Retinal sensitivity to flicker modulation: Reduced by early age-related maculopathy

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 6, 2000, Pages 1498-1506

  Falsini, Benedetto ^a   Fadda, Antonello ^b   Iarossi, Giancarlo ^a   Piccardi, Marco ^a   Canu, Doriana ^a   Minnella, Angelo ^a   Serrao, Sebastiano ^a   Scullica, Luigi ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EYE FUNDUS; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; MALE; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA DEGENERATION; VISUAL ACUITY;

AGED; AGED, 80 AND OVER; COLOR VISION DEFECTS; CONES (RETINA); ELECTRORETINOGRAPHY; FEMALE; FLICKER FUSION; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; VISUAL ACUITY;

EID: 0034014894     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. The International ARM Epidemiological Study Group. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol 1995; 39:367-374.
2. Curcio CA, Medeiros NE, Leigh Millican C. Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1996;37:1236-1249.
3. Curcio CA, Medeiros NE, Leigh Millican C. The Alabama age-related macular degeneration grading system for donor eyes. Invest Ophthalmol Vis Sci. 1998;39:1085-1096.
4. Jackson JR, Owsley C. Cordle EP, Finley CD. Aging and scotopic sensitivity. Vision Res. 1998;38:3655-3662.
5. Mayer MJ, Spiegler SJ, Ward B, Glucs A, Kim CBY. Mid frequency loss of foveal flicker sensitivity in early stages of age-related maculopathy. Invest Ophthalmol Vis Sci. 1992a;1992a:33:3136-3142.
6. Eisner A, Stoumbos VD, Klein ML, Fleming SA. Relations between fundus appearance and function. Eyes whose fellow eye has exudative age-related macular degeneration. Invest Ophthalmol Vis Sci. 1991;32:8-20.
7. Tolentino MJ, Miller S, Gaudio AR, Sandberg MA. Visual field deficits in early age-related macular degeneration. Vision Res. 1994,34:409-413.
8. Mayer MJ, Ward B, Klein R, Talcott JB, Dougherty RF, Glues A. Flicker sensitivity and fundus appearance in pre-exudative age-related maculopathy. Invest Ophthalmol Vis Sci. 1994;35:1138-1149.
9. Midena E, Degli Angeli C. Blarzino MC, Valenti M, Segato T. Macular function impairment in eyes with early age-related macular degeneration. Invest Ophthalmol Vis Sci. 1997;38:469-477.
10. de Lange H. Research into the dynamic nature of the human fovea-cortex systems with intermittent and modulated light, I: attenuation characteristics with white and colored light. J Opt Soc Am. 1958;48:777-784.
11. Mayer MJ, Spiegler SJ, Ward B, Glucs A, Kim CBY. Foveal flicker sensitivity discriminates ARM-risk from healthy eyes. Invest Ophthalmol Vis Sci. 1992h;33:3143-3149.
12. Mayer MJ. Spiegler SJ. Ward B, Glues A, Kim CBY. Preliminary evaluation of flicker sensitivity as a predictive test for exudative age-related maculopathy. Invest Ophthalmol Vis Sci. 1992c;33: 3150-3155.
13. Seiple WH, Siegel IM, Carr RE, Mayron C. Objective assessment of temporal modulation transfer functions using the focal ERG. Am J Optom Physiol Opt. 1986a;63:1-6.
14. Seiple WH, Holopigian K, Greenstein VC, Hood DC. Sites of cone system sensitivity loss in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1993;34:2638-2645.
15. Seiple WH, Holopigian K. Outer-retina locus of increased flicker sensitivity of the peripheral retina. J Opt Soc Am. 1996;13:658-668.
16. Bush RA, Sieving PA. Inner retinal contribution to the primate photopic fast flicker electroretinogram. J Opt Soc Am. 1996;13: 557-565.
17. Seiple WH, Holopigian K, Greenstein V, Hood DC. Temporal frequency dependent adaptation at the level of the outer retina in humans. Vision Res. 1992;32:2043-2048.
18. Nelson JI, Seiple WH, Kuperemith MJ, Carr RE. Lock-in techniques for the swept stimulus evoked potential. J Clin Neurophysiol. 1984;1:409-415.
19. Seiple WH, Siegel WM, Carr RE, Mayron C. Evaluating macular function using the focal ERG. Invest Ophthalmol Vis Sci. 1986b; 27:1123-1130.
20. Wu S, Burns SA, Elsner AE. Effects of flicker adaptation and temporal gain control on the flicker ERG. Vision Res. 1995;35:2943-2953.
21. Baron WS, Boynton RM. Response of primate cones to sinusoidally flickering homochromatic stimuli. J Physiol. 1975;246:311-331.
22. Wu S, Burns SA. Analysis of retinal light adaptation with the flicker electroretinogram. J Opt Soc Am. 1996;13:649-657.
23. Falsini B, Porrello G, larossi G, Fadda A, Piccardi M, Scullica L. Macular flicker ERGs as a function of stimulus modulation: early changes in age-related maculopathy [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1998;39(4):S384. Abstract nr 1786.
24. Klein R, Davis MD, Magli IL, Segal P, Klein BEK, Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991;98:1128-1134.
25. Schatz H. Fluorescein angiography. In. Ryan SJ, Schachat AP, Murphy RB, Patz A, eds. Retina. St Louis: Mosby; 1989:3-77.
26. Seiple WH, Greenstein V, Carr R. Losses of temporal modulation sensitivity in retinal degenerations. Br J Ophthalmol. 1989;73: 440-447.
27. Fadda A, Falsini B. Precision LED-based stimulator for focal electroretinography. Med Biol Eng Comp. 1997;35:441-444.
28. Fiorentini A, Maffei L, Pirchio M, Spinelli D, Porciatti V. The ERG in response to alternating gratings in patients with diseases of the peripheral visual pathway. Invest Ophthalmol Vis Sci. 1981;21: 490-493.
29. Porciatti V. Non-linearities in the focal ERG evoked by pattern and uniform-field stimulation. Invest Ophthalmol Vis Sci. 1987;28: 1306-1313.
30. Hawlina M, Konec B. New non-corneal HK-loop electrode for clinical electroretinography. Doc Ophthalmol. 1992;81:253-259.
31. Porciatti V, Falsini B. Inner retina contribution to the flicker electroretinogram: a comparison with the pattern electroretinogram. Clin Vis Sci. 1993;8:435-447.
32. Porciatti V, Burr D C, Morrone C, Fiorentini A The effects of ageing on the pattern electroretinogram and visual evoked potential in humans. Vision Res. 1992;32:1199-1209.
33. Weiner A, Sandberg MA. Normal change in the foveal cone ERG with increasing duration of light exposure. Invest Ophthalmol Vis Sci. 1991;32:2842-2845.
34. Valeton JM, Van Norren D Light adaptation of primate cones: an analysis based on extracellular data. Vision Res. 1983;23:1539-1547.
35. Hood DC, Birch D. Changes in the gain and time constant of human cone photoreceptors with light adaptation: Advances in Color Vision. Tech Digest Opt Soc Am. 1992;4:10-12.
36. Dagnelie G, Massof RW. Foveal cone involvement in retinitis pigmentosa progression assessed through psychophysical impulse response parameters. Invest Ophthalmol Vis Sci. 1993;34:231-242.
37. Sandberg MA, Miller S, Gaudio AR. Foveal cone ERGs in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 1993;34:3477-80.
38. Remulla JFC, Gaudio AR, Miller S, Sandberg MA. Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Br J Ophthalmol. 1995;79:558-561.