메뉴 건너뛰기




Volumn 1, Issue 2, 2004, Pages 81-89

Virological significance, prevalence and genetic basis of hypersusceptibility to nonnucleoside reverse transcriptase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 33644692514     PISSN: 14485028     EISSN: None     Source Type: Journal    
DOI: 10.1071/SH03012     Document Type: Review
Times cited : (4)

References (69)
  • 1
    • 0022996630 scopus 로고
    • Phosphorylation of 3′-azido-3prime;-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase
    • Furman PA, Fyfe JA, St Clair MH, Weinhold K, Rideout JL, Freeman GA, et al. Phosphorylation of 3′-azido-3prime;-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci USA 1986; 83(21): 8333-7.
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.21 , pp. 8333-8337
    • Furman, P.A.1    Fyfe, J.A.2    St Clair, M.H.3    Weinhold, K.4    Rideout, J.L.5    Freeman, G.A.6
  • 2
    • 0032437454 scopus 로고    scopus 로고
    • The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
    • doi: 10.1016/S0166-3542(98)00025-4
    • De Clercq E. The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. Antiviral Res 1998; 38(3): 153-79. doi: 10.1016/S0166-3542(98)00025-4
    • (1998) Antiviral Res , vol.38 , Issue.3 , pp. 153-179
    • De Clercq, E.1
  • 3
    • 0033940444 scopus 로고    scopus 로고
    • Incidence and impact of resistance against approved antiretroviral drugs
    • doi: 10.1002/1099-1654(200007/08) 10:4<231::AID-RMV290>3.3.CO;2-G
    • Pillay D, Taylor S, Richman DD. Incidence and impact of resistance against approved antiretroviral drugs. Rev Med Virol 2000; 10(4): 231-53. doi: 10.1002/1099-1654(200007/08) 10:4<231::AID-RMV290>3.3.CO;2-G
    • (2000) Rev Med Virol , vol.10 , Issue.4 , pp. 231-253
    • Pillay, D.1    Taylor, S.2    Richman, D.D.3
  • 4
    • 0034446565 scopus 로고    scopus 로고
    • The genetic basis of HIV-1 resistance to reverse transcriptase and protease inhibitors
    • Shafer RW, Kantor R, Gonzales MJ. The genetic basis of HIV-1 resistance to reverse transcriptase and protease inhibitors. AIDS Rev 2000; 2: 211-28.
    • (2000) AIDS Rev , vol.2 , pp. 211-228
    • Shafer, R.W.1    Kantor, R.2    Gonzales, M.J.3
  • 5
    • 0035876456 scopus 로고    scopus 로고
    • Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: Impact on virological response to efavirenz-based therapy
    • doi: 10.1097/00002030-200106150-00007
    • Shulman N, Zolopa AR, Passaro D, Shafer RW, Huang W, Katzenstein D, et al. Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy. AIDS 2001; 15(9): 1125-32. doi: 10.1097/00002030-200106150-00007
    • (2001) AIDS , vol.15 , Issue.9 , pp. 1125-1132
    • Shulman, N.1    Zolopa, A.R.2    Passaro, D.3    Shafer, R.W.4    Huang, W.5    Katzenstein, D.6
  • 6
    • 0037131303 scopus 로고    scopus 로고
    • Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: Clinical, phenotypic and genotypic correlates
    • doi: 10.1097/00002030-200210180-00002
    • Whitcomb JM, Huang W, Limoli K, Paxinos E, Wrin T, Skowron G, et al. Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates. AIDS 2002; 16(15): F41-7. doi: 10.1097/00002030-200210180-00002
    • (2002) AIDS , vol.16 , Issue.15
    • Whitcomb, J.M.1    Huang, W.2    Limoli, K.3    Paxinos, E.4    Wrin, T.5    Skowron, G.6
  • 7
    • 18344409610 scopus 로고    scopus 로고
    • The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: A prospective cohort analysis
    • doi: 10.1097/00002030-200210180-00001
    • Haubrich RH, Kemper CA, Hellmann NS, Keiser PH, Witt MD, Forthal DN, et al. The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis. AIDS 2002; 16(15): F33-40. doi: 10.1097/00002030-200210180-00001
    • (2002) AIDS , vol.16 , Issue.15
    • Haubrich, R.H.1    Kemper, C.A.2    Hellmann, N.S.3    Keiser, P.H.4    Witt, M.D.5    Forthal, D.N.6
  • 8
    • 0037055027 scopus 로고    scopus 로고
    • Dual vs single protease inhibitor therapy following antiretroviral treatment failure: A randomized trial
    • doi: 10.1001/JAMA.288.2.169
    • Hammer SM, Vaida F, Bennett KK, Holohan MK, Sheiner L, Eron JJ, et al. Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial. JAMA 2002; 288(2): 169-80. doi: 10.1001/JAMA.288.2.169
    • (2002) JAMA , vol.288 , Issue.2 , pp. 169-180
    • Hammer, S.M.1    Vaida, F.2    Bennett, K.K.3    Holohan, M.K.4    Sheiner, L.5    Eron, J.J.6
  • 9
    • 0037626084 scopus 로고    scopus 로고
    • Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs
    • doi: 10.1097/00002030-200304110-00007
    • Katzenstein DA, Bosch RJ, Hellmann N, Wang N, Bacheler L, Albrecht MA. Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs. AIDS 2003; 17(6): 821-30. doi: 10.1097/00002030-200304110-00007
    • (2003) AIDS , vol.17 , Issue.6 , pp. 821-830
    • Katzenstein, D.A.1    Bosch, R.J.2    Hellmann, N.3    Wang, N.4    Bacheler, L.5    Ma, A.6
  • 11
    • 0026693137 scopus 로고
    • Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 1992; 256(5065): 1783-90.
    • (1992) Science , vol.256 , Issue.5065 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 12
    • 0028925773 scopus 로고
    • Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
    • Spence RA, Kati WM, Anderson KS, Johnson KA. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 1995; 267(5200): 988-93.
    • (1995) Science , vol.267 , Issue.5200 , pp. 988-993
    • Spence, R.A.1    Kati, W.M.2    Anderson, K.S.3    Johnson, K.A.4
  • 13
    • 0029150042 scopus 로고
    • Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
    • Rittinger K, Divita G, Goody RS. Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. Proc Natl Acad Sci USA 1995; 92(17): 8046-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.17 , pp. 8046-8049
    • Rittinger, K.1    Divita, G.2    Goody, R.S.3
  • 14
    • 0029644484 scopus 로고
    • Structure of HIV-1 reverse transcriptase in a complex with the non- Nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution
    • Ding J, Das K, Tantillo C, Zhang W, Clark AD, Jr, Jessen S, et al. Structure of HIV-1 reverse transcriptase in a complex with the non- nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution. Structure 1995; 3(4): 365-79.
    • (1995) Structure , vol.3 , Issue.4 , pp. 365-379
    • Ding, J.1    Das, K.2    Tantillo, C.3    Zhang, W.4    Clark Jr., A.D.5    Jessen, S.6
  • 15
    • 0028924567 scopus 로고
    • Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
    • Esnouf R, Ren J, Ross C, Jones Y, Stammers D, Stuart D. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nat Struct Biol 1995; 2(4): 303-8.
    • (1995) Nat Struct Biol , vol.2 , Issue.4 , pp. 303-308
    • Esnouf, R.1    Ren, J.2    Ross, C.3    Jones, Y.4    Stammers, D.5    Stuart, D.6
  • 16
    • 0035912717 scopus 로고    scopus 로고
    • Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase
    • doi: 10.1073/PNAS.121055998
    • Tachedjian G, Orlova M, Sarafianos SG, Arnold E, Goff SP. Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Proc Natl Acad Sci USA 2001; 98(13): 7188-93. doi: 10.1073/PNAS.121055998
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.13 , pp. 7188-7193
    • Tachedjian, G.1    Orlova, M.2    Sarafianos, S.G.3    Arnold, E.4    Goff, S.P.5
  • 17
    • 0141515727 scopus 로고    scopus 로고
    • The effect of NNRTIs on HIV reverse transcriptase dimerization
    • Tachedjian G, Goff SP. The effect of NNRTIs on HIV reverse transcriptase dimerization. Curr Opin Investig Drugs 2003; 4(8): 966-73.
    • (2003) Curr Opin Investig Drugs , vol.4 , Issue.8 , pp. 966-973
    • Tachedjian, G.1    Goff, S.P.2
  • 18
    • 0024832408 scopus 로고
    • Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative
    • Baba M, Tanaka H, De Clercq E, Pauwels R, Balzarini J, Schols D, et al. Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. Biochem Biophys Res Commun 1989; 165(3): 1375-81.
    • (1989) Biochem Biophys Res Commun , vol.165 , Issue.3 , pp. 1375-1381
    • Baba, M.1    Tanaka, H.2    De Clercq, E.3    Pauwels, R.4    Balzarini, J.5    Schols, D.6
  • 19
    • 0025014499 scopus 로고
    • Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
    • doi: 10.1038/343470A0
    • Pauwels R, Andries K, Desmyter J, Schols D, Kukla MJ, Breslin HJ, et al. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature 1990; 343(6257): 470-4. doi: 10.1038/343470A0
    • (1990) Nature , vol.343 , Issue.6257 , pp. 470-474
    • Pauwels, R.1    Andries, K.2    Desmyter, J.3    Schols, D.4    Kukla, M.J.5    Breslin, H.J.6
  • 20
    • 0035292858 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance
    • doi: 10.1097/00042560-200103011-00004
    • Deeks SG. International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance. J Acquir Immune Defic Syndr 2001; 26(Suppl 1): S25-33. doi: 10.1097/00042560-200103011-00004
    • (2001) J Acquir Immune Defic Syndr , vol.26 , Issue.1 SUPPL.
    • Deeks, S.G.1
  • 21
    • 0035138694 scopus 로고    scopus 로고
    • The emerging roles of non-nucleoside reverse transcriptase inhibitors in antiretroviral therapy
    • Moyle G. The emerging roles of non-nucleoside reverse transcriptase inhibitors in antiretroviral therapy. Drugs 2001; 61(1): 19-26.
    • (2001) Drugs , vol.61 , Issue.1 , pp. 19-26
    • Moyle, G.1
  • 22
    • 0033576816 scopus 로고    scopus 로고
    • Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team
    • doi: 10.1056/NEJM199912163412501
    • Staszewski S, Morales-Ramirez J, Tashima KT, Rachlis A, Skiest D, Stanford J, et al. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. N Engl J Med 1999; 341(25): 1865-73. doi: 10.1056/NEJM199912163412501
    • (1999) N Engl J Med , vol.341 , Issue.25 , pp. 1865-1873
    • Staszewski, S.1    Morales-Ramirez, J.2    Tashima, K.T.3    Rachlis, A.4    Skiest, D.5    Stanford, J.6
  • 23
    • 0032565098 scopus 로고    scopus 로고
    • A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine forHIV-infected patients: the INCAS Trial. Italy
    • The Netherlands Can Aust Study. doi: 10.1001/JAMA.279.12.930
    • Montaner JS, Reiss P, Cooper D, Vella S, Harris M, Conway B, et al. A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands Can Aust Study. J Am Med Assoc 1998; 279(12): 930-7. doi: 10.1001/JAMA.279.12.930
    • (1998) J Am Med Assoc , vol.279 , Issue.12 , pp. 930-937
    • Montaner, J.S.1    Reiss, P.2    Cooper, D.3    Vella, S.4    Harris, M.5    Conway, B.6
  • 24
    • 0038369913 scopus 로고    scopus 로고
    • A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients
    • doi: 10.1097/00002030-200305020-00007
    • van Leeuwen R, Katlama C, Murphy RL, Squires K, Gatell J, Horban A, et al. A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients. AIDS 2003; 17(7): 987-99. doi: 10.1097/00002030-200305020-00007
    • (2003) AIDS , vol.17 , Issue.7 , pp. 987-999
    • Van Leeuwen, R.1    Katlama, C.2    Murphy, R.L.3    Squires, K.4    Gatell, J.5    Horban, A.6
  • 25
    • 0035071409 scopus 로고    scopus 로고
    • An open-label randomized trial to evaluate different therapeutic strategies of combination therapy in HIV-1 infection: Design, rationale, and methods of the initio trial
    • doi: 10.1016/S0197-2456(00)00123-9
    • Anon. An open-label randomized trial to evaluate different therapeutic strategies of combination therapy in HIV-1 infection: design, rationale, and methods of the initio trial. Control Clin Trials 2001; 22(2): 160-75. doi: 10.1016/S0197-2456(00)00123-9
    • (2001) Control Clin Trials , vol.22 , Issue.2 , pp. 160-175
  • 26
    • 0033816183 scopus 로고    scopus 로고
    • Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: Results of Adult AIDS Clinical Trials Group protocol 370
    • doi: 10.1097/00002030-200007280-00011
    • Kuritzkes DR, Bassett RL, Johnson VA, Marschner IC, Eron JJ, Sommadossi JP, et al. Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370. AIDS 2000; 14(11): 1553-61. doi: 10.1097/00002030-200007280-00011
    • (2000) AIDS , vol.14 , Issue.11 , pp. 1553-1561
    • Kuritzkes, D.R.1    Bassett, R.L.2    Johnson, V.A.3    Marschner, I.C.4    Eron, J.J.5    Sommadossi, J.P.6
  • 27
    • 0035833452 scopus 로고    scopus 로고
    • Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection
    • doi: 10.1056/NEJM200108093450602
    • Albrecht MA, Bosch RJ, Hammer SM, Liou SH, Kessler H, Para MF, et al. Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection. N Engl J Med 2001; 345(6): 398-407. doi: 10.1056/NEJM200108093450602
    • (2001) N Engl J Med , vol.345 , Issue.6 , pp. 398-407
    • Albrecht, Ma.1    Bosch, R.J.2    Hammer, S.M.3    Liou, S.H.4    Kessler, H.5    Para, M.F.6
  • 28
    • 0033941373 scopus 로고    scopus 로고
    • Clinical uses of non-nucleoside reverse transcriptase inhibitors
    • doi: 10.1002/1099-1654(200007/08)10:4<217::AIDRMV279>3.3.CO;2-C
    • Harris M, Montaner JS. Clinical uses of non-nucleoside reverse transcriptase inhibitors. Rev Med Virol 2000; 10(4): 217-29. doi: 10.1002/1099-1654(200007/08)10:4<217::AIDRMV279>3.3.CO;2-C
    • (2000) Rev Med Virol , vol.10 , Issue.4 , pp. 217-229
    • Harris, M.1    Montaner, J.S.2
  • 30
    • 0025679303 scopus 로고
    • Science 1990; 250(4986): 1411-3.
    • (1990) Science , vol.250 , Issue.4986 , pp. 1411-1413
  • 32
    • 0028785708 scopus 로고
    • L-743, 726 (DMP-266): A novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
    • Young SD, Britcher SF, Tran LO, Payne LS, Lumma WC, Lyle TA, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 1995; 39(12): 2602-5.
    • (1995) Antimicrob Agents Chemother , vol.39 , Issue.12 , pp. 2602-2605
    • Young, S.D.1    Britcher, S.F.2    Tran, L.O.3    Payne, L.S.4    Lumma, W.C.5    Lyle, T.A.6
  • 33
    • 0027957791 scopus 로고
    • Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy
    • Richman DD, Havlir D, Corbeil J, Looney D, Ignacio C, Spector SA, et al. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J Virol 1994; 68(3): 1660-6.
    • (1994) J Virol , vol.68 , Issue.3 , pp. 1660-1666
    • Richman, D.D.1    Havlir, D.2    Corbeil, J.3    Looney, D.4    Ignacio, C.5    Spector, S.A.6
  • 34
    • 0036104758 scopus 로고    scopus 로고
    • Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: Past, present, and future perspectives
    • Campiani G, Ramunno A, Maga G, Nacci V, Fattorusso C, Catalanotti B, et al. Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives. Curr Pharm Des 2002; 8(8): 615-57.
    • (2002) Curr Pharm des , vol.8 , Issue.8 , pp. 615-657
    • Campiani, G.1    Ramunno, A.2    Maga, G.3    Nacci, V.4    Fattorusso, C.5    Catalanotti, B.6
  • 35
    • 12944314948 scopus 로고    scopus 로고
    • Efavirenz- And adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologie response
    • Shulman NS, Zolopa AR, Passaro DJ, Murlidharan U, Israelski DM, Brosgart CL, et al. Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologie response. J Acquir Immune Defic Syndr 2000; 23(3): 221-6.
    • (2000) J Acquir Immune Defic Syndr , vol.23 , Issue.3 , pp. 221-226
    • Shulman, N.S.1    Zolopa, A.R.2    Passaro, D.J.3    Murlidharan, U.4    Israelski, D.M.5    Brosgart, C.L.6
  • 38
    • 0028172345 scopus 로고
    • Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance
    • doi: 10.1006/JMBI.1994.1665
    • Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, et al. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J Mol Biol 1994; 243(3): 369-87. doi: 10.1006/JMBI.1994.1665
    • (1994) J Mol Biol , vol.243 , Issue.3 , pp. 369-387
    • Tantillo, C.1    Ding, J.2    Jacobo-Molina, A.3    Nanni, R.G.4    Boyer, P.L.5    Hughes, S.H.6
  • 39
    • 13144282707 scopus 로고    scopus 로고
    • doi: 10.1006/JMBI.1998.2171
    • Hsiou Y, Das K, Ding J, Clark AD, Jr, Kleim JP, Rosner M, et al. Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. J Mol Biol 1998; 284(2): 313-23. doi: 10.1006/JMBI.1998.2171
    • (1998) J Mol Biol , vol.284 , Issue.2 , pp. 313-323
    • Hsiou, Y.1    Das, K.2    Ding, J.3    Clark Jr., A.D.4    Kleim, J.P.5    Rosner, M.6
  • 40
    • 0035368238 scopus 로고    scopus 로고
    • The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
    • doi: 10.1006/JMBI.2001.4648
    • Hsiou Y, Ding J, Das K, Clark AD, Jr, Boyer PL, Lewi P, et al. The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J Mol Biol 2001; 309(2): 437-45. doi: 10.1006/JMBI.2001.4648
    • (2001) J Mol Biol , vol.309 , Issue.2 , pp. 437-445
    • Hsiou, Y.1    Ding, J.2    Das, K.3    Clark Jr., A.D.4    Boyer, P.L.5    Lewi, P.6
  • 41
    • 0033621167 scopus 로고    scopus 로고
    • Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids
    • doi: 10.1073/PNAS.96.18.10027
    • Sarafianos SG, Das K, Clark AD, Jr, Ding J, Boyer PL, Hughes SH, et al. Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Proc Natl Acad Sci USA 1999; 96(18): 10027-32. doi: 10.1073/PNAS.96.18.10027
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.18 , pp. 10027-10032
    • Sarafianos, S.G.1    Das, K.2    Clark Jr., A.D.3    Ding, J.4    Boyer, P.L.5    Hughes, S.H.6
  • 42
    • 0032506055 scopus 로고    scopus 로고
    • Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
    • doi: 10.1021/BI981200E
    • Arion D, Kaushik N, McCormick S, Borkow G, Parniak MA. Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 1998; 37(45): 15908-17. doi: 10.1021/BI981200E
    • (1998) Biochemistry , vol.37 , Issue.45 , pp. 15908-15917
    • Arion, D.1    Kaushik, N.2    McCormick, S.3    Borkow, G.4    Ma, P.5
  • 43
    • 0033165851 scopus 로고    scopus 로고
    • A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
    • Meyer PR, Matsuura SE, Mian AM, So AG, Scott WA. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol Cell 1999; 4(1): 35-43.
    • (1999) Mol Cell , vol.4 , Issue.1 , pp. 35-43
    • Meyer, P.R.1    Matsuura, S.E.2    Mian, A.M.3    So, A.G.4    Scott, W.A.5
  • 44
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder BA, Kemp SD. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 1989; 246(4934): 1155-8.
    • (1989) Science , vol.246 , Issue.4934 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 45
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
    • Kellam P, Boucher CA, Larder BA. Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc Nail Acad Sci USA 1992; 89(5): 1934-8.
    • (1992) Proc Nail Acad Sci USA , vol.89 , Issue.5 , pp. 1934-1938
    • Kellam, P.1    Boucher, C.A.2    Larder, B.A.3
  • 46
    • 10244227943 scopus 로고    scopus 로고
    • An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3′-azido-3′-deoxythymidine
    • Hooker DJ, Tachedjian G, Solomon AE, Gurusinghe AD, Land S, Birch C, et al. An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3′-azido-3′-deoxythymidine. J Virol 1996; 70(11): 8010-8.
    • (1996) J Virol , vol.70 , Issue.11 , pp. 8010-8018
    • Hooker, D.J.1    Tachedjian, G.2    Solomon, A.E.3    Gurusinghe, A.D.4    Land, S.5    Birch, C.6
  • 47
    • 0142042463 scopus 로고    scopus 로고
    • Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates
    • doi: 10.1086/378281
    • Whitcomb JM, Parkin NT, Chappey C, Hellmann NS, Petropoulos CJ. Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates. J Infect Dis 2003; 188(7): 992-1000. doi: 10.1086/378281
    • (2003) J Infect Dis , vol.188 , Issue.7 , pp. 992-1000
    • Whitcomb, J.M.1    Parkin, N.T.2    Chappey, C.3    Hellmann, N.S.4    Petropoulos, C.J.5
  • 48
    • 0028940084 scopus 로고
    • Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
    • Shirasaka T, Kavlick MF, Ueno T, Gao WY, Kojima E, Alcaide ML, et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci USA 1995; 92(6): 2398-402.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.6 , pp. 2398-2402
    • Shirasaka, T.1    Kavlick, M.F.2    Ueno, T.3    Gao, W.Y.4    Kojima, E.5    Alcaide, M.L.6
  • 49
    • 0032817241 scopus 로고    scopus 로고
    • A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance
    • Larder BA, Bloor S, Kemp SD, Hertogs K, Desmet RL, Miller V, et al. A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Antimicrob Agents Chemother 1999; 43(8): 1961-7.
    • (1999) Antimicrob Agents Chemother , vol.43 , Issue.8 , pp. 1961-1967
    • Larder, B.A.1    Bloor, S.2    Kemp, S.D.3    Hertogs, K.4    Desmet, R.L.5    Miller, V.6
  • 50
    • 0033552832 scopus 로고    scopus 로고
    • Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs
    • doi: 10.1097/00002030-199901140-00010
    • de Jong JJ, Goudsmit J, Lukashov VV, Hillebrand ME, Baan E, Huismans R, et al. Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs. AIDS 1999; 13(1): 75-80. doi: 10.1097/00002030-199901140-00010
    • (1999) AIDS , vol.13 , Issue.1 , pp. 75-80
    • Jong, J.J.1    Goudsmit, J.2    Lukashov, V.V.3    Hillebrand, M.E.4    Baan, E.5    Huismans, R.6
  • 51
    • 0032533207 scopus 로고    scopus 로고
    • A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors
    • Winters MA, Coolley KL, Girard YA, Levee DJ, Hamdan H, Shafer RW, et al. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. J Clin Invest 1998; 102(10): 1769-75.
    • (1998) J Clin Invest , vol.102 , Issue.10 , pp. 1769-1775
    • Winters, Ma.1    Coolley, K.L.2    Girard, Y.A.3    Levee, D.J.4    Hamdan, H.5    Shafer, R.W.6
  • 52
    • 0026454435 scopus 로고
    • 3′-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors
    • Larder BA. 3′-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 1992; 36(12): 2664-9.
    • (1992) Antimicrob Agents Chemother , vol.36 , Issue.12 , pp. 2664-2669
    • Larder, B.A.1
  • 53
    • 0028333887 scopus 로고
    • Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors
    • Byrnes VW, Emini EA, Schleif WA, Condra JH, Schneider CL, Long WJ, et al. Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors. Antimicrob Agents Chemother 1994; 38(6): 1404-7.
    • (1994) Antimicrob Agents Chemother , vol.38 , Issue.6 , pp. 1404-1407
    • Byrnes, V.W.1    Emini, E.A.2    Schleif, W.A.3    Condra, J.H.4    Schneider, C.L.5    Long, W.J.6
  • 54
    • 0029792446 scopus 로고    scopus 로고
    • Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet
    • Tachedjian G, Mellors J, Bazmi H, Birch C, Mills J. Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet. J Virol 1996; 70(10): 7171-81.
    • (1996) J Virol , vol.70 , Issue.10 , pp. 7171-7181
    • Tachedjian, G.1    Mellors, J.2    Bazmi, H.3    Birch, C.4    Mills, J.5
  • 55
    • 0038234808 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel
    • doi: 10.1086/375597
    • Hirsch MS, Brun-Vezinet F, Clotet B, Conway B, Kuritzkes DR, D'Aquila RT, et al. Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel. Clin Infect Dis 2003; 37(1): 113-28. doi: 10.1086/375597
    • (2003) Clin Infect Dis , vol.37 , Issue.1 , pp. 113-128
    • Hirsch, M.S.1    Brun-Vezinet, F.2    Clotet, B.3    Conway, B.4    Kuritzkes, D.R.5    D'Aquila, R.T.6
  • 56
    • 0034019566 scopus 로고    scopus 로고
    • A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1
    • doi: 10.1128/AAC.44.4.920-928.2000
    • Petropoulos CJ, Parkin NT, Limoli KL, Lie YS, Wrin T, Huang W, et al. A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother 2000; 44(4): 920-8. doi: 10.1128/AAC.44.4.920-928.2000
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.4 , pp. 920-928
    • Petropoulos, C.J.1    Parkin, N.T.2    Limoli, K.L.3    Lie, Y.S.4    Wrin, T.5    Huang, W.6
  • 57
    • 0002634626 scopus 로고    scopus 로고
    • Laboratory atVR. Validation of the performance characteristics of a novel, rapid phenotypic drug susceptibility assay, PhenoSense HIV
    • Hellmann N, Johnson P, Petropoulos C. Laboratory atVR. Validation of the performance characteristics of a novel, rapid phenotypic drug susceptibility assay, PhenoSense HIV Antivir Ther 1999; 4(Suppl. 1):34.
    • (1999) Antivir Ther , vol.4 , Issue.1 SUPPL. , pp. 34
    • Hellmann, N.1    Johnson, P.2    Petropoulos, C.3
  • 58
    • 0942290559 scopus 로고    scopus 로고
    • Natural variation of drug susceptibility in wild-type human immunodeficiency virus type 1
    • doi: 10.1128/AAC.48.2.437-443.2004
    • Parkin NT, Hellmann NS, Whitcomb JM, Kiss L, Chappey C, Petropoulos CJ. Natural variation of drug susceptibility in wild-type human immunodeficiency virus type 1. Antimicrob Agents Chemother 2004; 48(2): 437-43. doi: 10.1128/AAC.48.2.437-443.2004
    • (2004) Antimicrob Agents Chemother , vol.48 , Issue.2 , pp. 437-443
    • Parkin, N.T.1    Hellmann, N.S.2    Whitcomb, J.M.3    Kiss, L.4    Chappey, C.5    Petropoulos, C.J.6
  • 59
    • 0036190937 scopus 로고    scopus 로고
    • Prevalence of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated mutations and polymorphisms in NNRTI-naive HIV-infected patients
    • Clevenbergh P, Cua E, Dam E, Durant J, Schmit JC, Boulme R, et al. Prevalence of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated mutations and polymorphisms in NNRTI-naive HIV-infected patients. HIV Clin Trials 2002; 3(1): 36-44.
    • (2002) HIV Clin Trials , vol.3 , Issue.1 , pp. 36-44
    • Clevenbergh, P.1    Cua, E.2    Dam, E.3    Durant, J.4    Schmit, J.C.5    Boulme, R.6
  • 60
    • 0037661154 scopus 로고    scopus 로고
    • Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1
    • doi: 10.1097/00002030-200306130-00026
    • Moreno S, Casado JL, Perez-Elias MJ, Dronda F, Antela A, Moreno A, et al. Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1. AIDS2003; 17(9): 1413-4. doi: 10.1097/00002030-200306130-00026
    • (2003) AIDS , vol.17 , Issue.9 , pp. 1413-1414
    • Moreno, S.1    Casado, J.L.2    Perez-Elias, M.J.3    Dronda, F.4    Antela, A.5    Moreno, A.6
  • 61
    • 0037227866 scopus 로고    scopus 로고
    • Correlation of phenotypic zidovudine resistance with mutational patterns in the reverse transcriptase of human immunodeficiency virus type 1: Interpretation of established mutations and characterization of new polymorphisms at codons 208, 211, and 214
    • doi: 10.1128/AAC.47.1.54-61.2003
    • Sturmer M, Staszewski S, Doerr HW, Larder B, Bloor S, Hertogs K. Correlation of phenotypic zidovudine resistance with mutational patterns in the reverse transcriptase of human immunodeficiency virus type 1: interpretation of established mutations and characterization of new polymorphisms at codons 208, 211, and 214. Antimicrob Agents Chemother 2003; 47(1): 54-61. doi: 10.1128/AAC.47.1.54-61.2003
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.1 , pp. 54-61
    • Sturmer, M.1    Staszewski, S.2    Doerr, H.W.3    Larder, B.4    Bloor, S.5    Hertogs, K.6
  • 62
    • 0035822981 scopus 로고    scopus 로고
    • World-wide variation in HIV-1 phenotypic susceptibility in untreated individuals: Biologically relevant values for resistance testing
    • doi: 10.1097/00002030-200109070-00010
    • Harrigan PR, Montaner JS, Wegner SA, Verbiest W, Miller V, Wood R, et al. World-wide variation in HIV-1 phenotypic susceptibility in untreated individuals: biologically relevant values for resistance testing. AIDS 2001; 15(13): 1671-7. doi: 10.1097/00002030-200109070-00010
    • (2001) AIDS , vol.15 , Issue.13 , pp. 1671-1677
    • Harrigan, P.R.1    Montaner, J.S.2    Wegner, S.A.3    Verbiest, W.4    Miller, V.5    Wood, R.6
  • 63
    • 0035037383 scopus 로고    scopus 로고
    • Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy
    • doi: 10.1128/JVI.75.11.4999-5008.2001
    • Bacheler L, Jeffrey S, Hanna G, D'Aquila R, Wallace L, Logue K, et al. Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy. J Virol 2001; 75(11): 4999-5008. doi: 10.1128/JVI.75.11.4999-5008.2001
    • (2001) J Virol , vol.75 , Issue.11 , pp. 4999-5008
    • Bacheler, L.1    Jeffrey, S.2    Hanna, G.3    D'Aquila, R.4    Wallace, L.5    Logue, K.6
  • 64
    • 0027318776 scopus 로고
    • Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0. A resolution shows bent DNA
    • Jacobo-Molina A, Ding J, Nanni RG, Clark AD, Jr, Lu X, Tantillo C, et al. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0. A resolution shows bent DNA. Proc Natl Acad Sci USA 1993; 90(13): 6320-4.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.13 , pp. 6320-6324
    • Jacobo-Molina, A.1    Ding, J.2    Nanni, R.G.3    Clark Jr., A.D.4    Lu, X.5    Tantillo, C.6
  • 65
    • 0028842293 scopus 로고
    • The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
    • Rodgers DW, Gamblin SJ, Harris BA, Ray S, Culp JS, Hellmig B, et al. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1995; 92(4): 1222-6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.4 , pp. 1222-1226
    • Rodgers, D.W.1    Gamblin, S.J.2    Harris, B.A.3    Ray, S.4    Culp, J.S.5    Hellmig, B.6
  • 66
    • 0032573488 scopus 로고    scopus 로고
    • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
    • doi: 10.1126/SCIENCE.282.5394.1669
    • Huang H, Chopra R, Vereine GL, Harrison SC. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 1998; 282(5394): 1669-75. doi: 10.1126/SCIENCE.282.5394.1669
    • (1998) Science , vol.282 , Issue.5394 , pp. 1669-1675
    • Huang, H.1    Chopra, R.2    Vereine, G.L.3    Harrison, S.C.4
  • 67
    • 0034612275 scopus 로고    scopus 로고
    • Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase
    • doi: 10.1073/PNAS.97.12.6334
    • Tachedjian G, Aronson HE, Goff SP. Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase. Proc Natl Acad Sci USA 2000; 97(12): 6334-9. doi: 10.1073/PNAS.97.12.6334
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.12 , pp. 6334-6339
    • Tachedjian, G.1    Aronson, H.E.2    Goff, S.P.3
  • 68
    • 0035970694 scopus 로고    scopus 로고
    • Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype
    • doi: 10.1097/00002030-200103300-00003
    • Van Laethem K, Witvrouw M, Pannecouque C, Van Remoortel B, Schmit JC, Esnouf R, et al. Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype. AIDS 2001; 15(5): 553-61. doi: 10.1097/00002030-200103300-00003
    • (2001) AIDS , vol.15 , Issue.5 , pp. 553-561
    • Van Laethem, K.1    Witvrouw, M.2    Pannecouque, C.3    Van Remoortel, B.4    Schmit, J.C.5    Esnouf, R.6
  • 69
    • 11544277817 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
    • doi: 10.1073/PNAS.95.16.9518
    • Ren J, Esnouf RM, Hopkins AL, Jones EY, Kirby I, Keeling J, et al. 3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Proc Natl Acad Sci USA 1998; 95(16): 9518-23. doi: 10.1073/PNAS.95.16.9518
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.16 , pp. 9518-9523
    • Ren, J.1    Esnouf, R.M.2    Hopkins, A.L.3    Jones, E.Y.4    Kirby, I.5    Keeling, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.