Objective functional assessment of age-related maculopathy: A special application for the multifocal electroretinogram

Clinical and Experimental Optometry

Volumn 88, Issue 5, 2005, Pages 304-312

  Feigl, Beatrix ^a,b   Lovie Kitchin, Jan ^b   Brown, Brian ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Age related maculopathy; Multifocal electroretinogram; Objective function

Indexed keywords

DISEASE COURSE; ELECTROOCULOGRAPHY; ELECTRORETINOGRAPHY; HOSPITALIZATION; HUMAN; METHODOLOGY; PATHOPHYSIOLOGY; RETINA; RETINA MACULA DEGENERATION; REVIEW;

DISEASE PROGRESSION; ELECTROOCULOGRAPHY; ELECTRORETINOGRAPHY; HUMANS; MACULAR DEGENERATION; RETINA; SEVERITY OF ILLNESS INDEX;

EID: 33644670057     PISSN: 08164622     EISSN: 14440938     Source Type: Journal    
DOI: 10.1111/j.1444-0938.2005.tb06714.x     Document Type: Review

References (88)

1. Mitchell P, Wang J, Foran S, Smith W. The five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. Ophthalmology 2002;109:1092-1097. (Pubitemid 34546916)
2. Mukesh B, Dimitrov P, Leikin S, Wang J, Mitchell P, McCarty C, Taylor HR. Five-year incidence of age-related maculopathy: the Visual Impairment Project. Ophthalmology 2004;111:1176-1182. (Pubitemid 38736997)
3. Taylor H, Keeffe J, Vu H, Wang J, Rochtchina E, Pezzullo M, Mitchell P. Vision loss in Australia. Med J Aust 2005;182:565-568.
4. Brown M, Brown G, Stein J, Beauchchamp G. Age-related macular degneration: economic burden and value-based medicine analysis. Can J Ophthalmol 2005;40:277-287. (Pubitemid 40942254)
5. Klein R, Klein B, Linton K. Prevalence of age-related maculopathy. Ophthalmology 1992;99:933-943.
6. Ghafour M, Allen D, Foulds W. Common causes of blindness and visual handicap in the West of Scotland. Br J Ophthalmol 1983;67:209-213.
7. van Leeuwen R, Klaver C, Vingerling J, Hofman A, de Jong P. The risk and natural course of age-related maculopathy. Followup at 6 1/2 years in the Rotterdam Study. Arch Ophthalmol 2003;121:519-526.
8. Smith D, Assink J, Klein R, Mitchell P, Klaver C, Klein BE, Hofman A, Jensen S, Wang J, de Jong P. Risk factors for agerelated macular degeneration: Pooled findings from three continents. Ophthalmology
9. Bird A. Age-related macular disease: an ongoing challenge. Clin Exp Ophthalmol 2003;31:461-463. (Pubitemid 38049220)
10. Curcio C, Medeiros N, Millican L. Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci 1996;37:1236-1249.
11. Owsley C, Jackson G, White M, Edwards D. Delays in rod-mediated dark-adaptation in early age-related maculopathy. Ophthalmology 2001;108:1196-1202.
12. Phipps J, Dang T, Vingrys A, Guymer R. Flicker perimetry losses in age-related macular degeneration. Invest Ophthalmol Vis Sci 2004;45:3355-3360. (Pubitemid 39121876)
13. Phipps J, Guymer R, Vingrys A. Loss of cone function in age-related maculopathy. Invest Ophthalmol Vis Sci 2003;44:2277-2283.
14. Phipps J, Guymer R, Vingrys AJ. Temporal sensitivity deficits in patients with high-risk drusen. Aust NZ J Ophthalmol. 1999;27:265-267.
15. Cheng A, Vingrys A. Visual losses in early age-related maculopathy. Optom Vis Sci 1992;70:89-96.
16. Eisner A, Stoumbos V, Klein M, Fleming A. Relation between fundus appearance and function. Eyes whose fellow eye has exudative age-related macular degeneration. Invest Ophthalmol Vis Sci 1991;32:8-20.
17. Eisner A, Fleming A, Klein M, Mauldin W. Sensitivities in older eyes with good acuity: eyes whose fellow eye has exudative AMD. Invest Ophthalmol Vis Sci 1987;28:1832-1837.
18. Eisner A, Klein M, Zilis J, Watkins M. Visual function and the subsequent development of exudative age-related macular degeneration. Invest Ophthalmol Vis Sci 1992;33:3091-3102.
19. Midena E, Degli A, Blarzino M, Valenti M, Segato T. Macular function impairment in eyes with early age-related macular degeneration. Invest Ophthalmol Vis Sci 1997;38:469-477.
20. Feigl B, Brown B, Lovie-Kitchin J, Swann P. Cone-and rod-mediated mfERG in early age-related maculopathy. Eye 2005;19:431-441.
21. Feigl B, Brown B, Lovie-Kitchin J, Swann P. Cone-mediated multifocal electroretinogram in early age-related maculopathy and its relationships with subjective macular function tests. Curr Eye Res 2004;29:327-336.
22. Feigl B, Brown B, Lovie-Kitchin J, Swann P. Monitoring retinal function in early agerelated maculopathy: visual performance after one year. Eye 2004; advanced online publication.
23. Chen C, Wu L, Wu D, Huang S, Wen F, Luo G, Long S. The local cone and rod system function in early age-related macular degeneration. Doc Ophthalmol 2004;109:1-8.
24. Karpe G, Rickenbach K, Thomasson S. The clinical electroretinogram: I. The normal electroretinogram above 50 years of age. Acta Ophthalmol Scand 1950;28:301-305.
25. Nilsson S, Skoog K. Covariation of the simultanously recorded c-wave and standing potential of the human eye. Acta Ophthalmol Scand 1975;53:721-730.
26. Sunness J, Massof R, Johnson M, Finkelstein D, Fine S. Peripheral retinal function in age-related maculopathy. Arch Ophthalmol 1985;103:811-816.
27. Holopigian K, Seiple W, Greenstein V, Kim D, Carr R. Relative effects of aging and agerelated macular degeneration on peripheral visual function. Optom Vis Sci 1997;74:152-159.
28. Marcus M, Merin S, Wolf M, Feinsod M. Electrophysiological tests in assessment of senile macular degeneration. Ann Ophthalmol 1983;15:235-238.
29. Merin S, Auerbach E. The central and peripheral retina in macular degenerations. Arch Ophthalmol 1970;84:710-718.
30. Wu L. The characteristic electroretinogram anomalies in age-related macular degeneration [Article in Chinese]. Zhonghua Yan Ke Za Zhi 1991;27:197-199.
31. Henkes H. ERG in circulatory disturbances of the retina. III. ERG in cases of senile degeneration of the macular area. Arch Ophthalmol 1954;51:54-66.
32. Niemeyer G. Elektroretinographie bei Makuladegeneration. Graefe's Arch Clin Exp Ophthalmol 1969;177:39-51.
33. Walter P, Widder R, Lueke C, Koenigsfeld P, Brunner R. Electrophysiological abnormalities in age-related macular degeneration. Graefe's Arch Clin Exp Ophthalmol 1999;237:962-968.
34. Jackson C, McGwin G, Phillips J, Klein R, Owsley C. Impact of aging and age-related maculopathy on activation of the a-wave of the rod-mediated electroretinogram. Invest Ophthalmol Vis Sci 2004;45:3271-3278.
35. Sandberg M, Ariel M. A hand-held two channel stimulator ophthalmoscope. Arch Ophthalmol 1977;95:1881-1882.
36. Arden G, Banks J. Foveal electroretinogram as a clinical test. Br J Ophthalmol 1966;50:740.
37. Biersdorf W, Diller D. Local electroretinogram in macular degeneration. Am J Ophthalmol 1969;68:269-303.
38. Aiba T, Alpern M, Maaseidvaag F. The electroretinogram evoked by excitation of human foveal cones. J Physiol 1967;189:43-62.
39. Jones R, King-Smith P, Loffing D, Gaynier F. Stray light contributions to the focal electroretinogram (ERG). Clin Vis Sci 1986;1:153-160.
40. Yamamoto S, Gouras P, Lopez R. The focal cone electroretinogram. Vision Res 1995;35:1641-1649.
41. Seiple W, Siegel I, Carr R, Mayron C. Evaluating macular function using the focal ERG. Invest Ophthalmol Vis Sci 1986;27:1123-1130.
42. Seiple W, Siegel I, Carr R, Mayron C. Objective assessment of modulation transfer functions using the focal ERG. Am J Ophthalmol 1986;63:1-6.
43. Falsini B, Fadda A, Iarossi G, Piccardi M, Canu D, Minnella A, Serrao S, Scullica L. Retinal sensitivity to flicker modulation: reduced by early age-related maculopathy. Invest Ophthalmol Vis Sci 2003;41:1498-1506.
44. Miyake Y, Yanagida K, Kondo M, Yagasaki K, Ohta I. Subjective scotometry and recording of local electroretinogram and visual evoked response system with television monitor of the fovea. Jap J Ophthalmol 1981;25:438-448.
45. Sandberg M, Miller S, Gaudio A. Foveal cone ERGs in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 1993;34:3477-3480.
46. Remulla J, Gaudio AR, Miller S, Sandberg M. Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular agerelated macular degeneration. Br J Ophthalmol 1995;79:558-561.
47. Mayer M, Ward B, Klein R, Talcott J, Dougherty R, Glucs A. Flicker sensitivity and fundus appearance in pre-exudative age-related maculopathy. Invest Ophthalmol Vis Sci 1994;35:1138-1149.
48. Falsini B, Focosi F, Molle F, Manganelli C, Iarossi G, Fadda A, Dorin G, Mainster M. Monitoring retinal function during transpupillary thermotherapy for occult choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci 2003;44:2133-2140.
49. Falsini B, Piccardi M, Iarossi G, Fadda A, Merendino E, Valentini P. Influence of shortterm antioxidant supplementation on macular function in age-related maculopathy. Ophthalmology 2003;110:51-61.
50. Sutter E, Tran D. The field topography of ERG components in man-I. The photopic luminance response. Vision Res 1992;32:433-446.
51. Hood D. Assessing retinal function with the multifocal technique. Prog Ret Eye Res 2000;19:607-646.
52. Palmowski A, Sutter E, Bearse M, Fung W. Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram. Invest Ophthalmol Vis Sci 1997;38:2586-2596.
53. Hood D, Frishman L, Saszik S, Viswanathan S. Retinal origins of the primate multifocal ERG. Implication for the human response. Invest Ophthalmol Vis Sci 2002;43:1673-1685.
54. Hood D, Seiple W, Holopigian K, Greenstein V. A comparison of the components of the multifocal and full-field ERGs. Vis Neurosci 1997;14:533-544.
55. Li J, Tso M, Lam T. Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration. Br J Ophthalmol 2001;85:287-290.
56. Huang S, Wu D, Jiang F, Ma J, Wu L, Liang J, Luo G. The multifocal electroretinogram in age-related maculopathies. Doc Ophthalmol 2000;101:115-124.
57. Gerth C, Hause D, Delahunt P, Morse L, Werner J. Assessment of multifocal electroretinogram abnormalities and their relation to morphologic characteristics with large drusen. Arch Ophthalmol 2003;121:1404-1414.
58. Bearse M, Sutter E. Imaging localized retinal dysfunction with the multifocal electroretinogram. J Opt Soc Am A 1996;13:634-640.
59. Palmowski A, Sutter E, Bearse M, Fung W. Multifocal electroretinogram (MF-ERG) in diagnosis of macular changes. Example: senile macular degeneration [in German]. Ophthalmologe 1999;96:166-173.
60. Jurklies B, Weismann M, Sutter E, Bornfeld N. Monitoring retinal function in neovascular maculopathy using multifocal electroretinography-early-and long-term correlation with clinical findings. Graefe's Arch Clin Exp Ophthalmol 2002;240:244-264.
61. Seeliger M, Jurklies B, Kellner U, Palmowski A, Bach M, Kretschmann U. Multifocal electroretinography (mfERG) [in German]. Ophthalmologe 2001;98:1112-1129.
62. Palmowski A, Allgayer R, Heinemann-Vernaleken B, Ruprecht K. First and second order changes in the multifocal electroretinogram of patients with different forms of age related macular degeneration. In: Vision Science and its Application. OSA Tech Dig Ser, Optical Society of America, Washington, DC: 2001. p 32-35.
63. Heinemann-Vernaleken B, Palmowski A, Allgayer R, Ruprecht K. Comparison of different high resolution multifocal electroretinogram recordings in patients with age-related maculopathy. Graefe's Arch Clin Exp Ophthalmol 2001;239:556-561.
64. Curcio C. Photoreceptor topography in aging and age-related maculopathy. Eye 2001;15:376-383.
65. Owsley C, Jackson G, Cideciyan A, Huang Y, Fine S, Ho A, Marguire M, Lolley V, Jacobson S. Psychophysical evidence for rod vulnerability in age-related macular degeneration. Invest Ophthalmol Vis Sci 2000;41:267-273.
66. Shimada Y, Horiguchi M. Stray lightinduced multifocal electroretinograms. Invest Ophthalmol Vis Sci 2003;44:1245-1251.
67. Palmowski A, Allgayer R, Heinemann-Vernaleken B, Ruprecht K. Influence of photodynamic therapy in choroidal neovascularization on focal retinal function assessed with the multifocal electroretinogram and perimetry. Ophthalmology 2002;109:1788-1792.
68. Lai T, Chan W-M, Lam D. Transient reduction in retinal function revealed by multifocal electroretinogram after photodynamic therapy. Am J Ophthalmol 2004;137:826-833.
69. Moschos M, Panayotidis D, Theodossiadis G, Moschos M. Assessment of macular function by multifocal electroretinography in age-related macular degeneration before and after photodynamic therapy. J Fr Ophthalmol 2004;27:1001-1006.
70. Jiang L, Jin C, Huang S, Wu D, Wu L. The changes of multifocal electroretinography in the early stage of photodynamic therapy for choroidal neovascularisation. Doc Ophthalmol 2003;107:165-170.
71. Rü;ther K, Breidenback K, Schwartz R, Hassenstein A, Richard G. Testing central retinal function with multifocal electroretinography before and after photodynamic therapy. [in German] Ophthalmologe 2003;100:459-464.
72. Feigl B, Brown B, Lovie-Kitchin J. Cone-and rod-mediated retinal function before and after multiple laser therapies in age-related macular degeneration. Invest Ophthalmol Vis Sci 2004: Abstract 799.
73. Abri A, Binder S, Harrer E. Multifocal ERG (mfERG) examination in the follow-up of AMD patients with subretinal surgery and autologous RPE-cell transplantation. [in German] Spektrum der Augenheilkunde 1998;213:174-181.
74. Binder S, Krebs I, Hilgers R, Abri A, Stolba U, Assadoulina A, Kellner L, Stanzel B, Jahn C, Feichtinger H. Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: a prospective trial. Invest Ophthalmol Vis Sci 2004;45:4151-4160.
75. Binder S, Stolba U, Krebs I, Kellner L, Jahn C, Feichtinger H, Povelka M, Frohner U, Kruger A, Hilgers R-D, Krugluger W. Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularisation resulting from age-related macular degeneration: a pilot study. Am J Ophthalmol 2002;133:215-225.
76. Radtke N, Aramant R, Seiler M, Petry H. Preliminary report: indications of improved visual function after retinal sheet transplantation in retinitis pigmentosa patients. Am J Ophthalmol 1999;128:384-387.
77. Verteporfin In Photodynamic Therapy (VIP) Study Group. Verteporfin therapy of subfoveal choroidal neovascularisation in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularisation-verteporfin in photodynamic therapy report 2. Am J Ophthalmol 2001;131:541-560.
78. Jackson GR, Owsley C, Curcio CA. Photoreceptor degeneration and dysfunction in aging and age-related maculopathy. Ageing Res Rev 2002;1:381-396.
79. Curcio C, Owsley C, Jackson G. Spare the rods, save the cones in aging and agerelated maculopathy. Invest Ophthalmol Vis Sci 2000;41:2015-2018.
80. Mohand-Said S, Hicks D, Leveillard T, Picaud S, Porto F, Sahel J. Rod-cone interactions: developmental and clinical significance. Prog Retin Eye Res 2001;20:451-467.
81. Hicks D, Sahel JA. The implications of roddependent cone survival for basic and clinical research. Invest Ophthalmol Vis Sci 1999;40:3071-3074.
82. Mohand-Said S, Hicks D, Simonutti M, Tran-Minh D, Deudon-Combe A, Dreyfus H, Silverman M, Ogilvie J, Tenkova T, Sahel J. Photoreceptor transplants increase host cone survival in the retinal degeneration (rd) mouse. Ophthalmic Res 1997;29:290-297.
83. Hood D, Wladis E, Shady S, Holopigian K, Li J, Seiple W. Multifocal rod electroretinograms. Invest Ophthalmol Vis Sci 1998;39:1152-1161.
84. Bearse MJ, Han Y, Schneck M, Adams A. Retinal function in normal and diabetic eyes mapped with slow flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 2004;45:296-304.
85. Greenstein V, Holopigian K, Hood D, Seiple W, Carr R. The nature and extent of retinal dysfunction associated with diabetic macular edema. Invest Ophthalmol Vis Sci 2000;41:3643-3654. (Pubitemid 30774958)
86. Shimada Y, Li Y, Bearse M, Sutter E, Fung W. Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol 2001;85:414-419.
87. Shimada Y, Bearse MJ, Sutter E. Multifocal electroretinograms combined with periodic flashes: direct responses and induced components. Graefe's Arch Clin Exp Ophthalmol 2005;243:132-141.
88. Brown B, Tobin C, Roche N, Wolanowski A. Cone adaptation in age-related maculopathy. Am J Optom Physiol Opt 1986;63:450-454.