Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress

Free Radical Biology and Medicine

Volumn 40, Issue 5, 2006, Pages 808-816

  Minamiyama, Yukiko ^a,b   Takemura, Shigekazu ^b   Hai, Seikan ^b   Suehiro, Shigefumi ^b   Okada, Shigeru ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome P450; Free radical; Nitric oxide cyclic GMP pathway; Nitroglycerin; Tolerance; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CYCLIC GMP; CYTOCHROME P450; FREE RADICAL; GLYCERYL TRINITRATE; NITRATE; PROTEIN KINASE; SERINE; SUPEROXIDE; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ALPHA TOCOPHEROL DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG TOLERANCE; IMMUNOBLOTTING; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALPHA-TOCOPHEROL; ANIMALS; AORTA; CELL ADHESION MOLECULES; CYCLIC GMP; CYTOCHROME P-450 CYP1A2; DOWN-REGULATION; DRUG TOLERANCE; LIPID PEROXIDATION; MALE; MICROFILAMENT PROTEINS; MYOCARDIUM; NITRATES; NITRIC OXIDE; NITROGLYCERIN; OXIDATIVE STRESS; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES; SERINE; VASODILATOR AGENTS; VITAMIN E; VITAMIN E DEFICIENCY;

ANIMALIA;

EID: 33644648650     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.10.038     Document Type: Article

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