malformations. Hereditas 90, 297-302.
30. Paik, M. K., Lee, K-H., Hson, S-S., Park, I-M., Hong, J-H., and Hwang, B-D. (1991). Human placental protein methylase: I. Purification and characterization. Int. J. Biochem. 23, 939-945.
31. Rogers, E. H., Chernoff, N., and Kavlock, R. J. (1981). The teratogenic potential of cacodylic acid in the rat and mouse. Drug Chem. Toxicol. 4, 49-61.
32. Smith, A. H., Hopenhayn-Rich, C., Bates, M. N., Goeden, H. M., Hertz-Picciotto, I., Duggan, H. M., Wood, R., Kosnett, M. J., and Smith, M. T. (1992). Cancer risks from arsenic in drinking water. Environ. Health Perspect. 97, 259-267.
33. Tabacova, S., Baird, D. D., Balabaeva, L., Lolova, D., and Petrov, I. (1994). Placental arsenic and cadmium in relation to lipid peroxides and glutathione levels in maternal-infant pairs from a copper smelter area. Placenta 15, 873-881.
34. Tam, G. K. H., and Conacher, H. B. S. (1977). The suitability of the dry ashing procedure for determination of arsenic in marine samples. J. Environ. Sci. Health B 12, 213-227.
35. Tam, G. K. H., and Lacroix, G. (1982). Dry ashing hydride generation atomic absorption spectrometric determination of arsenic and selenium in food. J. Assoc. Off. Anal. Chem. 65, 647-650.
36. 74As. Anal. Biochem. 86, 505-511.
37. U.S. EPA (1988). Special report on ingested inorganic arsenic: Skin cancer; nutritional essentiality, EPA 625/3-87/013. U.S. Environmental Protection Agency, Washington, DC.
38. Vahter, M., and Lind, B. (1986). Concentrations of arsenic in urine of the general population in Sweden. Sci. Total Environ. 54, 1-12.
39. Vahter, M., and Marafante, E. (1985). Reduction and binding of arsenate in marmoset monkeys. Arch. Toxicol. 57, 119-124.
40. Vahter, M., and Marafante, E. (1988). In vivo methylation and detoxication of arsenic. In The Biological Alkylation of Heavy Metals (P. J. Craig and F. Glockling, Eds.), pp. 105-119. Roy. Soc. of Chem., London.
41. Vahter, M., Concha, G., Nermell, B., Nilsson, R., Dulout, F., and Natarajan, A. T. (1995a). A unique metabolism of inorganic arsenic in native Andean women. Eur. J. Pharmacol. 293, 455-462.
42. Vahter, M., Couch, R., Nermell, B., and Nilsson, R. (1995b). Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol. Appl. Pharmacol. 133, 262-268.
43. Vahter, M., Marafante, E., and Dencker, L. (1983). Metabolism of arsenobetaine in mice, rats and rabbits. Sci. Total Environ. 30, 197-211.
44. 74As-dimethylarsinic acid in mice and rats. Arch. Environ. Contam. Toxicol. 13, 259-264.
45. Willhite, C. C., and Ferm, V. H. (1984). Prenatal and developmental toxicology of arsenicals. In Nutritional and Toxicological Aspects of Food Safety (M. Friedman, Ed.), pp. 205-228. Plenum, New York.
46. Yamauchi, H., Takahashi, K., Mashiko, M., Saitoh, J., and Yamamura, Y. (1992). Intake of different chemical species of dietary arsenic by Japanese, and their blood and urinary arsenic levels. Appl. Organomet. Chem. 6, 383-388.
47. Zierler, S., Theodore, M., Cohen, A., and Rothman, J. (1988). Chemical quality of maternal drinking water and congenital heart disease. Int. J. Epidemiol. 17, 589-594.